Influences of tolfenamic acid and flunixin meglumine on the disposition kinetics of levofloxacin in sheep

Çorum, Duygu Durna; Çorum, Orhan; Yıldız, Ramazan; Faki, Hatice Eser; İder, Merve; Gül, Çetin; Üney, Kamil

doi:10.1556/004.2020.00015

Cited by 8 publications

(7 citation statements)

References 33 publications

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“…Therefore, the high plasma concentration of CFQ in combination with ketoprofen may be a reason for low V darea /F calculation. Similar results have been reported in previous studies (Altan et al, 2020;Durna Corum et al, 2020;Oh & Han, 2006).…”

Section: Discussionsupporting

confidence: 93%

Effect of ketoprofen co‐administration on pharmacokinetics of cefquinome following repeated administration in goats

Tekeli

Türk

Çorum

et al. 2020

Vet Pharm & Therapeutics

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The pharmacokinetics of cefquinome (2 mg/kg every 24 hr for 5 days) was determined following intramuscular administration alone and co‐administration with ketoprofen (3 mg/kg every 24 hr for 5 days) in goats. Six goats were used for the study. In the study, the crossover pharmacokinetics design with 20‐day washout period was performed in two periods. Plasma concentrations of cefquinome were assayed using high‐performance liquid chromatography by ultraviolet detection. The mean terminal elimination half‐life (t1/2ʎz), area under the concentration–time curve (AUC0–24), peak concentration (Cmax), apparent volume of distribution (Vdarea/F), and total body clearance (CL/F) of cefquinome after the administration alone were 4.85 hr, 11.06 hr*µg/ml, 2.37 µg/mL, 1.23 L/kg, and 0.17 L/h/kg after the first dose, and 5.88 hr, 17.01 hr*µg/mL, 3.04 µg/mL, 0.95 L/kg, and 0.11 L/h/kg after the last dose. Ketoprofen significantly prolonged t1/2ʎz of cefquinome, increased AUC0–24 and Cmax, and decreased Vdarea/F and CL/F. Cefquinome exhibited low accumulation after the administration alone and in combination with ketoprofen. These results indicated that ketoprofen prolonged the elimination of cefquinome in goats. The 24‐hr dosing intervals at 2 mg/kg dose of cefquinome, which co‐administered with ketoprofen, may maintain T> minimum inhibitory concentration (MIC) values above 40% in the treatment of infections caused by susceptible pathogens with the MIC value of ≤0.75 μg/ml in goats with an inflammatory condition.

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Section: Discussionsupporting

confidence: 93%

Effect of ketoprofen co‐administration on pharmacokinetics of cefquinome following repeated administration in goats

Tekeli

Türk

Çorum

et al. 2020

Vet Pharm & Therapeutics

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“…Previous unpublished studies in our laboratory have demonstrated that flunixin meglumine pretreatment diminishes the number of ewes that succumb to endotoxemia within the first 24 hours following IV administration of campylobacter. This drug inhibits cyclooxygenase thereby decreasing prostaglandin synthesis [31,32]. In one report in sheep, flunixin meglumine slowed the elimination and increased plasma concentrations of levofloxacin [31].…”

Section: Plos Onementioning

confidence: 99%

“…This drug inhibits cyclooxygenase thereby decreasing prostaglandin synthesis [31,32]. In one report in sheep, flunixin meglumine slowed the elimination and increased plasma concentrations of levofloxacin [31]. It was speculated that inhibition of prostaglandin synthesis in the kidneys by flunixin meglumine caused reduced renal blood flow and a reduced glomerular filtration rate leading to decreased excretion of the antibiotic via urine [31].…”

Section: Plos Onementioning

confidence: 99%

“…In one report in sheep, flunixin meglumine slowed the elimination and increased plasma concentrations of levofloxacin [31]. It was speculated that inhibition of prostaglandin synthesis in the kidneys by flunixin meglumine caused reduced renal blood flow and a reduced glomerular filtration rate leading to decreased excretion of the antibiotic via urine [31]. One study in goats did demonstrate that when flunixin meglumine was administered concurrently with tulathromycin the pharmacokinetics were altered [33].…”

Section: Plos Onementioning

confidence: 99%

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Pharmacokinetics of tulathromycin in pregnant ewes (Ovis aries) challenged with Campylobacter jejuni

