1983
DOI: 10.1016/s0022-3476(83)80679-9
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Inhaled salbutamol (albuterol) vs injected epinephrine in the treatment of acute asthma in children

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Cited by 105 publications
(9 citation statements)
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“…Dos de los fármacos más usados son el salbutamol y el fenoterol. La ruta de administración que se prefiere para los beta-2 agonistas es la vía inhalatoria (5,17,26,27) ya que esta maximiza la cantidad de droga aplicada a la vía aérea y minimiza los efectos colaterales. Una forma de administración adecuada es por medio de un microdosificador inhalatorio (MDI) (8,28) que ha demostrado ser tan o más eficaz que el nebulizador (29) ya que con el MDI se obtiene igual efecto broncodilatador con una menor dosis (28).…”
Section: Discussionunclassified
“…Dos de los fármacos más usados son el salbutamol y el fenoterol. La ruta de administración que se prefiere para los beta-2 agonistas es la vía inhalatoria (5,17,26,27) ya que esta maximiza la cantidad de droga aplicada a la vía aérea y minimiza los efectos colaterales. Una forma de administración adecuada es por medio de un microdosificador inhalatorio (MDI) (8,28) que ha demostrado ser tan o más eficaz que el nebulizador (29) ya que con el MDI se obtiene igual efecto broncodilatador con una menor dosis (28).…”
Section: Discussionunclassified
“…It has been described with epinephrine (adrenaline) and aminophylline (Halmagyi & Cotes 1959), isoprenaline (isoproterenol) and orciprenaline (metaproterenol) [Chapman 1969], and with both intravenous (Ballester et al 1989) and inhaled salbutamol (Harris 1972;Choo-Kang et al 1974;Coupe 1987). Nebulised salbutamol produced highly significant clinical hypoxia in 2 of 20 children requiring emergency treatment for acute asthma attacks [alveolar oxygen pressure (pa02) fall > 10%] (Becker et al 1983) and in a further 9 of 18 children (Pa02 fall >5%) when used in conjunction with intravenous aminophylline (Tal et al 1984). The V /Q ratio is preserved in the acute asthmatic attack by vasoconstriction of arterioles associated with areas of underventilated lung.…”
Section: Discussionmentioning
confidence: 99%
“…No significant differences were found in pulmonary function testing. They did, however, find an increase in adverse effects including nausea and vomiting, headache, tremor, and palpitations [60]. A 1984 study of 46 children comparing the same therapies found a statistically significant difference in the percentage change of peak expiratory flow rate (PEFR), favoring the SABA [61].…”
Section: Parenteral Beta-adrenergicsmentioning
confidence: 99%
“…Adverse side effects are common in the studies evaluating epinephrine [60,61,63]. A 1988 study of 95 patients who received epinephrine for ASA showed no clinically important arrhythmias in the over 40 age group and 2 episodes of accelerated idioventricular rhythm in the younger group.…”
Section: Parenteral Beta-adrenergicsmentioning
confidence: 99%