Influences of Hyriopsis cumingii polysaccharides on mice immunosignaling molecules and T lymphocyte differentiation

Abstract

To discuss the molecular mechanism of immunoenhancing activities of Hyriopsis cumingii polysaccharides (HCPS), influences of HCPS on mice immunosignaling molecules (IL-2, IL-10, IFN-γ, NO, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)) and T lymphocyte differentiation (to CD4 + and CD8+ T cells) were evaluated by cell model in vitro and/or cyclophosphamide-induced immunosuppression animal model in vivo. Results showed that gastric gavage of crude HCPS could promote the production of IL-2, IFN-γ, inducible nitric oxide synthase (iNOS), cGMP, CD4 and CD8 in a dose-dependent manner. While, crude HCPS by gastric gavage exhibited suppressive effects on the production of IL-10 and cAMP in a dose-dependent manner. Crude HCPS and its purified fractions (HCPS-1, HCPS-2 and HCPS-3) could strengthen peritoneal macrophage expressing iNOS in vitro in a dose-dependent manner. HCPS-stimulated immunostrengthening functions was mediated, at least in part, by immunosignaling molecules of IL-2, IL-10, IFN-γ, NO, cAMP and cGMP, and T lymphocyte differentiation (to CD4+ and CD8+ T cells). ARTICLE HISTORY

Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets

“…In the present study, the immune-stimulatory properties of the 320 g/t NCG-Cu diet may be superior to that of the 650 g/t CuSO 4 diet, except for IgG. The level of Cu can affect T and B cells, neutrophils and macrophages as well as impair immune function (Liao et al, 2017;Punyokun, Hongprayoon, Srisapoome, & Sirinarumitr, 2013;Qiao et al, 2017). These results suggest that dietary supplementation with 320 g/t NCG-Cu may induce an immune response in piglets by modulating immunoglobulin levels.…”

Protective Role of a New Polysaccharide Extracted from Lonicera japonica Thunb in Mice with Ulcerative Colitis Induced by Dextran Sulphate Sodium

“…Recent studies reported that some polysaccharides, such as Polygonatum sibiricum polysaccharides [ 17 ], Hyriopsis cumingii polysaccharide [ 18 ], and Ganoderma atrum polysaccharide [ 19 ] have been recommended for potential immunostimulants [ 20 , 21 ]. Lonicera japonica Thunb is a very popular traditional Chinese herbal medicine that can be used to prevent and treat various diseases [ 22 ].…”

Immune potentials of theMucor-fermented Mao-tofu and especially its soluble extracts for the normal mice

“…Th2 cytokines (IL-4 and IL-10) (Dey & Chaudhuri, 2014). Hyriopsis cumingii polysaccharides in dose-dependent manner promote IL-2 and IFN-γ production in vivo (Qiao et al, 2017). Doenjang and Cheonggukjang, two fermented soybean products, can upregulate production ratio of IFN-γ to IL-4 in stimulated splenic T-and B-lymphocytes (Lee et al, 2017).…”