Inhibitory Breakdown and Dementia of the Alzheimer Type: A General Phenomenon?

Amieva, Hélène; Lafont, Sylviane; Auriacombe, Sophie; Carret, Nicolas Le; Dartigues, Jean‐François; Orgogozo, Jean‐Marc; Fabrigoule, Colette

doi:10.1076/jcen.24.4.503.1034

Cited by 78 publications

(75 citation statements)

References 56 publications

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“…More recently, Charlot [20; see also 21] assessed inhibitory / interference resolution functioning in working memory using tasks exploring the access, deletion and restraint functions, and demonstrated that the effects of aging are weaker on the access function than on the other two suppression functions. With regard to AD, Amieva et al [3] investigated the effects of mild AD on four suppression tasks: the negative priming paradigm, the Stroop test, the go/no-go task and the stop-signal task. Impaired performance was observed on the negative priming and Stroop tasks, but not on the go/no-go task, and only limited impairment was observed on the stop-signal task, suggesting that motor response inhibition could be relatively spared in that group of patients.…”

Section: Introductionmentioning

confidence: 99%

Specificity of inhibitory deficits in normal aging and Alzheimer's disease

Collette

Schmidt

Scherrer

et al. 2009

Neurobiology of Aging

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Deficits of suppression abilities are frequently observed in normal aging and Alzheimer's disease.However, few studies have explored these deficits in the two populations simultaneously using a large battery of tasks. The aim of the present study was to explore if the pattern of performance presented by elderly subjects and AD patients is in agreement with theoretical frameworks [104; see also 81], distinguishing between the concepts of inhibition (a voluntary suppression of irrelevant information) and interference (an automatic suppression process occurring prior to conscious awareness). The results obtained demonstrated that (1) there is an alteration of the inhibitory process in normal elderly subjects; (2) inhibitory and interference resolution processes are quantitately less efficient in AD, since these patients present a correct performance only for information which leaves weak traces in memory.

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Section: Introductionmentioning

confidence: 99%

Specificity of inhibitory deficits in normal aging and Alzheimer's disease

Collette

Schmidt

Scherrer

et al. 2009

Neurobiology of Aging

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“…Los pacientes no muestran evidencia de priming negativo. Igualmente, Amieva et al (2002) tampoco encuentran evidencia de este efecto en el grupo de pacientes con EA utilizando como estímulos dibujos. Por el contrario, Langley, Overmier, Knopman y Prod'homme (1998) encontraron una ejecución similar en jóvenes, mayores y pacientes con EA utilizando como estímulos letras.…”

Section: Control Inhibitoriounclassified

“…Se ha propuesto que las diferencias metodológicas podrían explicar las discrepancias en los resultados. Mientras Sullivan et al (1995) y Amieva et al (2002) utilizan estímulos más complejos (palabras y dibujos vs. letras) que se presentan de forma informatizada durante intervalos de tiempo cortos, Langley et al (1998) muestran en tarjetas listas de letras hasta que el participante da sus respuestas. Posteriormente se han desarrollado tareas de priming negativo espacial, en la que los participantes deben identificar la localización espacial del target.…”

Section: Control Inhibitoriounclassified

“…Con esta tarea se obtienen resultados contradictorios. Mientras Amieva et al (2002) no encuentran evidencia de una inhibición deficiente de respuestas motoras preparadas, Collette, Van der Linden, Delrue y Salmon (2002) sí encuentran déficit en los pacientes con EA. Amieva et al (2004) explican estas discrepancias indicando que, en ambos estudios, hay un 50% de ensayos "go" y un 50% de ensayos "no go", y que esto produciría un refuerzo relativamente débil de la respuesta motora en los ensayos "go".…”

Section: Control Inhibitoriounclassified

“…Este paradigma proporciona una forma de valorar la habilidad de inhibir una respuesta dirigida por una clave externa. Amieva et al (2002) observaron que los pacientes con EA cometían más errores (dar una respuesta aunque el tono indique que no se dé respuesta) que los controles, lo que sugiere dificultades para inhibir un plan motor predominante.…”

Section: Control Inhibitoriounclassified

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Procesos de control ejecutivo en la enfermedad de Alzheimer.

