Inhibition of rat vas deferens contractions by flavonoids in-vitro

Capasso, Raffaele; Fiorino, Ferdinando; Ascione, Valeria; Frecentese, Francesco; Borrelli, Francesca

doi:10.1211/jpp.58.3.0013

Cited by 17 publications

(9 citation statements)

References 16 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…31) Due to the presence of different substituents on the carbon atoms of the basic skeleton, flavonoids may have different activities and potencies. 32) According to our results, flavonols (quercetin, morin, myricetin, kaempferol) are present of C-2-C-3 double bond with hydroxyl groups in position 3, 5 and 7. They were active in the hypouricemic and XOD inhibitory properties in hyperuricemic mice.…”

Section: Fig 1 Effects Of Flavonoids On Liver Uric Acid Levelsmentioning

confidence: 55%

Hypouricemic Action of Selected Flavonoids in Mice: Structure-Activity Relationships

Zhou

et al. 2007

Biological & Pharmaceutical Bulletin

154

104

View full text Add to dashboard Cite

Gout occurs in individuals who have high serum uric acid levels, in response to precipitation of monosodium urate monohydrate crystals in various tissues, followed by an inflammatory response. 1) The essence of the prevention and treatment of gout is antihyperuricemic therapy, either by uricosuric drugs or by xanthine oxidase (XOD) inhibitors. Allopurinol, an XOD inhibitor which is structurally related to xanthine, binds tightly to the active site of XOD thus causes inhibition on XOD. Allopurinol is used to treat gout for more than 40 years and remains a cornerstone in the therapy of primary and secondary hyperuricemia. 2-7) However, the most common adverse effects of allopurinol are gastrointestinal distress, hypersensitivity reactions, 8) and renal toxicity. 9) Thus, new alternatives with an increased therapeutic activity and less side effects are desired.Dietary flavonoids have been attracted attention because of their potential beneficial effects on human health. The structural components common to these molecules include two benzene rings on either side of a 3-carbon ring (Table 1). 10) Multiple combinations of hydroxyl groups, sugars, oxygens, and methyl groups attached to these structures create the various classes of flavonoids: flavanols, flavanones, flavones, flavanonol, flavan-3-ols (catechins), anthocyanins, and isoflavones. 11) Flavonoids are well known to possess antiviral, antiallergic, antiplatelet, antiinflammatory, antitumor and antioxidant activities. 12-15) Catechin and its derivatives, oligomeric proanthocyanidins, quercetin and quercetin chalcone, Ginkgo flavone glycosides, silymarin, and others can be utilized in preventative and treatment protocols for cardiovascular disease, cancer, inflammatory conditions, asthma, periodontal disease, liver disease, cataracts and macular degeneration. 16,17) Hyperuricemia is a risk factor for the disorder metabolic syndrome and increased cardiovascular disease, and the mechanisms involve inflammation and generation of oxidative stress in the vasculature. 18) Thus, the antiinflammatory and antioxidant activities of flavonoids might bring benefit for hyperuricemia and its complications. In addition, the flavonoids have increasingly aroused interest recently for their hypouricemic action in hyperuricemic animal models. [19][20][21] In the present study, we have explored hypouricemic actions from 15 flavonoids including quercetin, morin, myricetin, kaempferol, icariin, apigenin, luteolin, baicalin, silibinin, naringenin, formonoetin, genistein, puerarin, daidzin and naringin dihydrochalcone in a hyperuricemic animal model induced by potassium oxonate. We have also studied the effects of six most active compounds on serum and liver uric acid levels in normal mice. The effects on liver XOD activities were further examined in animals. MATERIALS AND METHODSMaterials Quercetin, morin, myricetin, kaempferol, icariin, apigenin, luteolin, baicalin, silibinin, naringenin, formonoetin, genistein, puerarin, daidzin and naringin dihydrochalcone were obtained commerci...

show abstract

Section: Fig 1 Effects Of Flavonoids On Liver Uric Acid Levelsmentioning

confidence: 55%

Hypouricemic Action of Selected Flavonoids in Mice: Structure-Activity Relationships

Zhou

et al. 2007

Biological & Pharmaceutical Bulletin

154

104

View full text Add to dashboard Cite

show abstract

“…[5][6][7][8][9][10][11] Quercetin has also been proposed for the treatment of chronic rhinosinusitis. [12] Previous studies have shown that quercetin exerts inhibitory effects on rat vas deferens, [13] vascular tissues [14] and intestinal contractility. [15] Notably, a structure-activity relationship for a number of flavonoids, including quercetin, has been also reported.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of quercetin on rat trachea contractility <I>in vitro</I>

Capasso¹,

Aviello²,

Romano³

et al. 2009

j pharm pharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Flavonoids are plant metabolites with benzo-gamma-pyrone structure, which are found ubiquitously in all parts of plants 9 . Flavonoids are known to exert beneficial effects such as decrease total cholesterol, improve control of blood glucose concentration, and help in weight control in diabetic patients 10 .…”

Section: Introductionmentioning

confidence: 99%

Effects of Naringenin on Lipogenesis, Lipolysis and Glucose Uptake in Rat Adipocyte Primary Culture: A natural antidiabetic agent

2008

IJAM

View full text Add to dashboard Cite

CitationS Lim, K Soh, U Kuppusamy. Effects of Naringenin on Lipogenesis, Lipolysis and Glucose Uptake in Rat Adipocyte Primary Culture: A natural antidiabetic agent. AbstractThe flavonoid naringenin is commonly found in citrus fruits and tomato. The main aim of this study was to assess the in vitro insulin-like effects of naringenin using rat adipocyte primary culture. The adipogenic, lipolytic and glucose uptake activities of naringenin in primary rat adipocytes were assessed using Oil Red O, glycerol, and 2-deoxy-D-[2,6-3 H]glucose uptake quantitative assays respectively. Naringenin exhibited significant increase of lipogenesis in the presence and absence of insulin in primary rat preadipocytes. At the concentration range of 0.01 -100 µM, naringenin inhibited 50 % of epinephrine induced lipolysis in rat adipocytes and enhanced insulin's antilipolytic activity. Naringenin (100 µM) stimulated 163 % glucose uptake in rat adipocytes (compared to untreated cells) and this was significantly higher than the insulin mediated glucose uptake at similar concentration. Thus, naringenin may play an important role as an adjuvant and/or alternative to insulin therapy for the management of diabetes mellitus.

show abstract

Inhibition of rat vas deferens contractions by flavonoids in-vitro

Cited by 17 publications

References 16 publications

Hypouricemic Action of Selected Flavonoids in Mice: Structure-Activity Relationships

Hypouricemic Action of Selected Flavonoids in Mice: Structure-Activity Relationships

Inhibitory effect of quercetin on rat trachea contractility <I>in vitro</I>

Effects of Naringenin on Lipogenesis, Lipolysis and Glucose Uptake in Rat Adipocyte Primary Culture: A natural antidiabetic agent

Contact Info

Product

Resources

About