Inhibition of hypersensitivity reactions by a new drug, N(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′)

Koda, Akihide; Nagai, Hiroichi; Watanabe, Shigekatsu; Yanagihara, Yukiyoshi; Sakamoto, Kenichi

doi:10.1016/0091-6749(76)90054-3

Cited by 182 publications

(67 citation statements)

References 7 publications

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“…These results indicate that mesenteric mast cells release higher rates of histamine than peritoneal mast cells. The effect of tranilast, an anti-allergenic agent [1,6], on the histamine release was examined. Mesenterium specimens were incubated with 1 µg antigen for 15 min.…”

Section: Japanmentioning

confidence: 99%

High Rate of IgE-Mediated Histamine Release from Rat Mesenteric Mast Cells.

2001

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IgE-dependent histamine release from rat mesenteric mast cells was investigated. Excised mesenterium was cut into pieces and incubated with IgE overnight at 4°C for sensitization. Over 10 pieces of mesenterium specimen could be prepared from a rat. Antigen-induced histamine release from mesenterium specimen was initiated rapidly and reached a plateau in 5 min. In an optimal condition, over 50% of total histamine was released. In contrast, unpurified and purified peritoneal mast cells released only 22.5% and 5.3% of total histamine, respectively, upon IgE stimulation. Tranilast, a mast cell stabilizer, inhibited the histamine release from mesenteric mast cells significantly. The mesenterium might be a useful material for studying tissue-associated mast cell activation.

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Section: Japanmentioning

confidence: 99%

High Rate of IgE-Mediated Histamine Release from Rat Mesenteric Mast Cells.

2001

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“…Homologous passive cutaneous ana phylaxis (PCA) in rats: Homologous PCA in rats was carried out according to the method previously described (8). Antiserum containing homocytotropic antibody was obtained from rats that had been immunized with 2,4-dinitrophenyl-coupled ascaris (DNP As) mixed with killed Bordetella pertussis according to Tada and Okumura (9).…”

Section: Animalsmentioning

confidence: 99%

“…Contact dermatitis in guinea pigs: This experiment was carried out according to the method described previously (8). Guinea pigs were sensitized by iontophoresis of p phenylenediamine (p-PD).…”

Section: Degranulationmentioning

confidence: 99%

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Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). I. Anti-allergic action.

Nagai

Saito²,

Matsuura

et al. 1982

Jpn.J.Pharmacol

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Abstract-Effect of the aqueous extract of Cinnamomum Cassia (CCAq) on experimental allergic reaction was investigated. IgE mediated reactions, homologous passive cutaneous anaphylaxis (PCA), degranulation of mast cells, and the release of histamine from sensitized lung tissues classified as the type I reaction by Coombs and Gell were not affected by CCAq. Com plement dependent reactions including reversed cutaneous anaphylaxis (RCA), Forssman cutaneous vasculitis (FCV), and nephrotoxic serum (NTS) nephritis classified as type II and the Arthus reaction classified as type III were clearly inhibited by CCAq. However, CCAq did not affect the nephritis caused by the F(ab')2 portion of the nephrotoxic IgG antibody. CCAq in a high concentration inhibited the immunological hemolysis, chemotactic migration of neutrophils in response to complement activated serum, and the generation of chemotactic factors. The type IV reaction, contact dermatitis, was not affected by CCAq. The production of hemolytic plaque forming cells was slightly inhibited by CCAq. These results suggest that CCAq has an anticomplement action and inhibits the complement dependent allergic reaction.

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“…Such being the case, drugs with a mechanism similar to that of DSCG and are which effective when given orally are most feasible for treatment of patients with asthma, particularly children. Several reports on such drugs have been made (1,(3)(4)(5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

Inhibition of homologous passive cutaneous anaphylaxis (PCA) by disodium cromoglycate-related compounds.

1980

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Abstract-A study was conducted to examine the effect on homologous PCA in rats of 14 different, newly synthesized compounds, given orally, in relation to the chemical structure of DSCG, when given orally on homologous PCA in rats. The structure activity relationship of these compounds was also discussed. Among the 7 compounds of the glycerol bischromenonyl ether derivatives, 1,3-bis (2-phenyl-4-chromenon-5-yl) oxypropane-2-ol (compound 1) showed the most potent inhibitory activity on PCA. The other compounds showed a moderate or no effect. Two compounds of glycerol bisphenyl ether derivatives had little effect. On the other hand, 1,3-bis (2-carboxy-3 hydroxyphenyl)oxypropane (compound 11) out of alkandiol bisphenyl ether derivatives significantly inhibited PCA, and the other 4 compounds showed a tendency toward inhibition of the reaction. The late inhibition, seen in the biphasic inhibitory pattern induced by compound 11, may be caused by a certain active substance transformed in the body.We have already reported a comparative study on the anti-allergic effects of disodium baicalein 6-phosphate (BPS) as a monochromone derivative, and of disodium cromoglycate (DSCG) as a dichromone derivative. BPS inhibited not only reaginic (IgE) antibody mediated reactions, including antigen-induced mediator release from monkey lung, homologous passive cutaneous anaphylaxis (PCA) in rats, and IgE antibody-mediated degranulation of mast cells, but also non-reaginic antibody-mediated reactions such as mediator release from both guinea pig lung sensitized with egg albumin and human lung caused by anti-IgE. Conversely, DSCG showed characteristic properties as an inhibitor of IgE antibody-mediated reaction. From these findings, it was suggested that the functional site of IgE antibody appears to interact with DSCG, with a definite distance between the two chromone-nuclei ; while the site of the non-reaginic antibody, IgG, is shorter or longer than that of IgE antibody and is readily fixed with two molecules of BPS (1).Meanwhile, the development of DSCG contributed greatly to the therapy for asthma, particulary atopic type asthma (2). The drug, however, is ineffective when given orally, as it is poorly absorbed from the gastrointestinal tract. Such being the case, drugs with a mechanism similar to that of DSCG and are which effective when given orally are most feasible for treatment of patients with asthma, particularly children. Several reports on such drugs have been made (1, 3-9).The present paper describes the effect of oral ingestion of newly synthesized compounds in relation to the chemical structure of DSCG on homologous PCA in rats using their IgE

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Inhibition of hypersensitivity reactions by a new drug, N(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′)

Cited by 182 publications

References 7 publications

High Rate of IgE-Mediated Histamine Release from Rat Mesenteric Mast Cells.

High Rate of IgE-Mediated Histamine Release from Rat Mesenteric Mast Cells.

Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). I. Anti-allergic action.

Inhibition of homologous passive cutaneous anaphylaxis (PCA) by disodium cromoglycate-related compounds.

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