Inhibition by lithium of the nitrergic relaxation of rat anococcygeus muscle

Karimollah, Ali Reza; Ghasemi, Mehdi; Ghahremani, Mohammad Hossein; Dehpour, Ahmad Reza

doi:10.1016/j.niox.2008.08.007

Cited by 8 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, our previous data showed that the NANC relaxation of rat isolated corpus cavernosum was decreased in the presence of different concentrations of lithium. The NANC relaxation in other tissue strips including gastric fundus [29] and anococcygeus muscle [30] were also reported to be attenuated in the presence of lithium in vitro, which is in contrast with our present data. These differences in results could be explained by the fact that in all of our previous studies, we used different isolated tissue strips from rats, but our study was performed on the guinea pig isolated cavernosal tissue strips, suggesting that these discrepancies in results might be because of the differences in the animal species used.…”

Section: Discussioncontrasting

confidence: 99%

“…Our data showed that the competitive nonspecific NO synthase inhibitor l ‐NAME significantly attenuated the endothelium‐mediated relaxation of the guinea pig cavernosal smooth muscle in a concentration‐dependent manner, suggesting the acetylcholine‐induced relaxation of the cavernosal strips is mediated via NO. The SNP (a NO donor)‐induced relaxation of guinea pig corpus cavernosum, which activate cGMP synthesis directly, was not affected by lithium, indicating that cavernosal smooth muscle responsiveness to NO is not affected by lithium administration which is similar to our previous studies [24,29,30]. In this regard, the inhibitory effect of lithium on endothelium‐mediated relaxation of guinea pig corpus cavernosum might be a result of a decreased constitutive NO production in cavernosal endothelium or a decreased NO availability.…”

Section: Discussionsupporting

confidence: 86%

“…This is in line with the fact that most patients should receive the drug for a long period of time. Accordingly, in our previous study, we also demonstrated that chronic lithium treatment impaired both NANC relaxation and endothelium‐mediated relaxation in rat corpus cavernosum [25] and also NANC relaxation in rat anococcygeus muscle strips [30] through involvement of nitrergic system. Therefore, it seems that one of the mechanisms by which lithium causes erectile dysfunction is its direct effect on the corpus cavernosum relaxation as an end organ for erectile function.…”

Section: Discussionmentioning

confidence: 85%

See 2 more Smart Citations

Lithium decreased endothelium‐mediated, but not nonadrenergic noncholinergic, relaxation of guinea pig corpus cavernosum in vitro: a role for nitrergic system

Ghasemi

Farrokhi-Khajeh-Pasha

Ostovaneh

et al. 2011

Fundamemntal Clinical Pharma

Self Cite

View full text Add to dashboard Cite

Lithium causes erectile dysfunction in patients but its mechanism is yet unknown. The aim of our study was to verify the effect of acute lithium administration on the nonadrenergic noncholinergic (NANC)- and endothelium-mediated relaxation of guinea pig isolated corpus cavernosum. Although lithium (0.5, 1, and 5mm) had no effect on the neurogenic relaxations, it significantly (P<0.001) attenuated the relaxant responses to acetylcholine in a concentration-dependent manner. Combination of low concentration of lithium (0.5mm) with either 0.1 or 1μm l-NAME significantly (P<0.001) reduced the endothelium-mediated relaxation. Although the Nitric oxide (NO) precursor l-arginine at 1mm did not alter the relaxant responses to acetylcholine in control strips, it improved the inhibition by lithium (1mm) of relaxant responses to acetylcholine. Sodium nitroprusside (SNP; 10nm-1mm) produced similar concentration-dependent relaxations in both groups. Our experiments indicated that lithium can result in impairment of the NO-mediated endothelium-dependent but not NANC relaxation of guinea pig corpus cavernosum.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 85%

See 1 more Smart Citation

Lithium decreased endothelium‐mediated, but not nonadrenergic noncholinergic, relaxation of guinea pig corpus cavernosum in vitro: a role for nitrergic system

Ghasemi

Farrokhi-Khajeh-Pasha

Ostovaneh

et al. 2011

Fundamemntal Clinical Pharma

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, it was suggested that both endothelium- and NANC-mediated NO is involved in the inhibitory effects of lithium on the rat cavernosal smooth muscle relaxation, and thereby penile erection [ 57 ] ( Figure 2 ). The NO-mediated NANC relaxation in other rat tissues such as the gastric fundus [ 84 ] and anococcygeus muscle [ 85 ] were also found to be attenuated with acute lithium treatment in vitro. Such acute effects of lithium were also evaluated in guinea pig isolated corpus cavernosum in vitro [ 59 ].…”

Section: Lithium and Sexual Dysfunctionmentioning

confidence: 99%

Lithium and Erectile Dysfunction: An Overview

Sheibani

Ghasemi

Dehpour

2022

Cells

Self Cite

View full text Add to dashboard Cite

Lithium has been a mainstay of therapy for patients with bipolar disorders for several decades. However, it may exert a variety of adverse effects that can affect patients’ compliance. Sexual and erectile dysfunction has been reported in several studies by patients who take lithium as monotherapy or combined with other psychotherapeutic agents. The exact mechanisms underlying such side effects of lithium are not completely understood. It seems that both central and peripheral mechanisms are involved in the lithium-related sexual dysfunction. Here, we had an overview of the epidemiology of lithium-related sexual and erectile dysfunction in previous clinical studies as well as possible pathologic pathways that could be involved in this adverse effect of lithium based on the previous preclinical studies. Understanding such mechanisms could potentially open a new avenue for therapies that can overcome lithium-related sexual dysfunction and improve patients’ adherence to the medication intake.

show abstract

“…Nitric oxide system is crucial for flap survival by mediating vascular endothelial relaxation [1]. In this article, we focused on lithium, which has known interactions with NO [2,3].…”

Section: Introductionmentioning

confidence: 99%