Abstract:Isotretinoin is the most effective anti-acne treatment but to some extent it has side effects. So, the aim of the present study was focused on the combined effect of isotretinoin treatment and hypothyroidism on cerebral monoamines in male albino rats. The animals were divided into four groups; control, hypothyroid, hypothyroid treated with isotretinoin and isotretinoin only treated. Hypothyroidism was induced by using 5 mg kgG 1 propylthiouracil for 30 days. Oral isotretinoin was given in olive oil 1.5 mg kgG … Show more
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