Inhalation of 30% nitrous oxide impairs people's learning without impairing people's judgments of what will be remembered.

Abstract

Many hypotheses have been proposed to account for the effects of nitrous oxide on memory, with one emerging possibility being that it has a global effect on memory-related functioning. This possibility was explored by examining the effects of nitrous oxide on memory performance and on the accuracy of people's judgments about their memory performance. Participants inhaled 30% nitrous oxide or a placebo gas while items were studied and while judgments were made about the likelihood of recall for each item. Next, all participants inhaled the placebo during paired-associate recall. Although administration of nitrous oxide during study impaired recall, it did not affect the predictive accuracy of the metacognitive judgments. These results provide pharmacological evidence for a distinction between memory and metamemory.

Metacognition, metamemory, and mindreading in high-functioning adults with autism spectrum disorder.

“…This model is supported by neuropsychological (e.g., Janowsky, Shimamura, & Squire, 1989;Shimamura & Squire, 1986) and psycho-pharmacological (e.g., Dunlosky et al, 1998) data, which highlight a dissociation between memory and metamemory. According to Nelson and Narens' model, through metamemory monitoring individuals create a meta-representation of the object-level (Nelson & Narens, 1990).…”

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