Inhibition of the Sensitizing Effect of Carvone by the Addition of Non-Allergenic Compounds

Abstract

We have previously reported a reduction of sensitization to carvone in guinea pigs when adding non-allergenic, structurally related compounds simultaneously at induction. This study investigates the criteria needed to obtain a reduction of sensitization in contact allergy. Linalool, a non-sensitizer structurally unrelated to carvone, significantly reduced the sensitizing capacity of carvone in guinea pigs. The effect of different concentrations of inhibitors in mixtures with carvone was investigated. No significant differences in response were obtained between the concentrations explored. A possible anti-inflammatory effect from the inhibitory chemicals was investigated in vitro. No suppression of the immune system was seen. This study shows that a non-allergenic compound with a structure not resembling the hapten can reduce the sensitizing effect of the hapten. It indicates that reduction of an allergenic effect might occur in consumer products that are mixtures of different chemicals. Further studies with chemically unrelated compounds with and without allergenic effect are needed.

Exploring Pharmacological Mechanisms of Essential Oils on the Central Nervous System

“…However, conflicting results were by several research groups. For instance, carvone, a fragrant ingredient and a well-known sensitizer (mechanism for antigen formation is described) [ 139 ], was found to be inhibited by structural and non-structural analogs in guinea pigs [ 140 , 141 ]. On the other hand, studies on guinea pigs revealed no quenching of cinnamic aldehyde and citral [ 142 ].…”