Inhibitory effect of banana (Musa sp. var. Nanjangud rasa bale) flower extract and its constituents Umbelliferone and Lupeol on α-glucosidase, aldose reductase and glycation at multiple stages

Ramu, Ramith; Shirahatti, Prithvi S.; Zameer, Farhan; Ranganatha, Lakshmi; Prasad, M. V. N. Ambika

doi:10.1016/j.sajb.2014.08.001

Cited by 91 publications

(88 citation statements)

References 39 publications

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“…Compounds 3, 4, 5, 8, 9, 10, 11 and 12 are known antioxidant agents (Van Kiem et al 2010;Moussouni et al 2011;Hugo et al 2012;Begum & Prasad 2012;Thangavel et al 2012;Santiago & Mayor 2014;Song & Park 2014;Hlila et al 2015) and may be responsible for the significant exhibited antioxidant capacity of the diethyl ether, ethyl acetate and n-butanol extracts of the plant. The compounds 3, 10 and 11 have already proved their antidiabetic potential by inhibiting the aldose reductase enzyme (Goodarzi et al 2006;Jung et al 2011;Ramu et al 2014) and may be responsible for the potent pharmacological activity and therapeutic role of T. humilis against the long-term diabetic complications and specifically the diethyl ether, ethyl acetate and n-butanol extracts of the plant. This is the first report of the isolation of two cycloexylethanoids from the genus Tephrosia.…”

Section: Structural Elucidation Of the Isolated Compoundsmentioning

confidence: 99%

Phytochemical analysis with the antioxidant and aldose reductase inhibitory capacities of Tephrosia humilis aerial parts’ extracts

Plioukas

Gabrieli

Lazari

et al. 2015

Natural Product Research

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The aerial parts of Tephrosia humilis were tested about their antioxidant potential, their ability to inhibit the aldose/aldehyde reductase enzymes and their phenolic content. The plant material was exhaustively extracted with petroleum ether, dichloromethane and methanol, consecutively. The concentrated methanol extract was re-extracted, successively, with diethyl ether, ethyl acetate and n-butanol. All extracts showed significant antioxidant capacity, but the most effective was the ethyl acetate extract. As about the aldose reductase inhibition, all fractions, except the aqueous, were strong inhibitors of the enzyme, with the n-butanolic and ethyl acetate fractions to inhibit the enzyme above 75%. These findings provide support to the ethnopharmacological usage of the plant as antioxidant and validate its potential to act against the long-term diabetic complications. The phytochemical analysis showed the presence of 1,4-dihydroxy-3,4-(epoxyethano)-5-cyclohexene(1), cleroindicin E(2), lupeol(3), methyl p-coumarate(4), methyl 4-hydroxybenzoate(5), prunin(6), 5,7,2',5'-tetrahydroxyflavanone 7-rutinoside(7), protocatechuic acid(8), luteolin 7-glucoside(9), apigenin(10), naringin(11), rhoifolin(12) and luteolin 7-glucuronate(13).

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Section: Structural Elucidation Of the Isolated Compoundsmentioning

confidence: 99%

Phytochemical analysis with the antioxidant and aldose reductase inhibitory capacities of Tephrosia humilis aerial parts’ extracts

Plioukas

Gabrieli

Lazari

et al. 2015

Natural Product Research

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“…Further, the inhibitory effects on glycation were evaluated using in vitro bovine serum albumin glycation and analysis of the early glycation product (fructosamine), intermediate products (protein carbonyls) and AGEs. Both compounds exhibited higher inhibitory potential across all levels, compared with the crude extract and the positive control aminoguanidine …”

Section: Resultsmentioning

confidence: 95%

“…also analysed isolated exposure to two constituents of Musa sp. flower: umbelliferone and lupeol, which have significant antihyperglycaemic activity in vitro . Sundaram et al .…”

