Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling

Shah, Bukhtiar H.; Nawaz, Zafar; Pertani, Shamim; Roomi, Asad; Mahmood, Hammad; Saeed, Sheikh A.; Gilani, Anwarul Hassan

doi:10.1016/s0006-2952(99)00206-3

Cited by 200 publications

(131 citation statements)

References 30 publications

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“…᭺ϭcompound 2; ϭcompound 7; ᭹ϭcompound 11; ᭝ϭcompound 12; and ᮀϭcurcumin. 30 was used as a parameter instead of IC 50 value since the 50% inhibitory effect was not reached until the highest experimental concentration. C48/80ϭcompound 48/80 10 mg/ml; thapsigargin 0.5 mM; ionomycin 1 mM; PMA-IONOϭphorbol myristate acetate 10 nM-ionomycin 0.1 mM.…”

Section: Discussionmentioning

confidence: 99%

Effects of Benzylidenecyclopentanone Analogues of Curcumin on Histamine Release from Mast Cells

2009

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Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is a natural yellow pigment isolated from the rhizomes of the plant Curcuma longa L. (turmeric). Its chemical structure is described in Fig. 1.1) The pharmacological effects of curcumin include anti-inflammatory, 2) antioxidant, 3) antiprotozoal, 4) antibacterial, 5) anticancer, 6) antihepatotoxic, 7) hypolipidemic, 8) and antifibrotic effects. 9) Curcumin showed no toxicity in acute toxicity studies in rats, guinea pigs, and monkeys, 10) as well as in humans. 11)Several prior studies have examined the effects of curcumin on allergic diseases. An ethyl acetate extract of Curcuma longa L., which contains curcuminnoids, exhibited a preventive effect in allergic type I and IV models.12) Furthermore, both the ethyl acetate extract of Curcuma longa L. and curcumin were found to decrease histamine release from mast cells. However the ethyl acetate extract of Curcuma longa L. had somewhat stronger activity than that of curcumin, which may have been due to the presence of curcumin derivatives.13) Several studies have also examined the anti-allergic activity of curcumin and curcumin-related compounds in relation to their antioxidant effects. Most of these compounds were shown to inhibit histamine release from rat basophilic leukemia (RBL-2H3) cells; however, histamine release was decreased by antioxidant compounds and by those that lacked antioxidant activity. The results suggested that the hydroxy moiety of curcumin is responsible for antioxidant activity and may also contribute to the inhibition of histamine release. 14) In a guinea pig model of airway hyperresponsiveness, curcumin at a dose of 20 mg/kg body weight significantly inhibited ovalbumin (OVA)-induced airway constriction and airway hyperactivity. 15)Although curcumin has a wide range of potentially beneficial pharmacological effects, its use is limited by the compounds instability. The stability of curcumin is strongly affected by factors such as pH and exposure to light.16) The kinetics of the pH-dependent degradation of curcumin in aqueous medium at various pH levels was studied by Tonnesen and Karlsen. 17) They found that curcumin in aqueous solution at pH less than 7 is quite stable, but with increasing pH, curcumin decomposes. The main decomposition products are ferulic acid and feruloylmethane, which rapidly undergo retro-aldol condensation to vanillin and acetone. The instability of curcumin at alkaline pH is caused by the active methylene moiety. Decomposition of curcumin can also occur as a result of light exposure, and this process is also mediated by the active methylene moiety; the degradation products include ferulic aldehyde, ferulic acid, dihydroxynaphthalene product, 4-vinylguaiacol, vanillin, and vanillic acid. 16,17) The modification of the middle site of curcumin to compounds such as the 1,4-pentadiene-3-ones, cyclopentanone, and cyclohexanone which lack the active methylene moiety and one carbonyl moiety of curcumin may show improved stability. These compounds which st...

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Section: Discussionmentioning

confidence: 99%

Effects of Benzylidenecyclopentanone Analogues of Curcumin on Histamine Release from Mast Cells

2009

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“…The cause of these actions may involve the inhibition of TX synthase. By contrast, the essential oil of turmeric does not exhibit any evident anti-platelet activity (41). In addition, Liu et al observed that the combination of curcumin and clopidogrel (antiplatelet family of thienopyridines) had no significant effect on the maximum platelet aggregation rate of rats compared with the use of clopidogrel alone (42).…”

Section: Antiplatelet Activitymentioning

confidence: 99%

Biological and therapeutic activities, and anticancer properties of curcumin

Perrone

Ardito

Giannatempo

et al. 2015

Experimental and Therapeutic Medicine

259

186

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Abstract. Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant. Curcumin has been used extensively in Ayurvedic medicine, as it is nontoxic and exhibits a variety of therapeutic properties, including antioxidant, analgesic, anti-inflammatory and antiseptic activities. Recently, certain studies have indicated that curcumin may exert anticancer effects in a variety of biological pathways involved in mutagenesis, apoptosis, tumorigenesis, cell cycle regulation and metastasis. The present study reviewed previous studies in the literature, which support the therapeutic activity of curcumin in cancer. In addition, the present study elucidated a number of the challenges concerning the use of curcumin as an adjuvant chemotherapeutic agent. All the studies reviewed herein suggest that curcumin is able to exert anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against cancers of the liver, skin, pancreas, prostate, ovary, lung and head neck, as well as having a positive effect in the treatment of arthritis.

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“…Curcumin has been demonstrated to exert an inhibitory effect on platelet aggregation that has been attributed to its inhibitory effect on thromboxane A 2 production (26,27). Vascular factors are posited to play a role in AD or in the manifestations of dementia and inhibitors of platelet aggregation may be of benefit.…”

Section: Hemostatic Propertiesmentioning

confidence: 99%

A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

Ringman¹,

Frautschy²,

Cole³

et al. 2005

CAR

444

281

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There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimer's disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small shortterm studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.

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Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling

Cited by 200 publications

References 30 publications

Effects of Benzylidenecyclopentanone Analogues of Curcumin on Histamine Release from Mast Cells

Effects of Benzylidenecyclopentanone Analogues of Curcumin on Histamine Release from Mast Cells

Biological and therapeutic activities, and anticancer properties of curcumin

A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

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