Informações toxicológicas de alguns fitoterápicos utilizados no Brasil

Turolla, Monica Silva dos Reis; Nascimento, Elizabeth de Souza

doi:10.1590/s1516-93322006000200015

Cited by 83 publications

(64 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Apesar do baixo índice de efeitos adversos já relatados em estudos anteriores, sabe-se que muitas plantas medicinais apresentam substâncias que podem desencadear reações tóxicas, exigindo um rigoroso controle de qualidade desde o cultivo, coleta, extração de seus constituintes, até a elaboração final do fitoterápico (Turolla & Nascimento, 2006). O conhecimento passado de geração em geração constitui importante fator para a disseminação do uso popular das plantas medicinais, tendo sido a principal fonte de informação utilizada pelos entrevistados em Nova Xavantina (71,5%), os demais disseram que a influência maior para a utilização de plantas foi proveniente de amigos, vizinhos, ou mesmo de livros sobre o assunto.…”

Section: Resultsunclassified

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Silva¹,

Melo²,

Ribeiro³

et al. 2010

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO:O presente trabalho verificou a utilização de plantas medicinais encontradas no Cerrado mato-grossense para o tratamento de hiperlipidemias e obesidade. Entrevistas com 180 pessoas acima de 50 anos foram realizadas em Nova Xavantina-MT. O questionário abordou nome popular, parte utilizada, forma de preparo e uso das espécies citadas, além de informações gerais sobre o uso de plantas. -Hil.). A folha foi a parte mais utilizada (46%) e o preparo das plantas ocorre principalmente por meio de infusão citado por 36,5% dos entrevistados. Apesar do uso popular destas plantas no combate as hiperlipidemias e obesidade, há necessidade de estudos fitoquímicos e farmacológicos que comprovem estas atividades, com vistas ao desenvolvimento de um fitoterápico.Unitermos: Levantamento etnobotânico, Nova Xavantina, plantas medicinais, anti-hiperlipidêmicas, anorexígenas, Cerrado.ABSTRACT: "Ethnobotanical survey of plants used as anti-hyperlipidemic and anorexigenic by the population of Nova Xavantina-MT, Brazil". This study checked the use of medicinal plants found in the Cerrado mato-grossense for the treatment of hyperlipidemia and obesity. Interviews with 180 people over 50 years were held in Nova Xavantina-MT. The questionnaire addressed popular name, part used, type of preparation and use of the species mentioned, beyond general information about the use of plants. The ten plants most cited were collected, identified and studied through a literature review. Most respondents (95.6%) said using medicinal plants regularly, while 71.5% of them inherited the knowledge of plants of parents and grandparents and 94.20% reported the use to advise youngsters. Furthermore, 93.6% attested that the plants are more effective than the drugs from pharmacy and 57% considered the strong effect of the same, i.e., they always solved health problems. Regarding adverse effects, 95.9% said they have never felt them after the use of plants. Of the respondents, 56.7% knew or had used medicinal plants in the treatment of hyperlipidemias and obesity, being cited 54 medicinal species belonging to 53 different genera and 38 families, with emphasis on Fabaceae (13%

show abstract

Section: Resultsunclassified

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Silva¹,

Melo²,

Ribeiro³

et al. 2010

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…Regarding the safety of herbal medicine, information is contradictory. Therefore, In different countries, to make the use of herbal medicines safer and legislation for these products has undergone changes in recent years, and pharmaceutical companies are instructed to submit data on the efficacy and safety of herbal medicines [11]. Previously, according to Hodge and Sterner toxicity scale, the obtained value of the lethal dose (LD) 50>10,000 mg/kg classified the somina as practically non-toxic herbal medicine [12].…”

Section: Introductionmentioning

confidence: 99%

Effects of Unani Anxiolytics (Somina) on General Reproductive Performance and Teratology in Rats

