Inhibitory Effect of a Novel Bisphosphonate, TRK‐530, on Dental Calculus Formation in Rats

Sikder, M.N. Haq; Itoh, Masatoshi; Iwatsuki, Naofumi; Satoh, Hisashi

doi:10.1902/jop.2004.75.4.537

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…As expected, TRK-530 inhibited dental calculus formation in a dosedependent fashion when it was given in drinking water ( Fig. 6) (16). However, subcutaneous injection of TRK-530, at a dose that was assumed to correspond to the maximum amount of this compound absorbed from the intestine when rats received 1.5 mM TRK-530 in drinking water, did not have any significant effect, suggesting that the anticalculogenic effect of this compound was topical rather than systemic.…”

Section: Inhibitory Effect On the Formation Of Dental Calculussupporting

confidence: 84%

Pharmacological Topics of Bone Metabolism: A Novel Bisphosphonate for the Treatment of Periodontitis

et al. 2008

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Abstract. It has been reported that the pharmacological characteristics of bisphosphonates vary depending on the side chain attached to the carbon atom of the P-C-P bond. TRK-530 is a novel synthetic bisphosphonate with an anti-oxidant methylthio-phenylthio side chain. This compound has been suggested to have both anti-inflammatory and anti-bone-resorbing effects. Such a compound could be effective for the treatment of diseases with excessive bone resorption accompanied by inflammation. We have been studying this compound as a potential therapeutic agent for periodontitis. To date, we have found that 1) TRK-530 inhibited osteoclastic bone resorption in animals and in bone organ culture, 2) both systemic and topical administration of TRK-530 prevented alveolar bone loss in animals with experimental periodontitis, 3) TRK-530 prevented prostaglandin E 2 synthesis by inhibiting the expression of cyclooxygenase (COX)-2 mRNA, and 4) TRK-530 inhibited the formation of dental calculus. The above results suggest that TRK-530 might be useful for the treatment of alveolar bone loss in periodontitis.

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Section: Inhibitory Effect On the Formation Of Dental Calculussupporting

confidence: 84%

Pharmacological Topics of Bone Metabolism: A Novel Bisphosphonate for the Treatment of Periodontitis

et al. 2008

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“…Moreover, it can impede the conversion of dicalcium phosphate dehydrate (DCPD) to hydroxyapatite and reduce pellicle formation. Bisphosphonates, which are stable synthetic analogs of pyrophosphate with resistance to hydrolysis, have also been used as anti-calculus agents (Shinoda et al, 2008;Sikder et al, 2004). When used as advanced mineralization inhibitors, polyphosphates (e.g., hexametaphosphate) can reduce calculus formation (Sikder et al, 2004).…”

Section: Strategies For Prevention Of Calculus Formationmentioning

confidence: 99%

“…Bisphosphonates, which are stable synthetic analogs of pyrophosphate with resistance to hydrolysis, have also been used as anti-calculus agents (Shinoda et al, 2008;Sikder et al, 2004). When used as advanced mineralization inhibitors, polyphosphates (e.g., hexametaphosphate) can reduce calculus formation (Sikder et al, 2004). Phytate, which has structural similarities to pyrophosphate, is capable of inhibiting the formation of brushite and hydroxyapatite crystals in vitro and in vivo.…”

Section: Strategies For Prevention Of Calculus Formationmentioning

confidence: 99%

Detection, removal and prevention of calculus: Literature Review

Kamath

Nayak

2014

The Saudi Dental Journal

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Dental plaque is considered to be a major etiological factor in the development of periodontal disease. Accordingly, the elimination of supra- and sub-gingival plaque and calculus is the cornerstone of periodontal therapy. Dental calculus is mineralized plaque; because it is porous, it can absorb various toxic products that can damage the periodontal tissues. Hence, calculus should be accurately detected and thoroughly removed for adequate periodontal therapy. Many techniques have been used to identify and remove calculus deposits present on the root surface. The purpose of this review was to compile the various methods and their advantages for the detection and removal of calculus.

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“…Herforth 40 tested the use of a sodium etidronate mouthrinse using the mylar foil model and found that solutions containing 1% and 0.1% EHDP reduced calculus formation by 56.2% and by 56.8%, respectively. Inhibitory effects of a novel bisphosphonate, TRK‐530 (disodium dihydrogen [4‐(methylthio)phenylthio] methanebisphosphonate), were studied on dental calculus formation in rats and it was found that TRK‐530 inhibited the formation of dental calculus in a dose‐dependent fashion via a local effect by inhibition of the precipitation of calcium‐phosphate from solution 41 …”

Section: Discussionmentioning

confidence: 99%

Study of Orthophosphate, Pyrophosphate, and Pyrophosphatase in Saliva With Reference to Calculus Formation and Inhibition

Pradeep

Agarwal

Raju

et al. 2011

Journal of Periodontology

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A holistic approach toward the control of periodontal disease should include antiplaque and anticalculus agents. The results are conclusive that the components orthophosphate, pyrophosphate, and pyrophosphatase present in saliva have a very significant role to play in formation and inhibition of calculus. This study reinforces the idea of using pyrophosphate and newer bisphosphonates as potential anticalculus agents.

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Inhibitory Effect of a Novel Bisphosphonate, TRK‐530, on Dental Calculus Formation in Rats

Abstract: TRK-530 inhibited the formation of dental calculus in a dose-dependent fashion via a local effect. Inhibition of the precipitation of calcium-phosphate from solution might be involved in the anticalculogenic mechanism of this drug.

Cited by 11 publications

References 30 publications

Pharmacological Topics of Bone Metabolism: A Novel Bisphosphonate for the Treatment of Periodontitis

Pharmacological Topics of Bone Metabolism: A Novel Bisphosphonate for the Treatment of Periodontitis

Detection, removal and prevention of calculus: Literature Review

Study of Orthophosphate, Pyrophosphate, and Pyrophosphatase in Saliva With Reference to Calculus Formation and Inhibition

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