Inhibition of lipid oxidation by encapsulation of emulsion droplets within hydrogel microspheres

Extending Emulsion Functionality: Post-Homogenization Modification of Droplet Properties

“…As a result, approximately spherical biopolymer particles are formed that contain the oil droplets inside. Studies have shown that oil droplets trapped in this type of biopolymer particle are more stable to lipid oxidation [69][70][71], and that the rate of lipid digestion under simulated gastrointestinal conditions is reduced [67,72]. This latter property may be useful for developing delivery systems for lipophilic bioactive components intended for release in the colon.…”

“…The inner aqueous phase was then gelled by adding calcium ions, and stabilized by reducing the pH to induce adsorption of a layer of pectin molecules around the caseinate-rich droplets. It was shown that the oil droplets within the hydrogel beads could be protected from lipid oxidation [70], but that they would still be released under simulated gastrointestinal conditions [83], which is important for the development of effective encapsulation systems. Phase separation of gelatin-starch systems has also been utilized to produce filled hydrogel beads based on the thermodynamic incompatibility mechanism [84].…”

Development of food-grade filled hydrogels for oral delivery of lipophilic active ingredients: pH-triggered release

“…Lipid droplets are trapped within hydrogel microspheres (W 1 ), which themselves are suspended within a continuous aqueous phase (W 2 ). In recent studies, we have successfully fabricated fish oil loaded hydrogel particles based on complex coacervation of caseinate and LM-pectin (Matalanis, Decker, & McClements, 2012). Encapsulation of fish oil within filled hydrogel particles improved their stability to lipid oxidation compared to conventional emulsions.…”

Designing hydrogel particles for controlled or targeted release of lipophilic bioactive agents in the gastrointestinal tract

“…For example, the oxidation of polyunsaturated lipids may be retarded by using antioxidant biopolymers, such as proteins, to form the hydrogel matrix surrounding the bioactives [6,7].…”