Yaeger

Mochel

et al. 2021

PLoS ONE

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The purpose of this study was to evaluate the pharmacokinetics of tulathromycin in the plasma and maternal and fetal tissues of pregnant ewes when administered within 24 hours of a single, IV Campylobacter jejuni (C. jejuni) challenge. Twelve, pregnant ewes between 72–92 days of gestation were challenged IV with C. jejuni IA3902 and then treated with 1.1 ml/45.36 kg of tulathromycin subcutaneously 18 hours post-challenge. Ewes were bled at predetermined time points and euthanized either at a predetermined time point or following the observation of vaginal bleeding or abortion. Following euthanasia, tissues were collected for bacterial culture, pharmacokinetics and histologic examination. The maximum (geometric) mean tulathromycin plasma concentration was estimated at 0.302 μg/mL, with a peak level observed at around 1.2 hours. The apparent systemic clearance of tulathromycin was estimated at 16.6 L/h (or 0.28 L/kg/h) with an elimination half-life estimated at approximately 22 hours. The mean tissue concentrations were highest in the uterus (2.464 μg/g) and placentome (0.484 μg/g), and were lowest in fetal liver (0.11 μg/g) and fetal lung (0.03 μg/g). Compared to previous reports, results of this study demonstrate that prior IV administration of C. jejuni appeared to substantially alter the pharmacokinetics of tulathromycin, reducing both the peak plasma concentrations and elimination half-life. However, additional controlled trials are required to confirm those observations.

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“…These changes may lead to the development of resistance to antibiotics, the emergence of undesirable effects, and a suboptimal level of drug exposure, leading to failure in the treatment of infection [28,29]. Although there are many studies investigating the effects of NSAIDs on the pharmacokinetics of antibiotics in healthy animals [30][31][32][33][34][35][36], studies conducted in the case of disease are limited [37][38][39]. We hypothesized that the effect of meloxicam on the pharmacokinetics of danofloxacin will change with the systemic inflammatory response caused by respiratory infection in lambs, and that the results obtained will contribute to the rational use of danofloxacin.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Behavior and Pharmacokinetic/Pharmacodynamic Integration of Danofloxacin Following Single or Co-Administration with Meloxicam in Healthy Lambs and Lambs with Respiratory Infections

Ural

Üney

2021

Antibiotics

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The aim of this study was to determine the pharmacokinetics and pharmacodynamics of danofloxacin (DAN; 6 mg/kg) following subcutaneous administration alone or co-administration with meloxicam (MLX; 1 mg/kg) in healthy lambs and lambs with respiratory infections. The study was carried out using a total of four groups: HD (healthy; n = 6) and ID (infected; n = 7) groups who were administered DAN only, and HDM (healthy; n = 6) and IDM (infected; n = 7) groups who were administered DAN and MLX simultaneously. The plasma concentrations of DAN were determined using high-performance liquid chromatography–UV and analyzed by the non-compartmental method. DAN exhibited a similar elimination half-life in all groups, including both the healthy and infected lambs. The total clearance in the HDM, ID and IDM groups and volume of distribution in the HDM and IDM groups were significantly reduced. MLX in the IDM group significantly increased the area under the curve (AUC) and peak concentration (Cmax) of DAN compared to the HD group. The Mannheimia haemolytica, Escherichia coli, and Streptococcus spp. strains were isolated from bronchoalveolar lavage fluid samples of the infected lambs. When co-administration with meloxicam, DAN at a 6 mg/kg dose can provide optimum values of ƒAUC0–24/MIC (>56 h) and ƒCmax/MIC (>8) for susceptible M. haemolytica isolates with an MIC90 value of 0.25 µg/mL and susceptible E. coli isolates with an MIC value of ≤0.125 µg/mL.

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Influences of tolfenamic acid and flunixin meglumine on the disposition kinetics of levofloxacin in sheep

Cited by 8 publications

References 33 publications

Effect of ketoprofen co‐administration on pharmacokinetics of cefquinome following repeated administration in goats

Effect of ketoprofen co‐administration on pharmacokinetics of cefquinome following repeated administration in goats

Pharmacokinetics of tulathromycin in pregnant ewes (Ovis aries) challenged with Campylobacter jejuni

Pharmacokinetic Behavior and Pharmacokinetic/Pharmacodynamic Integration of Danofloxacin Following Single or Co-Administration with Meloxicam in Healthy Lambs and Lambs with Respiratory Infections

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