Chronic Lithium Impairs Skin Tolerance to Ischemia in Random-Pattern Skin Flap of Rats

Nezami, Behtash Ghazi; Rahimpour, Sina; Sadeghi, Mahsa; Sianati, Setareh; Anaraki, Dina Kalbasi; Ebrahimi, Farzad; Ghasemi, Mehdi; Dehpour, Ahmad Reza

doi:10.1016/j.jss.2010.03.048

Cited by 7 publications

(1 citation statement)

References 33 publications

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“…Many chemicals, such as sympatholytics, vasodilators, calcium channel blockers, prostaglandin inhibitors, glucocorticoids and free radical scavengers are known to improve flap viability (de Godoy et al, 2010; Gözü et al, 2010; Livaoğlu et al, 2009; Manchio et al, 2009; Nezami et al, 2009; 2010). However, even with these chemical treatments, flap necrosis may still occur.…”

Section: Introductionmentioning

confidence: 99%

Effects of natural and recombinant hirudin on superoxide dismutase, malondialdehyde and endothelin levels in a random pattern skin flap model

Yingxin

Yin

et al. 2011

J Hand Surg Eur Vol

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We have assessed the anti-inflammatory, anti-oxidative and anti-coagulant effects of locally applied natural and recombinant hirudin in a random skin flap rat model. Thirty Wistar rats with venous congested skin flaps were randomly divided into two treatment groups and a control group to receive subcutaneous injections of natural hirudin (6 U), recombinant hirudin (6 U) or physiological saline, respectively. Superoxide dismutase, malondialdehyde and endothelin levels as well as flap survival rates of the skin flaps were measured after surgery. Compared to the control group, the treatment groups had significant higher superoxide dismutase levels and lower malondialdehyde and endothelin levels in the skin flaps. The surviving areas of the flaps were larger in the treatment groups than the control group. Our results demonstrated that hirudin could improve skin flap survival through its anti-inflammatory, anti-oxidative and anti-coagulant activities.

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