Inhibition of Huggins Tumors by Forced Restraint

Newberry, Benjamin H.; Gildow, Joseph; Wogan, James; Reese, Randy L.

doi:10.1097/00006842-197605000-00001

Cited by 27 publications

(19 citation statements)

References 10 publications

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“…It should be noted, however, that although we previously found that 10 inescapable shock sessions had effects that went beyond simply blocking the acute stress-induced tumor enhancement and actually inhibited tumor growth relative to nonshocked controls such an effect was not evident in the present experiment. This is not entirely surprising, in view of the fact that the inhibition we previously observed was quite small and the chronic stress regimens typically employed in studies reporting inhibited tumor growth are considerably more extensive (see [30][31][32][33][34][35][36][37][38][39][40][41][42].…”

Section: Methodsmentioning

confidence: 78%

“…With respect to the infra-human investigations, it has been reported that stress may either exacerbate (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) or inhibit (14,(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42) tumorigenicity. Aside from stress type and social conditions (2,43), two important factors that contribute to these contradictory findings are ability to control stress and chronicity of stress.…”

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confidence: 99%

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Adaptation to the Tumor-Enhancing Effects of Stress

Sklar¹,

Bruto²,

Anisman³

1981

Psychosomatic Medicine

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Growth of P815 mastocytoma in syngeneic DBA/2J male mice was evaluated following several stress regimens. Although escapable shock did not enhance tumor growth, an equivalent amount of inescapable shock applied in a yoked paradigm markedly augmented tumor development. If mice received repeated stress sessions on 5-10 consecutive following tumor cell transplantation, the tumor-enhancing effects of an acute session were abrogated. This effect was not due to an antitumor effect exerted by a shock session applied several days after cell transplantation. It seems that the tumorigenic effects of stress are subject to adaptation since stress exposure prior to cell transplantation also inhibited the effects of an acute stress session. The data were discussed in relation to stress-induced neurochemical alterations.

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Section: Methodsmentioning

confidence: 78%

mentioning

confidence: 99%

Adaptation to the Tumor-Enhancing Effects of Stress

Sklar¹,

Bruto²,

Anisman³

1981

Psychosomatic Medicine

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“…Henry et al found rapid cancer cell growth in mice kept in isolation, 4 and Newberry et al reported on the effects of electric shock on tumor formation in rats. 5 Riley et al observed the influence of stress on tumor formation and suggested the importance of adrenocortical hormones as its mechanism. 6 In those studies, which used physical stimuli such as strong light stimulation or electric shock, immune function was not directly measured.…”

Section: Discussionmentioning

confidence: 99%

“…If psychological stress interferes with this function, a tumor may be allowed to grow to a size that immune system can no longer deal with easily. [3][4][5][6][7][8][9][10][11][12][13] In recent years, exercise and training have been studied as factors affecting immune responses. [14][15][16][17][18][19][20] We have performed sports rehabilitation for patients with coronary heart disease from the aspect of exercise psychology.…”

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confidence: 99%

Immune Function and Psychological Factors in Patients With Coronary Heart Disease (I)

et al. 1999

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“…Experimental studies carried out on animals proved tumour-inhibitory (Newberry et al 1972(Newberry et al , 1976 as well as tumour-stimulatory effect (Tejwani et al 1991;Kavetsky et al 1966) of psychosocial factors on mammary tumourigenesis. Activation of the hypothalamicpituitary-adrenal system and sympathetic nervous system due to stress results in an increased production of catecholamines and glucocorticoids and consequent negative effects on functions of the immune system.…”

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confidence: 97%

Effect of a Short-Term and Long-Term Melatonin Administration on Mammary Carcinogenesis in Female Sprague-Dawley Rats Influenced by Repeated Psychoemotional Stress

Kassayová

Adámeková²,

Bojková

et al. 2007

Acta Vet. Brno

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The aim of this study was to evaluate the effect of melatonin (MEL) on N-methyl-N-nitrosourea (NMU)-induced mammary carcinogenesis in female Sprague-Dawley rats exposed to repeated psychoemotional stress -immobilization in boxes. NMU was applied intraperitoneally in two doses each of 50 mg/kg b.w. between 40 -50 postnatal days. Melatonin was administered in drinking water at a concentration of 4 μg/ml daily from 15:00 h to 8:00 h. The application was initiated 5 days prior to the fi rst NMU dose and lasted 15 days, i.e. during the promotion phase of tumour development, or long-term until the end of the experiment (week 20). Immobilization (2 h per day) began on the third day after the second carcinogen application and lasted for 7 consecutive days.Short-term MEL administration to immobilized animals increased incidence by 22%, decreased tumour frequency per animal by 26% and reduced tumour volume gain (by 21%) when compared to the immobilized group without MEL application. Decreased frequency per animal by 28% and more than a 40% decrease in tumour volume gain and cumulative volume were the most pronounced changes in the animals drinking MEL until the end of the experiment.Long-term MEL administration reduced the number and size of mammary tumours more markedly than its short-term administration. Melatonin decreased certain attributes of mammary carcinogenesis in female rats infl uenced by psychoemotional stress. Melatonin, mammary carcinogenesis, psychoemotional stress -restraint, ratBreast cancer is the most frequently diagnosed tumour in women world-wide. In most European countries the incidence is increasing; 350 000 new cases are recorded annually and annual mortality rate is 130 000 (Tyczynski et al. 2004). Chemically induced mammary carcinogenesis in rats is a widely used model to study preventive and therapeutic effects of various substances on tumour development. Melatonin (MEL) has been one of the most discussed substances since the 1970's. Melatonin is an endogenous pineal gland hormone and its oncostatic properties were proved mainly in hormone-sensitive mammary tumour in vivo and in vitro.Tumour-suppressive effects of MEL are exerted by different mechanisms of action. Indirect effect of MEL is produced through its inhibition of the activity of neuroendocrinereproductive axis with a consequent decrease in circulating levels of hormones that stimulate mammary tissue proliferation, mainly estrogens and prolactin (Tamarkin et al. 1981). MEL is capable of direct interaction with estrogen receptors resulting in their expression decrease and modulation of estrogen signal transfer

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Inhibition of Huggins Tumors by Forced Restraint

Cited by 27 publications

References 10 publications

Adaptation to the Tumor-Enhancing Effects of Stress

Adaptation to the Tumor-Enhancing Effects of Stress

Immune Function and Psychological Factors in Patients With Coronary Heart Disease (I)

Effect of a Short-Term and Long-Term Melatonin Administration on Mammary Carcinogenesis in Female Sprague-Dawley Rats Influenced by Repeated Psychoemotional Stress

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