No abstract

Abstract-A comparative study was carried out on the effects of a soluble derivative of baicalein, disodium baicalein 6-phosphate (BPS) and disodium cromoglycate (DSCG) on the immediate type allergic reactions.BPS not only inhibited reaginic antibody mediated reactions including antigen-induced mediator release from monkey lung, homologous PCA in rats, and reaginic antibody-mediated degranulation of mast cell, but also non-reaginic antibody-mediated reactions such as mediator release from guinea pig lung sensitized with ovalbumin and that from human lung caused by anti IgE. The agent, however, did not affect the mediator release from lung of rats sensitized with dinitrophynylated ascaris extract plus Bordetella pertussis. On the other hand, DSCG showed characteristic properties as an inhibitor of reaginic antibody-mediated reaction.It is thus assumed that the functional site of reaginic antibody is well fixed with DSCG at a definite distance between the two-chromone-nuclei while that of IgG is readily fixed with the two molecules of baicalein or BPS.Baicalein and baicalin are flavones contained in the radix of Scutellaria baicalensis GEORGI (Woogon), which from ancient times has often been used in Chinese medicine as a remedy for allergic diseases and inflammation. We (1-5) have already reported the anti allergic activity of baicalein and its derivatives, and these substances also have a potent protective action against active and passive anaphylaxis. These agents were also found to inhibit reagin-mediated reaction as well as disodium cromoglycate (DSCG). DSCG does inhibit reagin-mediated reaction with a fairly high specificity (6-12), however, inhibits not at all or only slightly non-reaginic antibody-mediated reactions (7-12) and the mediator release by specific antigen from the leucocytes of allergic patient (13).From the viewpoint of chemical structures, baicalein is a monochromone derivative while DSCG is a symmetric dichromone derivative, as shown in Fig. 1

SP and NKA, which are released early after the challenge, mediate the development of NHR by preferentially activating NK(2) receptors. Therefore, NK(2) receptor antagonists might prove to be effective treatment of AR.

IgG subclasses were determined in 138 A or B infants weighing over 2,500g, born to O mothers. Direct antiglobulin test (DAT) was positive in 43 infants and negative in 95 with anti-A and/or anti-B antibodies detected by heat elution test. In 59 out of 131 infants without ABO hemolytic disease (ABO-HDN), no IgG subclass was detectable. In the 72 others, IgG1 was found in 29/72, IgG2 in 63/72, and IgG3 was not detected. In 7 infants with ABO-HDN, DAT was positive in 4 and negative in 3. In conclusion, in DAT-positive infants without HDN, IgG1 or IgG2 may be bound to erythrocytes, but the amount of IgG1 is too small to cause hemolysis. In DAT-positive ABO-HDN the amount of IgG1 is sufficient to cause hemolysis. In DAT-negative ABO-HDN, IgG3 is responsible for hemolysis, even though undetectable by DAT.

No abstract