García-Viedma

Fernández-Guinea²,

Montes³

2012

analesps

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Resumen: El control ejecutivo (CE) es un mecanismo complejo compuesto por distintos subprocesos y vinculado al funcionamiento del lóbulo frontal. En los últimos años se ha generado una gran cantidad de investigación sobre los déficit de control ejecutivo (CE) en pacientes con enfermedad de Alzheimer (EA). Este análisis resulta de gran interés porque, por una parte, estudios recientes han observado precisamente alteraciones en regiones frontales en estos pacientes, y por otra parte, porque sus manifestaciones clínicas y conductuales en el inicio de la enfermedad están relacionadas con la afectación del CE. En este artículo se revisa detalladamente la evidencia existente sobre la afectación de los subprocesos del CE al inicio de la EA, determinando si habría un deterioro generalizado o disociaciones entre los componentes, así como sus posibles implicaciones básicas y aplicadas. Palabras clave: Alzheimer; control ejecutivo; neuropsicología; red ejecutiva.Title: Executive control processes in Alzheimer's disease. Abstract: It has been recently proposed that executive control (EC) is composed by different subprocesses. In recent times, EC deficits in Alzheimer's disease patients (AD) have been widely investigated. This analysis is very interesting because, on the one hand, recent studies have observed frontal lobe alterations on these demented patients, and on the other hand, Alzheimer's disease clinical and behavioural manifestations could be explained by the involvement of EC. This paper discusses in detail the possible involvement of EC subprocesses at the beginning of AD, determining if there would be a widespread decline or dissociations between components and their basic and clinical implications. Keywords: Alzheimer; executive control; neuropsychology; executive network. IntroducciónEl control ejecutivo (CE) es un mecanismo complejo que implica varias operaciones relacionadas con el control y la regulación de la conducta. Este mecanismo depende de un sistema neuronal distribuido en el que destaca el papel del córtex prefrontal (CPF), el cual tiene importantes conexiones córtico-corticales (con córtex asociativo y paralímbico) y córtico-subcorticales (principalmente con los ganglios basales, el tálamo y el hipocampo) (Cummings, 1993; Faglioni, 1999;Fuster, 1997;Karatekin, Lazareff y Asarnow, 2000;Quintana y Fuster, 1999). De esta forma, el correcto funcionamiento del CE depende de regiones corticales, tanto anteriores como posteriores, y subcorticales.El CE ha sido explorado extensamente en diversas patologías, como por ejemplo en tumores cerebrales, traumatismos craneoencefálicos, enfermedades cerebrovasculares, la enfermedad de Parkinson, la esclerosis múltiple, etc. (Fontaine, Azouvi, Remy, Bussel, y Samson, 1999; Brown y Marsden, 1998; Foong, Rozewicz, Quaghebeur, Davie y Kartsounis, 1997; Leskela, Heitanen, Kalska, Ylikoski y Pdijasvaara, 1999). Del mismo modo, el análisis del funcionamiento ejecutivo en la enfermedad de Alzheimer (EA) ha sido objeto de un gran interés. Diversos estudios muestran que esto...

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Late‐delayed cerebral involvement in systemic non‐Hodgkin lymphoma

Lossos

Ashhab

Sverdlin

et al. 2004

Cancer

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BACKGROUNDCentral nervous system involvement is a well recognized complication of systemic non‐Hodgkin lymphoma. Most central nervous system recurrences occur within the first 2 years after the initial diagnosis and are considered to represent clonally related recurrence of systemic disease. The authors attempted to investigate the clonal relation between the late‐delayed central nervous system involvement and the original systemic tumor.METHODSThe authors studied archival, formalin fixed, paraffin embedded tissue samples from 8 patients with isolated cerebral involvement diagnosed > 3 years after their initial presentation with aggressive, systemic, B‐cell non‐Hodgkin lymphoma. The rearranged immunoglobulin heavy‐chain variable region genes (VH) from both sites were amplified by polymerase chain reaction and were sequenced when necessary.RESULTSIn three of five patients who had interpretable results, a distinct, monoclonal, VH family‐specific band profile was obtained from the cerebral and systemic lymphoma. In the other two patients, a similar VH band pattern was observed and also was compared using direct sequencing, which demonstrated sequence differences between tumors from the two sites.CONCLUSIONSClonal variance between the cerebral and systemic lymphoma in these patients suggested the possibility that some instances of late‐delayed recurrence in the central nervous system represent a second, new B‐cell lymphoma rather than a true recurrence of the original systemic tumor, a finding that may have significant clinical and biologic implications. Cancer 2004. © 2004 American Cancer Society.

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Inhibitory Breakdown and Dementia of the Alzheimer Type: A General Phenomenon?

Cited by 78 publications

References 56 publications

Specificity of inhibitory deficits in normal aging and Alzheimer's disease

Specificity of inhibitory deficits in normal aging and Alzheimer's disease

Procesos de control ejecutivo en la enfermedad de Alzheimer.

Late‐delayed cerebral involvement in systemic non‐Hodgkin lymphoma

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