2016
DOI: 10.3945/jn.116.231340
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Ingestion of Wheat Protein Increases In Vivo Muscle Protein Synthesis Rates in Healthy Older Men in a Randomized Trial

Abstract: The myofibrillar protein synthetic response to the ingestion of 35 g casein is greater than after an equal amount of wheat protein. Ingesting a larger amount of wheat protein (i.e., 60 g) substantially increases myofibrillar protein synthesis rates in healthy older men. This trial was registered at clinicaltrials.gov as NCT01952639.

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Cited by 154 publications
(211 citation statements)
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References 37 publications
(58 reference statements)
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“…Multiple factors, including the source, per meal dose, daytime pattern and timing (in relation to exercise) of ingested protein, as well as co-ingestion of other nutrients, all modulate the response of MPS to protein intake [30]. Leucine-rich rapidly digested sources, such as whey protein, have been shown to elicit a greater stimulation of MPS during recovery compared with slowly digested proteins of lower leucine composition, such as soy, micellar casein [31], and wheat [32]. Leucine increases MPS by directly activating the mechanistic target of rapamycin complex 1 (mTORC1) through the leucine-binding protein sestrin2 [33].…”
Section: Overview Of Protein Carbohydrates and Fluidsmentioning
confidence: 99%
“…Multiple factors, including the source, per meal dose, daytime pattern and timing (in relation to exercise) of ingested protein, as well as co-ingestion of other nutrients, all modulate the response of MPS to protein intake [30]. Leucine-rich rapidly digested sources, such as whey protein, have been shown to elicit a greater stimulation of MPS during recovery compared with slowly digested proteins of lower leucine composition, such as soy, micellar casein [31], and wheat [32]. Leucine increases MPS by directly activating the mechanistic target of rapamycin complex 1 (mTORC1) through the leucine-binding protein sestrin2 [33].…”
Section: Overview Of Protein Carbohydrates and Fluidsmentioning
confidence: 99%
“…; Gorissen et al . ). However, beyond their protein content, consumption of plant‐based foods is associated with numerous health benefits (Mudryj et al .…”
Section: Nutritionmentioning
confidence: 97%
“…Potential ways to overcome the lower anabolic capacity of plant‐based proteins include the following: ingesting a greater protein dose (Gorissen et al . ), fortifying plant‐based foods with leucine (Murphy et al . ), combining plant‐based proteins with higher quality (and higher leucine) animal‐based sources (Reidy et al .…”
Section: Nutritionmentioning
confidence: 99%
“…kg -1. (WILKINSON et al, 2007;TANG et al, 2009;YANG et al, 2012;GORISSEN et al, 2016). A explicação mais plausível para tal resposta, seria pelo fato que os aminoácidos provenientes de proteínas vegetais são maiormente oxidados (YANG et al, 2012), assim como também, direcionados em maior proporção para os tecidos esplênicos que para os tecidos periféricos (e.g., músculo esquelético) (FOUILLET et al, 2002;BOS et al, 2003).…”
Section: Discussionunclassified
“…Adicionalmente, as fontes vegetais apresentam fibras e fatores antinutricionais (e.g., inibidores de tripsina, fitatos e hemaglutininas) os quais diminuem a digestibilidade de proteínas e a biodisponibilidade de aminoácidos (GILANI; COCKELL; SEPEHR, 2005). Neste sentido, vários estudos têm consistentemente demonstrado um menor potencial anabólico em resposta às fontes proteicas vegetais (e.g., soja ou trigo) vs. animais (e.g., leite ou whey protein), em condições isoproteicas, associadas (WILKINSON et al, 2007;TANG et al, 2009;YANG et al, 2012) ou não (TANG et al, 2009;YANG et al, 2012;GORISSEN et al, 2016) ao treino de força, sugerindo, portanto, que as proteínas animais poderiam ser mais vantajosas em induzir ganhos de massa muscular.…”
Section: Introductionunclassified