Inhibition of Dopamine Synthesis in Chronic Schizophrenia

Effects of Catecholamine Depletion on Alertness and Mood in Rested and Sleep Deprived Normal Volunteers

“…1968; Jonsson et a1. 1971;Ahlenius et al 1973; 0893-133X/93/$0 .00 Pozuelo 1976;Nasrallah et al 1977}. In addition, it has been noted that discontinuation of AMPT treatment is associated with insomnia and decreased total sleep (Bunney et al 1971(Bunney et al , 1977.…”

The effect of metyrosine on oxidative gastric damage induced by ischemia/reperfusion in rats. Biochemical and histopathological evaluation

“…Therefore, research on the treatment of gastric I/R injury is ongoing. Metyrosine, the protective effect of which against gastric I/R injury we will try in this study, is an inhibitor of the tyrosine enzyme that participates in the synthesis of catecholamine 10 . There are studies reporting the antioxidant activity of metyrosine 11 .…”

The Dopamine Hypothesis: An Overview of Studies With Schizophrenic Patients

“…Carlsson's group reported that AMPT treatment allowed a 60-to 79-percent mean reduction in the neuroleptic dose required to control psychotic symptoms in eight chronic schizophrenics (Carlsson et al 1972b(Carlsson et al , 1973Walinder et al 1976). This finding was replicated by Magelund, Gerlach, and Casey (1979), but not by Nasrallah et al (1977) and Gillin et al (1979). Magelund, Gerlach, andCasey (1979) studied 12 chronic schizophrenics whose psychotic symptoms had been exacerbated by a 67-percent mean reduction in their neuroleptic dosage.…”