Influenza A(H6N1) Virus in Dogs, Taiwan

Lin, Hui-Ting; Wang, Ching-Ho; Chueh, Ling-Ling; Su, Bi-Ling; Wang, Lih-Chiann

doi:10.3201/eid2112.141229

Cited by 48 publications

(42 citation statements)

References 13 publications

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“…For example, in southern and eastern China, H6N6 AIVs were isolated from swine with clinical signs, 11, 12 and in Taiwan, an H6N1 virus was isolated from a dog. 13 Recent seroprevalence research showed seropositivity for H6 viruses among occupational exposure workers in 19 provinces of China, 14 and veterinarians exposed to birds showed H6-specific antibody was significantly elevated in United States. 15 In May 2013, an H6N1 virus was isolated in Taiwan from a 20-year-old woman with symptoms including fever, cough, headache and muscle ache.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of H6 subtype influenza viruses in southern China from 2009 to 2011

Zou

Gao

Zhang

et al. 2016

Emerging Microbes & Infections

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H6 avian influenza viruses (AIVs), which are prevalent in domestic and wild birds in Eurasian countries, have been isolated from pigs, a dog and a human. Routine virological surveillance at live poultry markets or poultry farms was conducted in southern China from 2009 to 2011. This study investigated the genetic and antigenic characteristics, analyzed the receptor-binding properties and evaluated the kinetics of infectivity of the AIVs in A549, MDCK and PK15 cells. A total of 14 H6N6 and 2 H6N2 isolates were obtained from four provinces in southern China. Genetic analysis indicated two distinct hemagglutinin lineages of the H6 strains cocirculating in southern China, and these strains facilitated active evolution and reassortment among multiple influenza virus subtypes from different avian species in nature. None of these isolates grouped with the novel Taiwan H6N1 virus responsible for human infection. Receptor-binding specificity assays showed that five H6 AIVs may have acquired the ability to recognize human receptors. Growth kinetics experiments showed that EV/HB-JZ/02/10(H6N2) and EV/JX/15/10(H6N6) initially reproduced faster and achieved higher titers than other viruses, suggesting that enhanced binding to α-2,6-linked sialic acids correlated with increased viral replication in mammalian cells. Overall, the results emphasize the need for continued surveillance of H6 outbreaks and extensive characterization of H6 isolates to better understand genetic changes and their implications.

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Section: Introductionmentioning

confidence: 99%

Molecular characterization of H6 subtype influenza viruses in southern China from 2009 to 2011

Zou

Gao

Zhang

et al. 2016

Emerging Microbes & Infections

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“…Although outbreaks of Influenza A virus in dogs and horse populations worldwide have been reported, canine (CIV) and equine influenza virus (EIV) had not been detected in Mexico until now. However, the presence of the virus in pets had already been reported in other parts of the world increasing its incidence in domestic animals (Payungporn et al, 2008;Song et al, 2008;Lee et al, 2010;Lin et al, 2015). In this study, 58 nasal fluid, 5 lung necropsies and 5 conjunctival swabs samples from pet dogs with acute respiratory symptoms were used to detect Influenza A virus through matrix gene amplification with the WHO recommended primers.…”

Section: Discussionmentioning

confidence: 98%

Peer Review #2 of "Genetic and serologic surveillance of canine (CIV) and equine (EIV) influenza virus in Nuevo León State, México (v0.1)"

2019

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Background: Despite the uncontrolled distribution of the Influenza A virus through wild birds, the detection of canine (CIV) and equine influenza virus (EIV) in Mexico was absent until now. Recently, outbreaks of equine and canine influenza have been reported around the world; the virus spreads quickly among animals and there is potential for zoonotic transmission. Methods: Amplification of the Influenza A virus matrix gene from necropsies, nasal and conjunctival swabs from trash service horses and pets/stray dogs was performed through RT-PCR. The seroprevalence was carried out through Sandwich ELISA system using the M1 recombinant protein and polyclonal antibodies anti-M1. Results: The matrix gene was amplified from 13 (19.11%) nasal swabs, 2 (2.94%) conjunctival swabs and 5 (7.35%) lung necropsies, giving a total of 20 (29.41%) positive samples in a pet dog population. A total of 6 (75%) positive samples of equine nasal swab were amplified. Sequence analysis showed 96-99% identity with sequences of Influenza A virus matrix gene present in H1N1, H1N2 and H3N2 subtypes. The phylogenetic analysis of the sequences revealed higher identity with matrix gene sequences detected from zoonotic isolates of subtype H1N1/2009.

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“…Sustained canine influenza virus (CIV) infections are more often observed where there are dense populations of dogs, such as animal shelters, races, and dog farming (Voorhees et al, 2018). In the last five years, there have been several reports of canine species infected with IAVs of at least six different subtypes (H1N1, H3N2, H3N8, H5N1, H6N1, H9N2) (Jang et al, 2017;Sun et al, 2013;Songserm et al, 2006;Lin et al, 2015). In recent years, more serious influenza infections in dogs with AIVs have been observed, some of which have caused sustained IAV transmission of virus among dogs (Giese et al, 2008;Song et al, 2008).…”

Section: Canine Influenzamentioning

confidence: 99%

Animal influenza virus infections in humans: A commentary

Borkenhagen

Salman

et al. 2019

International Journal of Infectious Diseases

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Here we review evidence for influenza A viruses (IAVs) moving from swine, avian, feline, equine, and canine species to infect humans. We review case reports, sero-epidemiological, archeo-epidemiological, environmental, and historical studies and consider trends in livestock farming. Although this focused review is not systematic, the aggregated data point to industrialized swine farming as the most likely source of future pandemic viruses, yet IAV surveillance on such farms is remarkably sparse. We recommend increased biosafety and biosecurity training for farm administrators and swine workers with One Health-oriented virus surveillance throughout industrialized farming and meat production lines. Collaborative partnerships with human medical researchers could aid in efforts to mitigate emerging virus threats by offering new surveillance and diagnostic technologies to livestock farming industries.

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Influenza A(H6N1) Virus in Dogs, Taiwan

Cited by 48 publications

References 13 publications

Molecular characterization of H6 subtype influenza viruses in southern China from 2009 to 2011

Molecular characterization of H6 subtype influenza viruses in southern China from 2009 to 2011

Peer Review #2 of "Genetic and serologic surveillance of canine (CIV) and equine (EIV) influenza virus in Nuevo León State, México (v0.1)"

Animal influenza virus infections in humans: A commentary

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