Inhibitory Effect of Preirradiation Saccharin Habituation on Conditioned Avoidance Behavior

McLaurin, William A.; Farley, John A.; Scarborough, Barron B.

doi:10.2307/3571391

Cited by 49 publications

(17 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could become an accelerating cycle leading to structural changes. They suggested that this type of plasticity might have a half‐life of 3–6 days, which fits well with our data and other data of the duration of latent inhibition (McLaurin et al ., 1963; Lubow, 1989).…”

Section: Discussionsupporting

confidence: 92%

“…This could become an accelerating cycle leading to structural changes. They suggested that this type of plasticity might have a half-life of 3-6 days, which fits well with our data and other data of the duration of latent inhibition (McLaurin et al, 1963;Lubow, 1989). Kennedy (2000) proposed a model in which activation of the NMDA receptor leads to CaMKII inhibition of the synaptic ras GTPase-activating protein SynGAP.…”

Section: Discussionsupporting

confidence: 92%

“…Latent inhibition is a long‐lasting phenomenon by which pre‐exposure to a to‐be‐conditioned stimulus (CS) without consequence results in decreased responding to the CS after subsequent pairings with an unconditioned stimulus (US) (McLaurin et al ., 1963; Weiner et al , 1988; Lubow, 1989; Weiner, 2003). The pharmacology of latent inhibition has been well studied (for review see Weiner, 2003), but less is known about the underlying molecular substrates.…”

Section: Introductionmentioning

confidence: 99%

“…Protein synthesis supports the development of long‐term memories (Davis & Squire, 1984; Tully et al ., 1994; Maren et al ., 2003). Because latent inhibition is long lasting (McLaurin et al ., 1963), we hypothesized that latent inhibition of cued fear conditioning would be disrupted by the protein synthesis inhibitor anisomycin. Anisomycin directly infused into the gustatory cortex disrupted latent inhibition of conditioned taste aversion (Rosenblum et al ., 1993).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Latent inhibition of cued fear conditioning: an NMDA receptor‐dependent process that can be established in the presence of anisomycin

Lewis

Gould

2004

Eur J of Neuroscience

View full text Add to dashboard Cite

Much of the research examining the biological basis for long-term memories has focused on mechanisms that support the formation of conditioned associations. Less information is available on biological mechanisms which underlie processes that modify the strength of conditioned associations. Latent inhibition is a phenomenon by which pre-exposure to a to-be-conditioned stimulus (CS) weakens subsequent conditioning of that CS to an unconditioned stimulus (US). Here we report that latent inhibition of cued fear conditioning is dependent on NMDA receptor activation. MK-801 (1 mg/kg), an NMDA receptor antagonist, abolished latent inhibition of cued fear conditioning. This dose of MK-801 administered before training did not disrupt cued fear conditioning. Conversely, anisomycin (150 mg/kg), a protein synthesis inhibitor, had no effect on latent inhibition of cued fear conditioning when administered 20 min before, immediately after, or 2, 4, 6, or 8 h after CS pre-exposure. Furthermore, continuous anisomycin administration (50 mg/kg, administered every 2 h for 6 h starting 20 min prior to pre-exposure) did not disrupt latent inhibition of cued fear conditioning. In addition, anisomycin had no effect on a long-lasting version of latent inhibition of cued fear conditioning that was maintained over a 7-day interval. Anisomycin administered before training, however, disrupted learning of the CS-US association. These findings suggest that latent inhibition of cued fear conditioning is a long-lasting NMDA receptor-dependent process that can develop during the inhibition of protein synthesis.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Latent inhibition of cued fear conditioning: an NMDA receptor‐dependent process that can be established in the presence of anisomycin

Lewis

Gould

2004

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…The novelty of a stimulus has been shown to be an important factor in the establishment of a conditioned taste aversion. Exposure to a taste prior to its pairing with illness retards the development of the aversion (Elkins, 1973;Fenwick, Mikulka, & Klein, 1975;McLaurin, Farley, & Scarborough, 1963;. Also, rats will rapidly develop an aversion to a novel taste even when both the novel and familiar tastes are paired with illness (Kalat, 1974;Kalat & Rozin, 1973;Revusky & Bedarf, 1967).…”

mentioning

confidence: 99%

Postconditioning CS-alone exposure as a source of interference in a taste aversion paradigm

et al. 1978

View full text Add to dashboard Cite

Reduction of learned taste aversions by pre-exposure to drugs

Vogel¹,

Nathan²

1976

Psychopharmacology

View full text Add to dashboard Cite

Taste aversions are induced by a variety of psychotropic drugs. In the present experiments taste aversions induced by the barbiturate hypnotic drug, amobarbital, were dramatically reduced by prior exposure to the drug. Increasing numbers of pre-exposures were associated with larger reductions in taste aversions. Reductions in sleeping time (a widely accepted measure of tolerance to barbiturate drugs) were not correlated with reductions in taste aversions. Taste aversions induced by amobarbital were also impaired following pre-exposure to the pharmacologically dissimilar drug d-amphetamine. These results suggest that reduced taste aversions following pre-exposure to drugs may reflect habituation to drug-related stimuli and not solely the development of tolerance to those drugs.

show abstract

Inhibitory Effect of Preirradiation Saccharin Habituation on Conditioned Avoidance Behavior

Cited by 49 publications

References 5 publications

Latent inhibition of cued fear conditioning: an NMDA receptor‐dependent process that can be established in the presence of anisomycin

Latent inhibition of cued fear conditioning: an NMDA receptor‐dependent process that can be established in the presence of anisomycin

Postconditioning CS-alone exposure as a source of interference in a taste aversion paradigm

Reduction of learned taste aversions by pre-exposure to drugs

Contact Info

Product

Resources

About