Inhibition of reinstatement of alcohol-induced conditioned place preference in mice by <i>Lonicera japonica</i> polysaccharide

Liu, Ping; Shen, Hengyang; Zhang, Qiaoyue; Zhou, Limei; Bai, Xinyu; Zhang, Tao

doi:10.1039/d2fo01719a

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…Taken together, LJP-s inhibited the activation of autophagy in the hippocampus by mediating VPS34 phosphorylation, thereby reducing the occurrence of alcohol-related diseases. Moreover, the Nissl assay and immunofluorescence staining results indicated that LJP-s alleviated nerve injury and pathologic changes [ 38 ]. Therefore, LJP-s could be used as an anti-alcohol-addiction agent and in new functional foods.…”

Section: Health Benefits Of L Japonica Polysacchar...mentioning

confidence: 99%

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

Yang,

Yu,

et al. 2023

Molecules

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Lonicera japonica Thunb. is a widely distributed plant with ornamental, economic, edible, and medicinal values. L. japonica is a phytoantibiotic with broad-spectrum antibacterial activity and a potent therapeutic effect on various infectious diseases. The anti-diabetic, anti-Alzheimer’s disease, anti-depression, antioxidative, immunoregulatory, anti-tumor, anti-inflammatory, anti-allergic, anti-gout, and anti-alcohol-addiction effects of L. japonica can also be explained by bioactive polysaccharides isolated from this plant. Several researchers have determined the molecular weight, chemical structure, and monosaccharide composition and ratio of L. japonica polysaccharides by water extraction and alcohol precipitation, enzyme-assisted extraction (EAE) and chromatography. This article searched in the Chinese Pharmacopoeia, Flora of China, Web of Science, PubMed, and CNKI databases within the last 12 years, using “Lonicera. japonica polysaccharides”, “Lonicera. japonica Thunb. polysaccharides”, and “Honeysuckle polysaccharides” as the key word, systematically reviewed the extraction and purification methods, structural characteristics, structure-activity relationship, and health benefits of L. japonica polysaccharides to provide insights for future studies. Further, we elaborated on the potential applications of L. japonica polysaccharides in the food, medicine, and daily chemical industry, such as using L. japonica as raw material to make lozenges, soy sauce and toothpaste, etc. This review will be a useful reference for the further optimization of functional products developed from L. japonica polysaccharides.

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Section: Health Benefits Of L Japonica Polysacchar...mentioning

confidence: 99%

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

Yang,

Yu,

et al. 2023

Molecules

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“…In recent years, polysaccharides from Lonicera japonica Thunb. have attracted considerable attention due to their diverse biological activities such as anti-tumor, immunomodulation, anti-inflammatory, anti-oxidant, and other biological activities (5)(6)(7)(8)(9)(10). Pectin is a family of galacturonic acid-rich polysaccharides found in the primary cell wall of plants (11).…”

Section: Introductionmentioning

confidence: 99%

“…Liu et al isolated a pectic polysaccharide (LFA03-a) from Lonicera japonica Thunb. Structural analysis revealed that it possessed a RG-I backbone and substituted at O-4 of L-rhamnose with β-D-1,4-Galp, β-D-1,3-Galp, β-D-1,3,6-Galp, and α-L-1,5-Araf side chains ( 6 ). In addition, Zhang et al purified one neutral fraction (LJP-N) and four acidic fractions (LJP-A-1 ∼ LJP-A-4) from Lonicera japonica Thunb.…”

Section: Introductionmentioning

confidence: 99%

Structural characterization and anti-oxidation activity evaluation of pectin from Lonicera japonica Thunb.

Wang

et al. 2022

Front. Nutr.

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Pectins are nutrient components of plants and are widely used in the food industry. In this study, one major pectin fraction (WLJP-A0.2b) with Mw of 40.6 kDa was purified from Lonicera japonica Thunb. The structural feature and antioxidant activity of it was investigated. Monosaccharide composition, Fourier transform infrared (FT-IR) spectra, enzymatic hydrolysis, and nuclear magnetic resonance (NMR) spectra analysis indicated that WLJP-A0.2b consisted of rhamnogalacturonan I (RG-I), rhamnogalacturonan II (RG-II), and homogalacturonan (HG) domains, with mass ratio of 0.4:1.0:2.1. The RG-I domain contained highly branched α-L-1,5-arabinan, β-D-1,4-galactan and type II arabinogalactan (AG-II) side chains. The HG domain was released in the form of un-esterified and partly methyl-esterified and/or acetyl-esterified oligogalacturonides with degree of polymerization 1–8 after degradation by endo-polygalacturonase. Radical scavenging assays indicated that WLJP-A0.2b exhibited antioxidant activity through the synergistic effects of different pectin domains. Oligogalacturonides, especially de-esterified oligogalacturonides, showed better antioxidant activities than RG-II and RG-I domains. Moreover, de-esterified oligogalacturonides remarkably reduced H2O2-induced reactive oxygen species production in HEK-293T cells. These results provide useful information for screening of natural antioxidants from Lonicera japonica Thunb. and application of pectin in functional food field.

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Inhibition of reinstatement of alcohol-induced conditioned place preference in mice by Lonicera japonica polysaccharide

Abstract: Alcohol is one of the most commonly used addictive substances. Addiction memory is a necessary part of the mechanism underlying drug addiction. Lonicera japonica and its extract can mitigate organ...

Cited by 2 publications

References 28 publications

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

Structural characterization and anti-oxidation activity evaluation of pectin from Lonicera japonica Thunb.

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