Lithium decreased endothelium‐mediated, but not nonadrenergic noncholinergic, relaxation of guinea pig corpus cavernosum in vitro: a role for nitrergic system

Ghasemi, Mehdi; Farrokhi-Khajeh-Pasha, Yasin; Ostovaneh, Mohammad Reza; Dehpour, Ahmad Reza

doi:10.1111/j.1472-8206.2010.00825.x

Cited by 6 publications

(11 citation statements)

References 39 publications

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“…Lithium, valproate, carbamazepine (CBZ), and second-generation antipsychotics (e.g., olanzapine) are effective for the treatment of acute manic episodes [1,2]. However, some patients fail to respond adequately to these treatments, and the adverse effects of these drugs might limit their use or reduce adherence to treatment [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

The antimanic‐like effect of phenytoin and carbamazepine on methylphenidate‐induced hyperlocomotion: role of voltage‐gated sodium channels

Tonelli

Pereira

Siba

et al. 2013

Fundamemntal Clinical Pharma

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The objective of this study was to verify whether phenytoin modifies methylphenidate-induced hyperlocomotion, an animal model for screening antimanic-like drugs, and also evaluate the effect of veratrine, a voltage-gated sodium channel opener, pretreatment on the effect of phenytoin in this model. Carbamazepine was used as a positive control. Methylphenidate (5 mg/kg, s.c.) increased open-field locomotion, and phenytoin (5-10 mg/kg, i.p.) and carbamazepine (20 mg/kg, i.p.) blocked this effect. Veratrine (0.4 mg/kg, s.c.) pretreatment reversed the effects of phenytoin (10 mg/kg, i.p.) and carbamazepine (20 mg/kg, i.p.). Phenytoin (1-50 mg/kg, i.p.) and carbamazepine (10-20 mg/kg i.p.) alone did not change spontaneous locomotor activity. These results indicate that voltage-gated sodium channels play an important role in antimanic-like effects of phenytoin and carbamazepine on psychostimulant-induced hyperlocomotion model.

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Section: Introductionmentioning

confidence: 99%

The antimanic‐like effect of phenytoin and carbamazepine on methylphenidate‐induced hyperlocomotion: role of voltage‐gated sodium channels

Tonelli

Pereira

Siba

et al. 2013

Fundamemntal Clinical Pharma

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“…Penile erection occurs as a consequence of cavernosal smooth muscle relaxation, in which NO seems to play a central role . Lithium probably causes erectile dysfunction through impairment of endothelial‐mediated relaxation of the corpus cavernosa . This effect of lithium might be related to its regulatory effect on phosphoinositol‐linked second messengers , as the activity of the phosphoinositol cycle in the endothelium of the corpus cavernosum is a crucial step in NO production .…”

Section: Discussionmentioning

confidence: 99%

“…However, lithium can negatively affect several organs, including the kidneys, thyroid gland, and skin (6,7). Several studies have also suggested a negative effect of lithium on sexual function (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Although the frequency of the sexual side effects of lithium is lower than that of selective serotonin reuptake inhibitors, it is still high enough to warrant further consideration.…”

Section: Objectivesmentioning

confidence: 99%

“…Although the frequency of the sexual side effects of lithium is lower than that of selective serotonin reuptake inhibitors, it is still high enough to warrant further consideration. Several animal studies have shown deteriorating effects of lithium on sexual function (14)(15)(16)(17)(18)(19). Chronic lithium treatment can reverse apomorphine-induced erection in rats (15,16).…”

Section: Objectivesmentioning

confidence: 99%

“…To our knowledge, no published study has addressed the treatment of lithium‐related sexual dysfunction in stable patients with BAD. It has been shown that chronic lithium treatment can cause erectile dysfunction through impairment of the nitric oxide (NO) pathway . Importantly, this effect of lithium seems to be present at concentrations below the therapeutic range of the drug .…”

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confidence: 99%

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Aspirin for treatment of lithium‐associated sexual dysfunction in men: randomized double‐blind placebo‐controlled study

et al. 2013

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Sexual Dysfunction and Mood Stabilizers in Long-Term Stable Patients with Bipolar Disorder

García‐Blanco¹,

García-Portilla

Fuente-Tomás

et al. 2020

The Journal of Sexual Medicine

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Background In addition to factors intrinsic to bipolar disorder (BD), sexual functioning (SF) can be affected by extrinsic causes, such as psychotropic drugs. However, the effect of mood stabilizers on SF and quality of life (QoL) is an underexplored research area. Aim To analyze SF in BD outpatients in euthymia for at least 6 months treated only with mood stabilizers and the association between SF and QoL. Methods A multicenter cross-sectional study was conducted in 114 BD outpatients treated with (i) lithium alone (L group); (ii) anticonvulsants alone (valproate or lamotrigine; A group); (iii) lithium plus anticonvulsants (L+A group); or (iv) lithium plus benzodiazepines (L+B group). The Changes in Sexual Functioning Questionnaire Short Form (CSFQ-14) was used. Statistical analyses were performed to compare CSFQ-14 scores among the pharmacological groups. An adaptive lasso was used to identify potential confounding variables, and linear regression models were used to study the association of the CSFQ-14 with QoL. Main Outcome Measures Self-reports on phases of the sexual response cycle (ie, desire, arousal, and orgasm) and QoL were assessed. Results The A group had better total SF scores than the L group and the L+B group. Relative to the A group, the L and L+B groups had worse sexual desire; the L group had worse sexual arousal; and the L+A group and the L+B group had worse sexual orgasm. Regarding sociodemographic factors, being female and older age were associated with worse total SF and all subscale scores. Among all subscales scores, higher sexual arousal scores were associated with better QoL. Clinical Implications Potential modified extrinsic factors such as psychotropic medication that can affect SF can be addressed and adjusted to lessen side effects on SF. Strengths & Limitations Sample of patients with euthymic BD in treatment with mood stabilizers and no antipsychotics or antidepressants, substance use as an exclusion criterion, and use of a validated, gender-specific scale to evaluate SF. Major limitations were cross-sectional design, sample size, and lack of information about stability of relationship with partner. Conclusions Lithium in monotherapy or in combination with benzodiazepines is related to worse total SF and worse sexual desire than anticonvulsants in monotherapy. While the addition of benzodiazepines or anticonvulsants to lithium negatively affects sexual orgasm, sexual arousal (which plays a significant role in QoL) improves when benzodiazepines are added to lithium. Anticonvulsants in monotherapy have the least negative effects on SF in patients with BD.

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Lithium decreased endothelium‐mediated, but not nonadrenergic noncholinergic, relaxation of guinea pig corpus cavernosum in vitro: a role for nitrergic system

Cited by 6 publications

References 39 publications

The antimanic‐like effect of phenytoin and carbamazepine on methylphenidate‐induced hyperlocomotion: role of voltage‐gated sodium channels

The antimanic‐like effect of phenytoin and carbamazepine on methylphenidate‐induced hyperlocomotion: role of voltage‐gated sodium channels

Aspirin for treatment of lithium‐associated sexual dysfunction in men: randomized double‐blind placebo‐controlled study

Sexual Dysfunction and Mood Stabilizers in Long-Term Stable Patients with Bipolar Disorder

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