Inheritance of varicoceles

Raman, Jay D.; Walmsley, Konstantin; Goldstein, Marc

doi:10.1016/j.urology.2004.12.057

Cited by 60 publications

(36 citation statements)

References 16 publications

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“…The incidence of varicocele in the patients whose first-degree relatives (such as a father or brother) had varicocele was found to be 3 -4 times higher than the normal population [20] [21]. In our study, 24 (14.4%) of the patients had a positive family history of varicocele.…”

Section: Discussionmentioning

confidence: 46%

Adolescent Varicocele

Çimen¹

2018

OJU

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Introduction: Adolescent varicocele is still a controversial issue in pediatric urology. In this study, we aimed to evaluate adolescent patients with varicocele, who were operated in our clinic, in the light of literature. Materials and Methods: The data of adolescent patients who underwent varicocelectomy between January 2012 and January 2018 in the Urology Clinic of Malatya Training and Research Hospital were examined retrospectively. The age and admission complaint of the patients, the localization of varicocele, the varicocele grade determined by color Doppler ultrasound (US), the presence of testicular atrophy, the height, weight, body mass index of the patients as well as their relationship with each other were evaluated. Results: The mean age of the patients is 14.74 years (10 -17 years). Of the patients, 153 (92.2%) had a left-sided varicocele and 13 (7.8%) had a right-sided varicocele. When admission complaints of the patients were examined, 31 (18.6%) had scrotal pain, 53 (32.2%) had scrotal swelling, 21 (12.6%) had skin bruising, 40 (24%) had dilated veins recognized by the family, and 21 (12.6%) had more than one complaint. When the relationship between varicocele grade and BMI was examined, 13 (35.1%) of the 37 patients with a grade 2 varicocele were lean, 23 (62.1%) were normal weight, and 1 (2.8%) was obese. 12 (17.7%) of the 68 patients with a grade 3 varicocele were lean, 54 (79.4%) were normal weight, and 2 (2.9%) were overweight. 8 (13.1%) of the 61 (36.7%) with a grade 4 varicocele were lean, 46 (75.5%) were normal weight, and 7 (11.4%) were overweight. Conclusion: Adolescent varicocele is still one of the controversial issues today; the diagnosis should be made with the help of physical examination and radiological tests besides the family's application in boys in this age group in order to prevent possible problems.

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Section: Discussionmentioning

confidence: 46%

Adolescent Varicocele

Çimen¹

2018

OJU

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“…1 In a retrospective review by Raman et al, increased varicocele prevalence was observed in first-degree relatives (particularly brothers) of patients with known varicoceles. 13 Up to 40% of adult men with primary infertility have a varicocele and prevalence rises to 81% in men with secondary infertility. 14 Varicoceles in the pediatric population: Diagnosis, treatment, and outcomes…”

Section: Epidemiologymentioning

confidence: 99%

Varicoceles in the pediatric population: Diagnosis, treatment, and outcomes

Reyes¹,

Locke²,

Afshar³

2017

CUAJ

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Varicocele is commonly encountered in adolescents. There are still many controversies regarding pathophysiology, health effects, clinical significance, and optimum treatment of this condition. This article reviews the current evidence pertaining to children and adolescents with varicocele. This group present a unique and somehow challenging situation, since they are still going through pubertal changes that may confound the effects of the disease and its treatment on the developing testes.

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“…It is identified in 7 and 10-25 % of prepubertal and postpubertal males, respectively [89,90]. Higher prevalence in elderly males and in men with secondary MFI suggests it to be a progressive disease [91,92]. Recent data suggest that varicocele causes infertility by inducing ultrastructural testicular changes and OS, with implications for the seminal antioxidant capacity and sperm chromatin integrity [93][94][95].…”

Section: Varicocelementioning

confidence: 99%

Engaging Practicing Gynecologists in the Management of Infertile Men

Agarwal

Hamada

Esteves³

2014

J Obstet Gynecol India

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In the modern era, contemporary management of male infertility has undergone groundbreaking changes with the introduction of new concepts, advanced testing, and therapeutic interventions. As practicing gynecologists are often the first physicians who encounter an infertile couple, it is essential that these clinicians are continuously updated about the new pearls and pitfalls of male infertility management. Semen analysis is commonly ordered by gynecologists. In 2010, the WHO released new cutoff reference values for the semen parameters adopting novel methodology, which has incited much debate. Reference values have been lowered in comparison with previous standards, with a direct clinical implication in decision-making strategies. Specialized sperm-function tests, such as sperm oxidative stress and sperm chromatin integrity assessments, became clinically available, thus offering an opportunity to better understand sperm dysfunctions concealed during routine semen analysis. Furthermore, the initial counseling of azoospermic men by an andrologically well educated gynecologist may alleviate the misconception and distress surrounding the false belief of sterility, and will clarify the 123 available options of percutaneous and microsurgical spermretrieval techniques and assisted conception outcome. Regarding varicocele, which is commonly seen in infertile males, it is now clear that the best treatment option for infertile men with clinical varicocele is the microsurgical vein ligation. Natural conception is significantly improved after varicocelectomy, and recent data suggest that such treatment optimizes reproductive outcome of couples undergoing ICSI or micro-TESE sperm retrieval. Lastly, new therapeutic interventions, including oral antioxidant therapy and lifestyle modifications, have gained increasing attention, as they aid in alleviating male infertility.

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Inheritance of varicoceles

Cited by 60 publications

References 16 publications

Adolescent Varicocele

Adolescent Varicocele

Varicoceles in the pediatric population: Diagnosis, treatment, and outcomes

Engaging Practicing Gynecologists in the Management of Infertile Men

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