Effects of Benzylidenecyclopentanone Analogues of Curcumin on Histamine Release from Mast Cells

Nugroho, Agung Endro; Ikawati, Zullies; Maeyama, Kazutaka

doi:10.1248/bpb.32.842

Cited by 23 publications

(21 citation statements)

References 32 publications

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“…Compound 48/80 also stimulates histamine release from RPMCs in both the presence and absence of extracellular calcium. The present study demonstrates that curcumin potently suppressed histamine release probably through the inhibition of the degranulation process following a rise in intracellular Ca 2+ levels, in accordance with previous reports (Matsuda et al, 2004; Suzuki et al, 2005; Nugroho et al, 2009). …”

Section: Discussionsupporting

confidence: 93%

Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation

et al. 2010

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Mast cells participate in allergies and inflammation by secreting a variety of pro-inflammatory mediators. Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative, and anti-allergic properties. The effects of curcumin on compound 48/80-induced mast cell activation and passive cutaneous anaphylactoid reactions are unknown. In this report, we investigated the influences of curcumin on the passive cutaneous anaphylactoid response in vivo and compound 48/80-induced mast cell activation in vitro. The mechanism of action was examined by calcium uptake measurements and cAMP assays in mast cells. Curcumin significantly attenuated the mast cell-mediated passive cutaneous anaphylactoid reaction in an animal model. In agreement with this in vivo activity, curcumin suppressed compound 48/80-induced rat peritoneal mast cell (RPMC) degranulation and histamine release from RPMCs. Moreover, compound 48/80-elicited calcium uptake into RPMCs was reduced in a dose-dependent manner by curcumin. Furthermore, curcumin increased the level of intracellular cAMP and significantly inhibited the compound 48/80-induced reduction of cAMP in RPMCs. These results corroborate the finding that curcumin may have anti-allergic activity.

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Section: Discussionsupporting

confidence: 93%

Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation

et al. 2010

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“…When CUR was ingested after exercise, the increase in CK was significantly lower and CK reduced faster than PLA after 5 days of exercise (Figure B). It has been reported that CUR has a membrane protective effect and inhibits production of histamine and prostaglandin (PG), which are involved in vascular hyperpermeability . In addition, the structure of the membrane changes depending on the blood CUR concentration .…”

Section: Discussionmentioning

confidence: 99%

Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation

Tanabe

Chino

Ohnishi

et al. 2019

Scandinavian Med Sci Sports

131

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We examined the effect of curcumin (CUR) ingestion before or after exercise on changes in muscle damage and inflammatory responses after exercise. We conducted two parallel experiments with different CUR ingestion timings using a double‐blind crossover. In Exp. 1, ten healthy men ingested 180 mg d−1 of CUR or placebo (PLA) 7 days before exercise. In Exp. 2, ten other healthy men ingested 180 mg d−1 of CUR or PLA 7 days after exercise. They performed 30 maximal isokinetic (120°s−1) eccentric contractions of the elbow flexors using an isokinetic dynamometer, and this was repeated with the other arm ≥4 weeks later. Maximal voluntary contraction (MVC) torque of the elbow flexors, elbow joint range of motion (ROM), muscle soreness, and serum creatine kinase (CK) activity were measured before, immediately after, and 1‐7 days after exercise. Plasma interleukin‐8 (IL‐8) was measured before, immediately after, 12 hours after, and 1‐7 days after exercise. The changes were compared over time. In Exp. 1, no significant differences were found between CUR and PLA subjects for each parameter. However, increases in IL‐8 were significantly reduced 12 hours after exercise when CUR was ingested before exercise. In Exp. 2, compared to the PLA subjects, MVC torque and ROM were higher 3‐7 days and 2‐7 days after exercise (P < 0.05), respectively, whereas muscle soreness and CK activity were lower 3‐6 days and 5‐7 days after exercise (P < 0.05), respectively, in CUR subjects. CUR ingestion before exercise could attenuate acute inflammation, and after exercise could attenuate muscle damage and facilitate faster recovery.

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“…19) Curcumin were also found to decrease histamine release from mast cells. 20) Additionally, IL-10 gene therapy could ameliorate the acute phase of EAM by stabilizing mast cells. This therapeutic mechanism is exerted by the binding of IL-10 to specific IL-10 receptors located on mast cells, leading to prevention of the release of inflammatory mediators.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Ameliorates Cardiac Inflammation in Rats with Autoimmune Myocarditis

Mito

Watanabe

Harima

et al. 2011

Biological & Pharmaceutical Bulletin

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Curcumin is a natural polyphenolic compound abundant in the rhizome of the perennial herb turmeric, Curcuma longa. It is commonly used as a dietary spice and coloring agent in cooking, and is used anecdotally as an herb in traditional Indian and Chinese medicine. It has been reported that curcumin has the potential to protect against cardiac inflammation through suppression of GATA-4 and nuclear factor-κB (NF-κB); however, no study to date has addressed the effect of curcumin on experimental autoimmune myocarditis (EAM) in rats. In this study, 8-week-old male Lewis rats were immunized with cardiac myosin to induce EAM. They were then divided randomly into a treatment or vehicle group and orally administrated curcumin (50 mg/kg/d) or 1% gum arabic, respectively, for 3 weeks after myosin injection. We performed hemodynamic, echocardiographic, hematoxylin and eosin staining, mast cell staining and Western blotting studies to evaluate the protective effect of curcumin in the acute phase of EAM. Cardiac functional parameters measured by hemodynamic and echocardiographic studies were significantly improved by curcumin treatment. Furthermore, curcumin reduced the heart weight-to-body weight ratio, area of inflammatory lesions and the myocardial protein level of NF-κB, interleukin (IL)-1β, tumor necrosis factor (TNF)-α and GATA-4. Our results indicate that curcumin has the potential to protect against cardiac inflammation through suppression of IL-1β, TNF-α, GATA-4 and NF-κB expresses, and may provide a novel therapeutic strategy for autoimmune myocarditis.

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Effects of Benzylidenecyclopentanone Analogues of Curcumin on Histamine Release from Mast Cells

Cited by 23 publications

References 32 publications

Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation

Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation

Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation

Curcumin Ameliorates Cardiac Inflammation in Rats with Autoimmune Myocarditis

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