Immune Function and Psychological Factors in Patients With Coronary Heart Disease (I)

Ishihara, Shunichi; Nohara, Ryuji; Makita, Shigeru; Imai, Masaru; Kubo, Shigeru; Hashimoto, Takeji

doi:10.1253/jcj.63.704

Cited by 16 publications

(13 citation statements)

References 25 publications

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“…BDI scores of the primary infertile group was significantly lower than those of the secondary infertile group. On the other hand immunological investigations on psychoneurosis have demonstrated the potential impact of psychological factors on immunity (22,23). For instance, natural killer cell (NK) activity has been determined as the main factor in premature termination of pregnancy (24,25).…”

Section: Discussionmentioning

confidence: 99%

Psychologic and sexual dysfunction in primary and secondary infertile male patients

Şahin¹,

Ürkmez²,

Verit³

et al. 2017

Arch Ital Urol Androl

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Objective: The aim of this study was to compare depression and sexual dysfunctions observed in primary and secondary infertile patients. Material and method: The study was performed in 39 primary and 31 secondary infertile male patients. Male sexual health was evaluated using the International Index of Erectile Function (IIEF) score and depression with Beck Depression Inventory (BDI). Results: Mean age of the participants and their partners were 31.54 ± 5.37 (range, 24-48 yrs), and 28.16 ± 5.58 (range, 20-46 yrs) years, respectively. Mean duration of their marriage ranged between 1 and 17 years (mean, 5.06 ± 4.15 yrs). A statistically significant intergroup difference was detected between groups as for BDI scores (p = 0.015; p < 0. 05). BDI scores of the primary group were significantly lower than those of the secondary group. A statistically and extremely significant difference was detected between IIEF scores of the groups (p = 0.006; p < 0.01). IIEF scores of the primary infertile group were higher than those of the secondary group. Conclusion: Our study, frequency of the depression and erectile dysfunction seen in the patients with secondary infertility was seen significantly higher than the patients with primary infertility.KEY WORDS: Infertility; Male sexual dysfunction; Depression; Secondary infertile man. clear definition of this time, the 12 months period is also accepted for the secondary infertility by many authors. Diagnosis of infertility can be made in nearly 15% of the couples who want to have a baby and primary or secondary infertility are detected in 90 and 10% of them (3). One of the basic and primitive instincts in human beings is reproductive instinct. Reproductive deficiency frequently creates a social stigma, which is perceived as a disgraceful condition (4). Infertility emerges from a sudden and unexpected life crisis, which can be diagnosed in the long run. It results in excessive stressful problems, which strain adjustment mechanisms (5). Studies analyzing the association between infertility and psychological functions have used one of the following models. One of them is psychological infertility model, which asserts the role of an existing psychopathology on the etiology of infertility and the other model (psychological result) claims that psychological problems arise as a result of infertility (6). Recently direct correlation of mental stress with infertility problems and its impact on the outcomes of infertility treatment has been demonstrated. For example it has been revealed that during natural disasters like earthquakes, sperm quality activities of seminal plasma superoxide dismutase and arginine decrease, and nitric oxide levels increase in men under stress (7,8). Since psychiatric disorders are more frequently analyzed during infertility investigations, scales specific to infertility process haven't been developed yet (9). In developed countries, it appears to be appropriate to take a detailed history about psychological status of the infertile couple. The rationale of this appr...

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Section: Discussionmentioning

confidence: 99%

Psychologic and sexual dysfunction in primary and secondary infertile male patients

Şahin¹,

Ürkmez²,

Verit³

et al. 2017

Arch Ital Urol Androl

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“…Psychological factors can change immune responses (7)(8)(9)(10)(11)(12). Matsubayashi et al (16) found no statistically significant correlation of increased NK cell activity in infertile women with existing depression scores on the Profile of Mood States (30) and Hospital Anxiety and Depression Scale (40), which are not specialized for infertility.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated some common emotional responses to infertility and the grief process in infertile women, such as surprise, denial, anger, guilt, depression, grief, and resolution (3)(4)(5)(6). On the other hand, psychoneuroimmunological research has shown that psychological factors can affect immune responses (7)(8)(9)(10)(11)(12). For example, natural killer (NK) cell activity is proposed as a principal factor in the immunoendocrine network in early pregnancy (13)(14)(15).…”

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confidence: 99%

Trial development of the Cognitive Appraisal Scale for Infertility (CASI) (version 1)

Saito

Matsuo

2009

Fertility and Sterility

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“…Our first report 19 clarified the relationship between a general psychological tendency and the immune response in CHD patients. This study focuses on anger and related emotional states, and investigated the relationship between psychological factors and the immune response in the development of CHD.…”

Section: Introductionmentioning

confidence: 88%

Relationship between natural killer activity and anger expression in patients with coronary heart disease

et al. 2003

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Recently, the contribution of the immune system in the development and progression of arteriosclerosis has been suggested. Moreover, psychological stress has also been reported to affect the immune response. Thus, psychological factors are considered to influence the immune response, and an excessive immune response promotes the progression of arteriosclerosis, resulting in the development of coronary heart disease (CHD). In this study, the relationship between the immune response and psychological factors was investigated in CHD patients (n = 74) and normal controls (n = 64). Natural killer (NK) activity was significantly higher in the CHD group than the normal control (CHD vs normal: 8151.39 vs 6653.06, P < 0.05), and was significantly elevated by the suppression of anger and negative emotions (P < 0.05). These results indicate that the characteristic process of psychological response in CHD patients is related to an overresponse of NK activity. We speculate that this linkage significantly influences the development of CHD.

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Immune Function and Psychological Factors in Patients With Coronary Heart Disease (I)

Cited by 16 publications

References 25 publications

Psychologic and sexual dysfunction in primary and secondary infertile male patients

Psychologic and sexual dysfunction in primary and secondary infertile male patients

Trial development of the Cognitive Appraisal Scale for Infertility (CASI) (version 1)

Relationship between natural killer activity and anger expression in patients with coronary heart disease

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