Section: Resultsmentioning

confidence: 99%

“…evaluated compounds isolated from an extract of the banana flower. Umbelliferone and lupeol were considered to be antidiabetic compounds, justified by the regeneration of β‐cells, and hence, leading to an improvement in insulin secretion with subsequent glycaemic reduction . Syringin demonstrated effects on glucose homeostasis that may be due to its effects on glucose uptake and glycogen synthesis …”

Section: Resultsmentioning

confidence: 99%

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Antidiabetic potential of Musa spp. inflorescence: a systematic review

Vilhena

Fachi

Marson

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives Extracts of parts Musa spp. have been used for the treatment of various diseases in traditional medicine. Studies have shown that these extracts have hypoglycaemic properties. The aim of this work was to gather evidence on the antidiabetic effects of Musa spp. inflorescence. Methods A systematic review was conducted with searches in three electronic databases, along with manual searches. Studies evaluating the antidiabetic properties of extracts of flower or bract of the genus Musa (in vitro or in vivo) were included. Key findings Overall, 16 studies were found. The reported assays were of hypoglycaemic effects, oral glucose tolerance, inhibitory activities in carbohydrate metabolism and digestive enzymes, enhanced glucose uptake activity and popular use of the extract in patients with diabetes type 2. In vitro studies showed that use of the extract was associated with antidiabetic effects (e.g. increased glucose uptake and inhibition of carbohydrate digestion enzymes). In induced diabetic models, Musa spp. extracts showed dose‐dependent glycaemic level reductions compared with pharmacological drugs (P < 0.05). Summary In general, promising results regarding antidiabetic activity were found for inflorescence of Musa spp., suggesting that this plant could represent a natural alternative therapy for treating diabetes mellitus type 2.

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“…To design potent therapeutic agents derived from these plants, great effort has been devoted to an elucidation of the active principles of extracts obtained from their various parts. A number of lowmolecular-weight bioactive phytochemicals such as alkaloids, saponins, flavonoids, tannins, phlobatannins, phenolics, glycosides, terpenoids, and steroids have been identified (Ramu et al 2014). In the last (Famakin et al 2016) diabetes mellitus, a metabolic disease whose incidence has been growing significantly in the Western world.…”

mentioning

confidence: 99%

Antidiabetic Compounds in Stem Juice from Banana

Nguyen¹,

Zachariasova²,

Spurna³

et al. 2017

Czech J. Food Sci.

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Nguyen D., Nováková A., Spurná K., Hričko J., Phung H., Viktorová J., Stránská M., Hajšlová J., Ruml T. (2017): Antidiabetic compounds in stem juice from babana grown in natural and greenhouse. Czech J. Food Sci., 35: 407-413.The stem juices from Musa × paradisiaca L. banana plants cultivated in their original natural habitat in Vietnam and those cultivated in a greenhouse in the Czech Republic were investigated for the presence of phytochemicals with antidiabetic potency. Respective bioactivities of these phytochemicals were also determined. Sample screening using ultrahigh performance liquid chromatography coupled with tandem high-resolution mass spectrometry (UHPL-HRMS/MS) method showed some differences in the pattern of bioactive compounds, both in terms of their number and concentration. p-Hydroxybenzoic and gallic acids were the predominant analytes found in stem juice from plants grown in Vietnam, while ferulic acid was the major compound found in juice obtained from greenhouse bananas. Despite differences in the occurrence of potentially antidiabetic compounds, both extracts exhibited comparable inhibitory activity against α-glucosidase and α-amylase.

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Inhibitory effect of banana (Musa sp. var. Nanjangud rasa bale) flower extract and its constituents Umbelliferone and Lupeol on α-glucosidase, aldose reductase and glycation at multiple stages

Cited by 91 publications

References 39 publications

Phytochemical analysis with the antioxidant and aldose reductase inhibitory capacities of Tephrosia humilis aerial parts’ extracts

Phytochemical analysis with the antioxidant and aldose reductase inhibitory capacities of Tephrosia humilis aerial parts’ extracts

Antidiabetic potential of Musa spp. inflorescence: a systematic review

Antidiabetic Compounds in Stem Juice from Banana

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