2018
DOI: 10.1590/s0102-865020180030000008 View full text |Buy / Rent full text
Has erratum 2019
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Abstract: Metyrosine prevented the I/R induced oxidative stress in the gastric tissue. Metyrosine may be beneficial for gastric I/R injury.

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“…In the previous study, I/R was found to cause pathological damage like necrosis, hemorrhage, edema, leukocyte infiltration and dilated congested blood vessels in the gastric mucosa [31]. The disappearance of pathological findings in the taxifolin group may be due to its antioxidant activity.…”
Section: Discussionmentioning
“…The disappearance of pathological findings in the taxifolin group may be due to its antioxidant activity. Antioxidant activity has been shown to be important in reducing I/R damage [31,32].…”
Section: Discussionmentioning
“…Our results showed that I/R procedure significantly increased MDA level in gastric tissue compared to SHAM and taxifolin group. Our previous experimental study also presented that I/R procedure elevated MDA level in animal gastric tissue 4 . As it is known, MDA is last molecule of lipid peroxidation (LPO), also a good marker to evaluate oxidative tissue damage 21 .…”
Section: Discussionmentioning
“…One of the product of oxidative DNA damage is 8 hydroxyguanine (8-OHGua) and is used as an important parameter in determining oxidative stress 3 . In recent studies, the roles of increase in MDA production and decrease in total glutathione (tGSH) production have been shown in the pathogenesis of gastric ischemia-reperfusion (I/R) injury 4 . Polat et al 5 .…”
Section: Introductionmentioning