Effects of Catecholamine Depletion on Alertness and Mood in Rested and Sleep Deprived Normal Volunteers

McCann, Una D.; Penetar, David M.; Shaham, Yavin; Thorne, David R.; Sing, Helen C.; Thomas, Maria; Gillin, J. Christian; Belenky, Gregory

doi:10.1038/npp.1993.34

Cited by 37 publications

(27 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The significant decreases in happiness and increases in tiredness and sleepiness VAS scores on AMPT in our study have also been observed by others in healthy subjects (McCann et al 1993;Laruelle et al 1997). The fact that decrease in happiness was highly and significantly correlated to MHPG decrease but not HVA decrease suggests a larger role for NE depletion than for DA depletion.…”

Section: Clinical Effects Of Amptsupporting

confidence: 90%

“…We, therefore, monitored our subjects regularly for possible extrapyramidal symptoms. Since AMPT was reported to affect subjective feelings in healthy subjects with significant decreases in happiness and increases in sleepiness and restlessness (McCann et al 1993;Laruelle et al 1997), subjects reported subjective feelings both in a continuous visual analog and in an ordinal scale fashion.…”

mentioning

confidence: 99%

See 1 more Smart Citation

A Simple Method to Measure Baseline Occupancy of Neostriatal Dopamine D2 Receptors by Dopamine In Vivo in Healthy Subjects

Verhoeff

Kapur

Hussey

et al. 2001

Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

Section: Clinical Effects Of Amptsupporting

confidence: 90%

mentioning

confidence: 99%

A Simple Method to Measure Baseline Occupancy of Neostriatal Dopamine D2 Receptors by Dopamine In Vivo in Healthy Subjects

Verhoeff

Kapur

Hussey

et al. 2001

Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

“…AMPT induced negative mood when it was combined with 40.5 h sleep deprivation. 99 98 which could persist for 12 h after discontinuation of AMPT. Administration of L-dopa reversed the AMPTinduced effects on sleep, alertness and calmness, but not on anger.…”

Section: Acute Tryptophan Depletionmentioning

confidence: 99%

Monoamine depletion in psychiatric and healthy populations: review

2003

View full text Add to dashboard Cite

A number of techniques temporarily lower the functioning of monoamines: acute tryptophan depletion (ATD), alpha-methyl-para-tyrosine (AMPT) and acute phenylalanine/tyrosine depletion (APTD). This paper reviews the results of monoamine depletion studies in humans for the period 1966 until December 2002. The evidence suggests that all three interventions are specific, in terms of their short-term effects on one or two neurotransmitter systems, rather than on brain protein metabolism in general. The AMPT procedure is somewhat less specific, affecting both the dopamine and norepinephrine systems. The behavioral effects of ATD and AMPT are remarkably similar. Neither procedure has an immediate effect on the symptoms of depressed patients; however, both induce transient depressive symptoms in some remitted depressed patients. The magnitude of the effects, response rate and quality of response are also comparable. APTD has not been studied in recovered major depressive patients. Despite the similarities, the effects are distinctive in that ATD affects a subgroup of recently remitted patients treated with serotonergic medications, whereas AMPT affects recently remitted patients treated with noradrenergic medications. The evidence also suggests that ATD and APTD affect different cognitive functions, in particular different memory systems. Few studies investigated cognitive effects of the procedures in patients. Patients who are in remission for longer may also be vulnerable to ATD and AMPT, but the relationship with prior treatment is much weaker. For these patients, individual vulnerability markers are the more important determinants of depressive response, making these techniques potentially useful models of vulnerability to depression. Molecular Psychiatry (2003) 8, 951-973.

show abstract

“…In addition, strong circadian oscillations are observed throughout the entire TSD period. Diverse studies have found these same results (Angus et al, 1985;Brendel et al, 1990;Dinges et al, 1997;McCann et al, 1992McCann et al, , 1993Mikulincer et al, 1989;Wilhelm, Wilhelm, Ludtke, Streicher, & Adler, 1998). An increase in sleepiness, such as we found, is common among normal subjects following sleep deprivation, as well as among depressive subjects, while not being related to the sleep-deprivation antidepressant effect.…”

Section: The Effect Of Sleep Deprivationmentioning

confidence: 71%

“…Taking into account that the magnitude of the mood change is less in normal subjects than in depressive subjects, a paradigm with a greater number of hours of TSD may be necessary for a positive result in the modulator effect. For example, in the study by McCann et al (1993) in which normal subjects were deprived for 40.5 h and treated with ␣-methyl-para-tirosine (AMPT), increased depression, anger, confusion, tension, and anxiety, as well as decreased calmness and happiness, were reported. Interestingly enough, treatment with sleep deprivation or AMPT alone led to only mild and inconsistent changes in mood.…”

Section: The Effect Of Sleep Deprivationmentioning

confidence: 99%

The role of activation in the effect of total sleep deprivation on depressed mood

2003

View full text Add to dashboard Cite

The present investigation analyzes if the effect of Total Sleep Deprivation (TSD) on depressive mood in normal subjects is related to participants' activation levels. Reaction time (RT), subjective sleepiness, and depressive mood were assessed among 48 normal subjects who were subjected to 60 h of TSD. Subjects were divided into groups based on his/her depressive mood changes following TSD: subjects with worse response (n ϭ 11), subjects with better response (n ϭ 12), and intermediate group (n ϭ 25). We sought to determine if RT and subjective sleepiness were related systematically to depressive mood changes following TSD. TSD produces a general reduction in activation (i.e., a monotonic increase in RT and subjective sleepiness) modulated by circadian oscillations. Baseline activation (RT) was confirmed partially as a predictor of participants' response to TSD. Subjects with high levels of activation (lower RTs at the baseline) experienced a better response (greater reductions in depressive mood) following TSD. There was no relationship between pre-treatment subjective sleepiness levels and the TSD effect on depressive mood. The results partially support the role of the activation level as a differential moderator of TSD effects on depressive mood in normal subjects.

show abstract

Effects of Catecholamine Depletion on Alertness and Mood in Rested and Sleep Deprived Normal Volunteers

Abstract: Alpha·methyl-para-tyrosine (AMPT), a tyrosine kydroxylase inhibitor, was used to evaluate the ylrysiologic role of central nervous system catecholamines

Cited by 37 publications

References 22 publications

A Simple Method to Measure Baseline Occupancy of Neostriatal Dopamine D2 Receptors by Dopamine In Vivo in Healthy Subjects

A Simple Method to Measure Baseline Occupancy of Neostriatal Dopamine D2 Receptors by Dopamine In Vivo in Healthy Subjects

Monoamine depletion in psychiatric and healthy populations: review

The role of activation in the effect of total sleep deprivation on depressed mood

Contact Info

Product

Resources

About