Inhibitory activities of some traditional Chinese herbs against testosterone 5α-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice

Zhang, Bei; Zhang, Rong-weng; Yin, Xiquan; Lao, Zizhao; Zhang, Zhe; Wu, Qingguang; Yu, Liang; Lai, Xiaoping; Yu-hua, Wan; Geng, Lanlan

doi:10.1016/j.jep.2015.11.012

Cited by 32 publications

(29 citation statements)

References 21 publications

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“…In the past several years, there have been numerous attempts to develop new agents capable of preventing and/or treating androgenic alopecia [2]. For example, natural extracts from several plants have been used for hair growth promotion via inhibiting 5α-reductase activity, including Phyllanthus niruri, Cacumen platycladi, Red ginseng, and Adiantum capillus-veneris [13][14][15][16].…”

Section: Resultsmentioning

confidence: 99%

Hair Growth-promoting Effect of Resina Pini and Its Main Constituent, Abietic Acid, in Mouse Model of Alopecia

Park¹,

Kim²

2016

Journal of the Society of Cosmetic Scientists of Korea

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Recently, increased attention has been directed toward medicinal extracts and their active ingredients as potential new drug candidates for androgenic alopecia. Resina Pini (RP), a resinous exudation obtained from Pinus sp. (Pinaceae), has been used as a traditional medicine for the treatment of infection, pain related to dental caries, and periodontal disease. Previously, we suggested that RP and its main constituent, abietic acid (abieta-7,13-dien-18-oic acid; AA), may play important roles against androgenic alopecia as 5α-reductase inhibitors. However, to date, there is no evidence that AA has hair growth-promoting effects in vivo. In this study, we found that 10 ∼ 300 mg/kg RP and 3 ∼ 30 mg/kg AA significantly promoted hair growth in a C3H/HeN mouse model of alopecia. To our knowledge, this is the first report of the hair growth-promoting effects of RP and AA in vivo. From these results, RP and its main constituent AA can promote hair growth in mouse by inhibiting 5α-reductase activity and may be effective alternative therapies for androgenic alopecia.

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Section: Resultsmentioning

confidence: 99%

Hair Growth-promoting Effect of Resina Pini and Its Main Constituent, Abietic Acid, in Mouse Model of Alopecia

Park¹,

Kim²

2016

Journal of the Society of Cosmetic Scientists of Korea

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“…P. emblica L. and Zingiber officinale promote hair growth by inhibiting 5 α -reductase activity [19] in vitro and in vivo. Moreover, Puerariae flos inhibits testosterone 5 α -reductase in vitro and exhibits antiandrogenic activity that was detected using a hair-growth assay in testosterone-sensitive male C57Black/6NCrSlc mice [40]. 5 α -Reductase catalyzes the conversion of testosterone into dihydrotestosterone (DHT) that combines with the same androgenic receptor to form a conjugate, which leads to hair-follicle miniaturization and then to telogen [41].…”

Section: Discussionmentioning

confidence: 99%

Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA‐5512 Effectively Stimulates Hair Growth and Promotes Hair Health

Gupta

Park

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The proprietary DA-5512 formulation comprises six herbal extracts from traditional oriental plants historically associated with therapeutic and other applications related to hair. Here, we investigated the effects of DA-5512 on the proliferation of human dermal papilla cells (hDPCs) in vitro and on hair growth in C57BL/6 mice and conducted a clinical study to evaluate the efficacy and safety of DA-5512. DA-5512 significantly enhanced the viability of hDPCs in a dose-dependent manner (p < 0.05), and 100 ppm of DA-5512 and 1 μM minoxidil (MXD) significantly increased the number of Ki-67-positive cells, compared with the control group (p < 0.05). MXD (3%) and DA-5512 (1%, 5%) significantly stimulated hair growth and increased the number and length of hair follicles (HFs) versus the controls (each p < 0.05). The groups treated with DA-5512 exhibited hair growth comparable to that induced by MXD. In clinical study, we detected a statistically significant increase in the efficacy of DA-5512 after 16 weeks compared with the groups treated with placebo or 3% MXD (p < 0.05). In conclusion, DA-5512 might promote hair growth and enhance hair health and can therefore be considered an effective option for treating hair loss.

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“…CSR significantly improved learning in D-galactose-and scopolamine-induced aging in mice and enhanced memory and memory retention ability by increasing the number of neurons in hippocampus CA1 area, by eliminating free radicals ability, and by reducing the extent of lipid peroxidation-induced damage in brain tissue [88]. CSR shows a strong 5α-reductase (5αR) inhibitory activity, considerably shortens the time of dorsal skin darkening and hair growth, and displays high hair re-growth promoting activity [89]. In addition, CSR inhibits blood-cell aggregation and enhances myocardial function [72,90].…”

Section: Effects On Nervous Systemmentioning

confidence: 99%

A Phytochemical and Pharmacological Review on Cynomorium songaricum as Functional and Medicinal Food

Cui

Gong

Xue

et al. 2018

Natural Product Communications

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Cynomorium songaricum Rupr. (CSR) has a long history of being widely used as a functional food and medicine by different ethnic groups worldwide; CSR is used to treat impotence and premature ejaculation and traditionally used as natural source of tonic food. Numerous bioactive compounds linked with human health were recently identified. In this work, all available information on CSR were retrieved from NCBI PubMed and CNKI database, and the recent findings about the compositions and functions of CSR were summarized. At least 76 bioactive compounds, including flavonoids, terpenoids, steroids, organic acids, saccharides, glycosides, and phloroglucinol adducts, were isolated and identified in CSR. These compounds render CSR with pharmacological functions, such as anti-aging, anti-oxidation, anti-fatigue, and anti-HIV activities, and the effects of CSR on immune system, nervous system, reproductive system, and other bioactivities were well reviewed; results serve as valuable data for further research and for development of human health-related products. However, studies on CSR were far from perfect, and further research is warranted. This paper highlights the components and pharmacological functions of CSR, with the aim to provide a comprehensive review and useful data for future studies and for the development of relevant food products.

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Inhibitory activities of some traditional Chinese herbs against testosterone 5α-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice

Cited by 32 publications

References 21 publications

Hair Growth-promoting Effect of Resina Pini and Its Main Constituent, Abietic Acid, in Mouse Model of Alopecia

Hair Growth-promoting Effect of Resina Pini and Its Main Constituent, Abietic Acid, in Mouse Model of Alopecia

Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA‐5512 Effectively Stimulates Hair Growth and Promotes Hair Health

A Phytochemical and Pharmacological Review on Cynomorium songaricum as Functional and Medicinal Food

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