Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice

Pan, Min‐Hsiung; Li, Shiming; Lai, Ching-Shu; Miyauchi, Yoshimasa; Suzawa, Michiko; Ho, Chi‐Tang

doi:10.1016/j.fshw.2012.09.001

Cited by 34 publications

(21 citation statements)

References 20 publications

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“…Moreover, the citrus secondary metabolites such as flavonoids, hesperetin, limonoids, nobiletin, naringenin and coumarins were studied for anticancer activity, which are associated with a reduced risk of cancer, including gastric cancer, breast cancer, colon cancer, lung tumorigenesis, colonic tumorigenesis, hepatocarcinogenesis, and hematopoietic malignancies, etc. [21][22][23][24][25][26][27][28][29][30][31][32][33][34].…”

Section: In Vivo Anti-tumor Activitymentioning

confidence: 99%

“…Medicinal plants are playing an important role as a source of effective anticancer agents and it is significant that 60% of currently used anticancer agents are derived from natural sources including plants [20]. Plant-derived products have been reported to exhibit potent antitumor activity against several rodent and human cancer cell lines [21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Thus, cancer patients who already got crippled with this disease, and who are further burdened by drug-induced toxic side effects, have now turned to seek help from the complementary and alternative medicine hoping for a better cure [35].…”

Section: Introductionmentioning

confidence: 99%

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Screening of Antibacterial, Thrombolytic, Membrane Stabilizing, Anti-inflammatory and Antitumor Activity of <i>Citrus assamensis</i> Leaf Extracts

Shahriar

Bhuiyan²,

Rana³

2018

J. Sci. Res.

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The methanol, ethanol and chlorofom leaf extracts of Satkara, Citrus assamensis (family: Rutaceae), were subjected to in vitro anti-bacterial, thrombolytic, membrane stabilizing and in vivo anti-inflammatory and antitumor activity tests. The chloroform extract of C. assamensis showed the most important spectrum of activity against Bacillus subtilis, Bacillus cereus, Sarcina lutea among 6 gram positive and against 11 gram negative bacteria at the concentration of 1000 μg/disc, while the range of zones of inhibition were within 7-16 mm. Among the tested three extracts CHCl 3 extract showed potent thrombolytic activity and hypotonic solution induced haemolytic activity where the percentages of inhibition were found to be 35% and 55% respectively. All the extracts established significant (p<0.05) anti-inflammatory effect by regulating biphasic inflammatory process induced by carrageenan. The leaf extract dose-dependently and significantly decreases the number of EAC cell count and inhibition of cell growth in comparison to the EAC control and standard. The results obtained in the present study indicate that, C. assamensis leaf can be a potential source of anti-bacterial, thrombolytic, membrane stabilizing, anti-inflammatory and antitumor agents.

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Section: In Vivo Anti-tumor Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Screening of Antibacterial, Thrombolytic, Membrane Stabilizing, Anti-inflammatory and Antitumor Activity of <i>Citrus assamensis</i> Leaf Extracts

Shahriar

Bhuiyan²,

Rana³

2018

J. Sci. Res.

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“…Moreover, the citrus secondary metabolites were studied for anticancer activity, for example, flavonoids on skin cancer,[68] hesperetin on colon cancer,[69] limonoids on colon cancer,[70] nobiletin on gastric cancer,[71] naringenin on prostate cancer,[72] gastric cancer,[73] and hepatocarcinoma. [26]…”

Section: Introductionmentioning

confidence: 99%

Anticancer activity of key lime, Citrus aurantifolia

Narang¹,

Jiraungkoorskul²

2016

Phcog Rev

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Citrus aurantifolia (family: Rutaceae) is mainly used in daily consumption, in many cultural cuisines, and in juice production. It is widely used because of its antibacterial, anticancer, antidiabetic, antifungal, anti-hypertensive, anti-inflammation, anti-lipidemia, and antioxidant properties; moreover, it can protect heart, liver, bone, and prevent urinary diseases. Its secondary metabolites are alkaloids, carotenoids, coumarins, essential oils, flavonoids, phenolic acids, and triterpenoids. The other important constituents are apigenin, hesperetin, kaempferol, limonoids, quercetin, naringenin, nobiletin, and rutin, all of these contribute to its remedial properties. The scientific searching platforms were used for publications from 1990 to present. The abstracts and titles were screened, and the full-text articles were selected. The present review is up-to-date of the phytochemical property of C. aurantifolia to provide a reference for further study.

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“…The unusual characteristic and feature of citrus peel flavonoids is its high concentration of a diverse assortment of flavonoids. One of the known flavonoids is nobiletin, which is a citrus polymethoxyflavones is known to be effective in combating against skin [32,33], colon [34,35], prostate [36], lung [37] including liver cancer [38,39]. The mechanisms include inhibition of inflammation, angiogenesis and induction of apoptosis [30,31].…”

mentioning

confidence: 99%

“…In addition, nobiletin is biochemically stable hence can be produced in bulk quantity for more studies both in vivo and in vitro for stronger activities [32]. Pan et al [33] studied in vivo antitumor of the citrus peel gold lotion product efficiency. The potential mechanism was elucidated involving animal induced with 7,12-dimethylbenz-[a]anthracene/12-O-tetradecanoylphorbol-13-aetate (DMBA/ TPA) for two-stage skin carcinogenesis model.…”

mentioning

confidence: 99%

Citrus Peel as a Source of Beneficial Phytochemical and Pharmacological Potential

Abidin¹,

Bakar²,

Anuar³

et al. 2019

Asian J. Chem.

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Citrus plant is native to tropical Asia. Despite that it is also found in all tropical and subtropical country. The worldwide annual production of citrus fruits is 105 million metric tons between 2000 and 2004 [1] and has been increasing steadily throughout 2000s reaching over 124 million tonnes by 2016 [2]. Citrus fruits belong to the family Rutaceae of the genus Citrus. Which includes fruits such as tangerine, orange, lemon, lime and grapefruit. Citrus fruits are well-known as a source of beneficial nutrients as well as phenolic compounds which are for human health. In major citrus producing countries such as Brazil and the United States, the percentage of fruits being utilized into juices reaches 96 % while the average percentage is 34 % [1]. Based on the average yield of juices, peel of citrus covers a big part of surplus [1,3-5]. Owing to a large amount of waste produced, fermentation of the waste is affecting the environment. Citrus by-products which eventually discarded

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Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice

Cited by 34 publications

References 20 publications

Screening of Antibacterial, Thrombolytic, Membrane Stabilizing, Anti-inflammatory and Antitumor Activity of <i>Citrus assamensis</i> Leaf Extracts

Screening of Antibacterial, Thrombolytic, Membrane Stabilizing, Anti-inflammatory and Antitumor Activity of <i>Citrus assamensis</i> Leaf Extracts

Anticancer activity of key lime, Citrus aurantifolia

Citrus Peel as a Source of Beneficial Phytochemical and Pharmacological Potential

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