Inhibition of exocrine pancreatic secretion by glucagon and <scp>D</scp>-glucose given intravenously

Nakajima, Sumio; Magee, D. F.

doi:10.1139/y70-049

Cited by 58 publications

(19 citation statements)

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“…TOKUTAKE et al (1976) suggested that inhibition of amino acids on pancreatic exocrine secretion in dogs may be attributed to the direct action of plasma glucagon increased by amino acids administration. The administration of glucagon in vivo causes a short-term inhibition of pancreatic secretion, and in vitro can act directly on the secretion (NAKAJIMA and MAGEE, 1970;MANABE and STEER, 1979;SINGH, 1980). In the present experiment, the inhibitory response induced by amino acids could not be repeated by using exogenous glucagon and insulin.…”

Section: Discussionmentioning

confidence: 61%

Inhibitory influence of amino acids on Secretagogues induced exocrine secretion in isolated perfused rat pancreas.

1984

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Section: Discussionmentioning

confidence: 61%

Inhibitory influence of amino acids on Secretagogues induced exocrine secretion in isolated perfused rat pancreas.

1984

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“…As the zymogen granules and pancreatic secretions contain enzymes in the same proportions (Greene, Hirs &, Palade, 1963), any change in the proportional quantities of the different enzymes secreted within a 12 h period is likely to be due to changes in the rate of enzyme synthesis. Nakajima & Magee (1970) have found that intravenous infusions of glucagon or glucose caused a preferential inhibition of secretion, in the order: amylase < lipase < protease. I n the present experiment the stimulus for the increased synthesis of amylase during 5-12 h after a meal is not clear.…”

Section: Discussionmentioning

confidence: 99%

Concurrent studies of the flow of digesta in the duodenum and of exocrine pancreatic secretion of calves

Ternouth¹,

Roy²,

Thompson³

et al. 1975

Br J Nutr

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I. The flow of digesta through the duodenum and the concurrent secretion of the pancreas were studied in four Friesian calves given four milk-substitute diets. The diets were: reconstituted, 'mildly' pre-heated, spray-dried skim-milk powder with (SKF) or without (SK) margarine fat or with 5 0 yo of the skim-milk powder in diet S K F replaced by soya-bean flour (ASKF) or fish-protein concentrate (BSKF), together with dried whey. The diets were given ad lib. twice daily from 13 to 37 d of age, each diet being given for 6 consecutive days. Collections of duodenal digesta and pancreatic secretions, from cannulas, were made for 12 h after feeding the 6th and 12th meals ('experimental' meals) for each diet.2. The diets fed as 'experimental' meals contained polyethylene glycol (PEG) as a fluid (whey) marker and goat's milk containing [*H]lysine as a marker for total protein; 8-carotene was added as a lipid marker to the three diets containing margarine fat.3. Over the 12 h postprandial period, the patterns of duodenal digesta flow and secretion of pancreatic fluid did not differ markedly between the four diets. The abomasal outflow of both nitrogen and lipid in a 12 h postprandial period was related to their intakes from the 'penultimate' (5th and 11th) meals for diets S K F and SK but to their intakes at the 'experimental meals' for diets ASKF and BSKF. Secretion of pancreatic enzyme activity was highest during the 1st hour after feeding but the main outflow from the abomasum of total N and lipid occurred 5-10 h after feeding.4. The time required for all the whey marker (PEG) to pass through the duodenum was similar for diets SKF and SK, but only 53 and 42 % respectively of the ingested protein marker passed through the duodenum in the 12 h after feeding. More acid appeared to be secreted by the abomasum when diet SK was given; also less undigested protein passed out of the abomasum after giving this diet. It is concluded that the physical absence of fat globules in the abomasal clot increases the degree of proteolysis. 5. The secretions of pancreatic fluid and pancreatic enzyme activity were all markedly lower for diet SK than for diet SKF.6. With diets containing non-milk proteins (ASKF and BSKF), abomasal proteolysis was less efficient and the ingested protein passed out of the abomasum more rapidly than for diet SKF. There was no difference in the rate of abomasal outflow of the whey fluids between diets SKF, ASKF and BSKF.7. In comparison with diet SKF, diets ASKF and BSKF tended to induce less pancreatic enzyme secretion over a 12 h postprandial period, with the exception of lipase.8. There appeared to be no direct relationship between the quantities of any of the pancreatic enzymes secreted during a postprandial period and either the concurrent flow of duodenal digesta or the total quantities of dietary constituents passing through the duodenum. J. H. TERNOUTH AND OTHERS I975Ternouth, Roy & Siddons (1974) showed that the composition of milk-substitute diets affected the secretion of pancreatic enzymes by calv...

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“…A total pancreatic fistula was prepared as described by Nakajima & Magee (1970). Pancreatic juice drops were counted by a photoelectric drop counter.…”

Section: Anaesthetized Dogsmentioning

confidence: 99%

Evidence of Cholecystokinin Release by Bombesin in the Dog

Erspamer¹,

Improta²,

Melchiorri³

et al. 1974

British J Pharmacology

124

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1The intravenous infusion of bombesin elicited in the dog a contraction of the gall bladder with decreased opening pressure of the choledocho-duodenal junction and stimulation of pancreatic secretion. 2 The pancreatic juice -produced under the influence of bombesin was poor in bicarbonate and rich in protein. Threshold doses of the peptide were of the order of 0.25 ,ug kg-' h-1 and maximum protein output was obtained with 1 pg kg'1 h-1. The pancreatic protein response to bombesin was very similar, in its onset and duration, to that elicited by intraduodenal infusion of L-tryptophan. Infusions of bombesin repeated at short intervals produced tachyphylaxis. 3 Antrectomy did not affect the stimulant action of bombesin on the pancreas. Atropine however, reduced the pancreatic protein response to bombesin. 4 It is suggested that bombesin acts on the gall bladder and the exocrine pancreas through release of cholecystokinin from the duodenal mucosa. No release of secretin could be demonstrated. It is likely that the releasing activity of bombesin is limited, in the field of gastrointestinal peptides, to those belonging to the gastrin-cholecystokinin family..

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Inhibition of exocrine pancreatic secretion by glucagon and D-glucose given intravenously

Cited by 58 publications

References 0 publications

Inhibitory influence of amino acids on Secretagogues induced exocrine secretion in isolated perfused rat pancreas.

Inhibitory influence of amino acids on Secretagogues induced exocrine secretion in isolated perfused rat pancreas.

Concurrent studies of the flow of digesta in the duodenum and of exocrine pancreatic secretion of calves

Evidence of Cholecystokinin Release by Bombesin in the Dog

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