Study of Orthophosphate, Pyrophosphate, and Pyrophosphatase in Saliva With Reference to Calculus Formation and Inhibition

Pradeep, A.R.; Agarwal, Esha; Raju, P Arjun; Rao, Mohana; Faizuddin, Mohamed

doi:10.1902/jop.2010.100355

Cited by 10 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The presence of calculus may limit the ability to perform optimal oral hygiene practices and hence may increase the rate of biofilm deposition. This, in turn, may reduce drainage from the crevicular area .…”

Section: Formation Rate Of Dental Calculusmentioning

confidence: 99%

Dental calculus: the calcified biofilm and its role in disease development

Akcalı¹,

Lang²

2017

Periodontology 2000

View full text Add to dashboard Cite

Dental calculus represents the first fossilized record of bacterial communities as a testimony of evolutionary biology. The development of dental calculus is a dynamic process that starts with a nonmineralized biofilm which eventually calcifies. Nonmineralized dental biofilm entraps particles from the oral cavity, including large amounts of oral bacteria, human proteins, viruses and food remnants, and preserves their DNA. The process of mineralization involves metabolic activities of the bacterial colonies and strengthens the attachment of nonmineralized biofilms to the tooth surface. From a clinical point of view, dental calculus always harbors a living, nonmineralized biofilm, jeopardizing the integrity of the dento-gingival or implanto-mucosal unit. This narrative review presents a brief historical overview of dental calculus formation and its clinical relevance in modern periodontal practice.

show abstract

Section: Formation Rate Of Dental Calculusmentioning

confidence: 99%

Dental calculus: the calcified biofilm and its role in disease development

Akcalı¹,

Lang²

2017

Periodontology 2000

View full text Add to dashboard Cite

show abstract

“…Orthophosphate can trigger an increase in mineralization through its interaction with calcium ions and leads to precipitation of insoluble calcium apatite crystals, leading to calculus formation. 25 However, in this study, it has not been proven whether the increase in GCF amount due to repeated panoramic radiographic X-ray radiation exposure 1 time, 2 times, and 3 times can trigger calculus formation induced by the alkaline phosphatase enzyme in GCF.…”

Section: Discussionmentioning

confidence: 76%

The Effects of Panoramic Radiography on Gingival Crevicular Fluid Volume in Gingivitis

Rahmiyati¹,

Aspriyanto²,

Oktiani³

2021

Dentino

View full text Add to dashboard Cite

Background: Gingival crevicular fluid (GCF) is a biological fluid derived from the gingival sulcus and can be elevated in the inflammatory state of periodontal tissue, such as gingivitis. In previous studies, the number of GCF could also increase after panoramic radiographic exposure. Increase in GCF due to panoramic radiography is a sign of cell damage. Objective: To analyze the effects of panoramic radiography on the volume of GCF in wistar rats with gingivitis. Method: This type of research was true experimental with post test only and control group design. The sampling technique used was simple random sampling. A total of 25 wistar rats were classified into two control groups without exposure (state without gingivitis and gingivitis) and three groups treatment of exposure (state of gingivitis with 1 time, 2 times, and 3 times the exposure). GCF sampling using filter paper was carried out 10 minutes after panoramic radiographic exposure. The filter paper was stained by 2% ninhydrin solution, after that the GCF volume was calculated. Results: There was a significant difference in the number of GCF (p<0.05) in the group without gingivitis and exposure compared to all other groups, the gingivitis group without exposure compared to the gingivitis group with 3 times exposure, and the gingivitis group with 1 time exposure compared to the gingivitis group 3 times with exposure. Conclusion: Panoramic radiography can cause an increase in the volume of GCF in wistar rats with gingivitis. Keywords: GCF, gingivitis, panoramic radiography

show abstract

“…BPs also show the ability to inhibit the calcification process [ 43 ]. This property has become the basis for the topical use of BPs as an additive in the composition of toothpastes, in order to reduce the ability to form tartar on the tooth surface [ 44 ]. Generally used BPs are detected in saliva [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

A Study of Oral Health Parameters and the Properties and Composition of Saliva in Oncological Patients with and without Medication-Related Osteonecrosis of the Jaw Who Take Bisphosphonates

2023

View full text Add to dashboard Cite

Background and Objectives: The aim of this study was to examine how the status of the oral cavity, composition and properties of saliva change in oncological patients with and without Medication-Related Osteonecrosis of the Jaw (MRONJ) undergoing bisphosphonate therapy. Materials and Methods: A retrospective case–control study of 49 oncological patients using bisphosphonates (BPs) was conducted. The study population was divided into two groups—Group I consisted of 29 patients with MRONJ and Group II of 20 patients without MRONJ. The control group consisted of 32 persons without oncological history and without antiresorptive therapy. Standard dental examination included the assessment of the number of teeth remaining, teeth with caries and fillings, Approximal Plaque Index (API) and Bleeding on Probing (BOP). In terms of MRONJ, localization and stage were assessed. Laboratory tests of saliva included determination of pH and concentrations of Ca and PO4 ions, total protein, lactoferrin, lysozyme, sIgA, IgA, cortisol, neopterin, activity of amylase at rest, and stimulated saliva. The buffering capacity and microbiological tests (Streptococcus mutans, Lactobacillus spp. load) of stimulated saliva were also determined. Results: There were no statistically significant differences between the selected oral parameters and saliva of Group I and Group II. Significant differences were found between Group I and the control group. BOP, lysozyme and cortisol concentration were higher, while the number of teeth with fillings, Ca and neopterin concentrations were lower in comparison to the control group. In Group I, a significantly higher percentage of patients with a high colony count (>105) of Streptococcus mutans and Lactobacillus spp. was also found. The significant differences between Group II and the control group concerned the concentrations of lysozyme, Ca ions, sIgA, neopterin and the colony count of Lactobacillus spp. In the Group I patients who received a significantly higher cumulative dose of BP compared to the Group II, a significant positive correlation was found between the received BP dose and the BOP. Most MRONJ foci were stage 2 and were mainly located in the mandible. Conclusions: Among oncological patients with and without MRONJ undergoing BP therapy compared to the control group, there are statistically significant differences in the dental, periodontal and microbiological status and in the composition of the saliva. Particularly noteworthy are the statistically significant differences in the decreased level of Ca ions, the increased level of cortisol and the elements of saliva related to the immune response (lysozyme, sIgA, neopterin). Additionally, a higher cumulative dose of BPs may affect the susceptibility to the development of osteonecrosis of the jaws. Patients undergoing antiresorptive therapy should receive multidisciplinary medical care, including dental care.

show abstract

Study of Orthophosphate, Pyrophosphate, and Pyrophosphatase in Saliva With Reference to Calculus Formation and Inhibition

Cited by 10 publications

References 36 publications

Dental calculus: the calcified biofilm and its role in disease development

Dental calculus: the calcified biofilm and its role in disease development

The Effects of Panoramic Radiography on Gingival Crevicular Fluid Volume in Gingivitis

A Study of Oral Health Parameters and the Properties and Composition of Saliva in Oncological Patients with and without Medication-Related Osteonecrosis of the Jaw Who Take Bisphosphonates

Contact Info

Product

Resources

About