Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). I. Anti-allergic action.

Nagai, Hiroichi; Saito, Tsukasa; Matsuura, Naosuke; Koda, Akihide

doi:10.1254/jjp.32.813

Cited by 28 publications

(16 citation statements)

References 16 publications

(14 reference statements)

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“…RCA was carded out according to the method previously described by Nagai et al (1982). RCA was induced by the intradermal injection of 0.05 ml of 14% rabbit rat antiserum into shaved rat skin.…”

Section: Methodsmentioning

confidence: 99%

Effect of triphenyltin chloride on the release of histamine from mast cells

1992

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The effects of triphenyltin chloride (TPTC) on the release of histamine from rat and mouse mast cells in vitro and in vivo were investigated. The results obtained are summarized as follows: (a) At doses between 1 and 3 mg/kg, TPTC inhibited the dye leakage due to passive cutaneous anaphylaxis mediated by IgE antibody in mouse ear. At the same doses, TPTC inhibited the swelling due to reversed cutaneous anaphylaxis mediated by IgG antibody in rat. However, TPTC did not affect dye leakage due to histamine, serotonin, and LTC4 in rat skin; (b) Histamine release by antigen and IgE antibody in rat peritoneal cavity was inhibited by the administration of TPTC at doses between 0.3 and 3 mg/kg; (c) Histamine release by calcium ionophore A 23187 from purified rat peritoneal mast cells in vitro was inhibited by TPTC at concentrations between 10(-7) and 10(-6) M. At the same concentration, TPTC, itself, caused neither the release of histamine nor any change in cell viability which was supported by the activity of lactate dehydrogenase (LDH) from purified rat peritoneal mast cells. All this evidence suggests that TPTC has an inhibitory effect on the release of histamine from mast cells without direct cytotoxicity.

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Section: Methodsmentioning

confidence: 99%

Effect of triphenyltin chloride on the release of histamine from mast cells

1992

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“…Drug: CCAq was prepared by the previ ously described method (1). In brief, 100 g of finely cut Cinnamomum Cassia was ex tracted with 1 I of distilled water by heating at 60°C for 4 hr.…”

Section: Methodsmentioning

confidence: 99%

“…Nephrotoxic serum (NTS) nephritis in rats: The preparation of NTS and production of NTS nephritis were done by the same method previously reported (1). NTS was obtained from rabbits immunized by in jection of the glomerular basement membrane rich sediment of rat kidney emulsified with complete Freund's adjuvant (CFA).…”

Section: Methodsmentioning

confidence: 99%

“…In a previous paper, we reported the inhibitory actions of the aqueous extract of Cinnamomum Cassia (CCAq) on complement dependent allergic reactions in vitro and in vivo (1). According to Johnson, anti complement agents should be useful not only for treating transplantation rejection, but also for alleviating autoimmune disease or immune complex (IC) disease caused by the activation of complement system (2).…”

Section: Abstract-effectmentioning

confidence: 99%

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Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). II. Effect of CCAq on experimental glomerulonephritis.

Nagai

Saito²,

Takizawa

et al. 1982

Jpn.J.Pharmacol

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Abstract-Effectof the aqueous extract of Cinnamomum Cassia (CCAq) on experimental glomerulonephritis was studied and compared with that of cobra venom factor (CoVF). In rat nephrotoxic serum (NTS) nephritis, CCAq clearly inhibited the excretion of protein into the urine and the increase of peripheral leucocyte counts. The histological score in CCAq administered animals was significantly lower than that in control animals. However, CCAq did not inhibit or lower the serum complement level. Contrary to CCAq, hypocomplementation was observed by the administration of CoVF, and the excretion of protein into urine was inhibited in a high dose group. In immune complex (IC) and autologous IC nephritis in rats, CCAq clearly inhibited the excretion of protein into urine and the elevation of blood urea nitrogen (BUN). The administration of CoVF caused hypocomplementation, but little inhibition of the excretion of urinary protein was observed in both types of immune complex nephritis. The histological score was slightly inhibited by a low dose of CCAq and a high dose of CoVF. In the experi ment employing NZB/NZW F, mice, the proteinurea, the elevation of BUN level, and the production of antibodies were clearly inhibited by the adminis tration of CCAq. Similar inhibition was observed by CoVF at a high dose.

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“…The diterpene in the oil have anti allergic activity, help reduce ulcers and augments the action of insulin. 5 Interestingly, it is also powerful antioxidant. 6 In human with type 2 diabetes, consumption of as little as 1 gm of cinnamon per day was found to reduce blood sugar, triglycerides, LDLcholesterol and total cholesterol.…”

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confidence: 99%