“…Luteoskyrin is also toxic to Chang's liver cells, to HeLa cells, and to protozoa such as Paramecium caudatum (Kawamoto et al, 1964) and Tetrahymena pyriformis (Ueno and Saheki, 1968; Mouton and Fromageot, 1971). This pigment induces chromosome aberrations in cultures of Ehrlich ascites (Schachtschabel et al, 1969), and chromosome breakage in cultured human leukocytes (Keutel and Mockel, 1969). Moreover, Ls and Rg have been proved to inhibit both in vitro and in vivo, essential biological functions such as replication, transcription, and DNA repair (Umeda et al, 1963;Umeda, 1964;Schachtschabel et al, 1969; Mouton and Fromageot, 1971;Sentenac et al, 1967; Ruet et al, 1973).…”