2002
DOI: 10.1590/s0102-09352002000500004
| View full text |Cite
|
Sign up to set email alerts
|

Abstract: Foram investigadas a morfologia e a função tireoidiana de ratas Wistar, adultas, castradas e não castradas e mantidas em estado hipotireóideo pela administração diária de propiltiouracil por 120 dias. Ratas eutireóideas castradas e não castradas serviram de controle. As tireóides, colhidas ao final do experimento, foram pesadas, processadas histologicamente e submetidas à análise morfométrica, pela qual foi determinada a proporção dos componentes glandulares (epitélio folicular, colóide e estroma). No plasma s… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
5
0

Year Published

2003
2003
2016
2016

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 6 publications
(5 citation statements)
references
References 13 publications
0
5
0
Order By: Relevance
“…Animals of the hypothyroid group consumed a mean of 2.20mg of PTU/animal/day and those from the hyperthyroid group ingested a mean of 20.49 g of Lthyroxin/animal/day (Table 2). In rats, 1mg of PTU/kg is the recommended dose to induce hypothyroidism (Serakides et al, 2002;Silva et al, 2004). In a pilot experiment, out this dose yielded no significantly changes in the morphology of the gland and may be enough to induce hypothyroidism in mice in a short term.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Animals of the hypothyroid group consumed a mean of 2.20mg of PTU/animal/day and those from the hyperthyroid group ingested a mean of 20.49 g of Lthyroxin/animal/day (Table 2). In rats, 1mg of PTU/kg is the recommended dose to induce hypothyroidism (Serakides et al, 2002;Silva et al, 2004). In a pilot experiment, out this dose yielded no significantly changes in the morphology of the gland and may be enough to induce hypothyroidism in mice in a short term.…”
Section: Resultsmentioning
confidence: 99%
“…Experimental studies associated with thyroid dysfunctions and changes in the metabolism and body development are based on the suppression of hormone production (McCardle et al, 1998;Ferreira et al, 2003;Khotimchenko e Sergushchenko, 2003;Silva et al, 2004) or thyroxin administration in high doses promoting an iatrogenic hyperthyroidism status (Kobayashi et al, 2000;Serakides et al, 2002;2005). However, most studies recommend the use of traumatic methods and protocols, as for hormone dosage or the induction methodology using rats as animal model.…”
Section: Introductionmentioning
confidence: 99%
“…The hypothyroid rat model (Serakides et al, 2002;Silva et al, 2004) in this study presented by significant decrease in serum fT4 and fT3 and highly significant increase of TSH level throughout the experimental period (Table 1).…”
Section: Discussionmentioning
confidence: 62%
“…Induction of hypothyroidism by Propylthiouracil (PIU) 5 mg kgG 1 b.wt. oral daily dose for 30 days (Serakides et al, 2002;Silva et al, 2004). The development of hypothyroid is considered zero time.…”
Section: Study Groupsmentioning
confidence: 99%
“…Animals and human studies denote thyroid hormones front a charge in cardiovascular, cowardly, immune, and reproductive system development and function (Krassas, 2000). Hyperthyroidism is condition in which the thyirod gland produces and excretes excessive amounts of the free thyroid hormones, triiodothyronine (T3) and thyroxin (T4) (Seragides, et al, 2002).…”
Section: Introductionmentioning
confidence: 99%