Ahmed

Azmat

2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: Somina (herbal medicine) is used in Pakistan as Unani anxiolytics. It is composed of five medicinal plants. The current work was designed to evaluate the general reproductive and teratogenic effects of somina in two consecutive generations of rats according to the OECD guideline.Methods: Fertility study (a two-phase study) was done in Sprague-Dawley rats. 1st part: three groups' female rats (10 rats each group) received different doses orally. First group: The control group (saline), a single oral human dose of somina (2 nd group: 285 mg/kg/day) and the high dose of somina (3 rd group: 1g/kg/day) during the whole period of gestation till the delivery of pups named as F1 Breed. For the second part of study ten females were selected from each F1 breed (control, somina 285 mg/kg/d, somina 1g/kg/day) and administered the same treatment from day first of mating than the entire period of gestation until F1 breed delivered pups (F2 breed). For F1 and F2 breed the fertility index and litter size were determined. Some of the female rats (F1 and F2) were anesthetized and autopsied. The blood sample was subjected to biochemical analysis and serum liver function test: bilirubin, gamma-glutamyl transferase (γGT), alanine aminotransferase (ALT: SGPT), aspartate aminotransferase (AST: SGOT) and alkaline phosphatase (ALP) were measured spectrophotometrically. The uterine growth index, fertility index, and litter size were also measured to evaluate the teratogenic effects of somina treated rats. Results:The data showed that any significant different (P>0.05) was not found during the maternal examination (uterine growth index, fertility index) and reproductive parameters (litter size, the quantity of fetus, aborted or absorbed fetus) in somina treated rats as compare to control rats (P>0.05). Control and treated Pups did not show any significant (P>0.05) malformation and any congenital defects. Non-significant (P>0.05) changes were observed in liver function test. It was found normal in all groups. Macroscopic autopsy examination also did not reveal any significant (P>0.05) pathological findings in the liver, kidneys, and uterus. Conclusion:The oral administration of somina during the gestational period of pregnant female rats was not teratogenic/fetotoxic. Any adverse or deleterious effects were not observed at the dose of 285 mg/kg (human dose) or 1g/kg (3times greater than the human dose) during pregnancy, and it is safe in rats.

show abstract

“…Pois o uso popular, acrescido do pensamento de que por ser natural não faz mal, resultou na pequena quantidade de estudos pré-clí-nicos e clínicos com o intuito de comprovar a segurança desses produtos (11).…”

Section: Introductionunclassified

Legislação E Controle De Qualidade De Medicamentos Fitoterápicos Nos Países Do Mercosul

Cechinel-Zanchett

2016

Infarma

View full text Add to dashboard Cite

This study aimed to collect data on herbal medicines in the Mercosul countries, mainly about the major marketed plants, as well as, biological systems with higher prevalence, health control, market data and key aspects related to legislation. The survey was conducted by document analysis, with a literature review on all types of production in Portuguese, English and Spanish (books, dissertations, theses, documents, laws, articles). It was noted that Brazil has a larger number of regulations on the health and quality control of herbal medicines and it is the largest country in the Mercosul. Herbal medicines most commercialized in the country have action on the central nervous (n=6) and respiratory systems (n=6), with 32%, and with 26% (n=5), the gastrointestinal system. Most of them 63% (n=12) is formulated with dry extract. In Argentina and Paraguay, most of them have action on the gastrointestinal system, with 38% (n=16) and 50% (n=7), respectively. It highlights the lack of studies and legislation mainly in Paraguay, Uruguay and Venezuela. Quality control is governed by regulatory issues; however, Uruguay classifies these products as medicines in general, and in Venezuela, as natural products. The lack of specific resolutions, with the exception of Brazil and Argentina, to guide the steps of production and control of herbal medicines, may complicate to discovery process of new bioactive agents from herbal medicines.Keywords: medicinal plants, quality control, herbal medicines, drug regulation, Mercosul. RESUMOO objetivo desse trabalho foi levantar dados sobre medicamentos fitoterápicos nos países do Mercosul, tais como principais plantas comercializadas e sistemas biológicos com maior prevalência, controle sanitário, dados de mercado e principais aspectos relacionados às legislações. A pesquisa foi realizada por meio de análise documental, sendo uma revisão de literatura em todos os tipos de produção em português, inglês e espanhol (livros, dissertações, teses, documentos, legislações, artigos). O Brasil, maior país do Mercosul. apresentou a maior quantidade de regulamentações sobre o controle sanitário e de qualidade de medicamentos fitoterápicose Os medicamentos fitoterápicos mais comercializados no país têm ação no sistema nervoso central (n=6) e sistema respiratório (n=6), com 32%, e no sistema gastrointestinal, com 26% (n=5), e a maioria, 63% (n=12), é formulada com extrato seco. Na Argentina e no Paraguai, a maior parte tem ação no sistema gastrointestinal, com 38% (n=16) e 50% (n=7), respectivamente. É destacada a escassez de estudos e legislações principalmente no Paraguai, Uruguai e Venezuela. E foi possível concluir que o controle da qualidade é regido por órgãos regulamentadores, porém, no Uruguai, medicamentos fitoterápicos são enquadrados como medicamentos em geral, e na Venezuela, como produtos naturais. A falta de resoluções específicas, com exceção do Brasil e Argentina, para nortear as etapas de produção e controle de medicamentos fitoterápicos, dificulta o processo de descobertas de n...

show abstract

Informações toxicológicas de alguns fitoterápicos utilizados no Brasil

Cited by 83 publications

References 6 publications

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Effects of Unani Anxiolytics (Somina) on General Reproductive Performance and Teratology in Rats

Legislação E Controle De Qualidade De Medicamentos Fitoterápicos Nos Países Do Mercosul

Contact Info

Product

Resources

About