Influences of Hyperbaric Oxygen on Blood Pressure, Heart Rate and Blood Glucose Levels in Patients with Diabetes Mellitus and Hypertension

Al-Waili, Noori S.; Butler, Glenn; Beale, Jorge; Abdullah, Mahdi S.; Finkelstein, Michael; Merrow, Michael; Rivera, Richard; Petrillo, Richard; Carrey, Zev; Lee, Bok Jik; Allen, Michael

doi:10.1016/j.arcmed.2006.05.009

Cited by 57 publications

(55 citation statements)

References 21 publications

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“…Different from the results of previous studies showing that HBO had an effect on glucose metabolism (12)(13)(14)(15), HBA treatment did not influence glucose metabolism in our experiments ( Figure 2A, 2B and not shown). Tissue hypoxia (38,39) and TNFα (40) or MCP-1 (41) induce insulin resistance, and high pressure up-regulates glycolytic genes (31).…”

Section: Discussioncontrasting

confidence: 56%

“…In diabetic patients, HBO is also utilized for therapy of gangrene (10) and retinopathy (11). It has been reported that levels of blood glucose in patients with hypertension and type 2 diabetes were significantly lowered by exposure to HBO (12). In animal experiments, HBO treatment prevented an increase in blood glucose level during growth and changed the muscle type to slow twitch subtype (13)(14)(15).…”

Section: Introductionmentioning

confidence: 87%

“…In previous studies, HBO treatment could decrease blood glucose levels in humans (12) and rat (13,14), but investigations with HBO were not done for hyperlipidemia. In addition, the effects of HBA on diabetes and hyperlipidemia have not been studied, either.…”

Section: Discussionmentioning

confidence: 99%

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Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

et al. 2010

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 87%

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Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

et al. 2010

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“…Antihipoksični efekat HBOT se postiže povećanjem njegove rastvorljivosti u tjelesnim tečnostima, a vjerovatno se postižu i određeni efekti preko kiseonik -vezujućih proteina u različitim tkivima. Osim poboljšanja tkivne oksigenacije, efekti HBOT mogu da uključuju i stimulaciju angiogeneze, aktivaciju fibroblasta sa stvaranjam kolagena (profibrotički efekat), povećanu fagocitoznu aktivnost makrofaga, čime se poboljšava antimikrobna zaštita tkiva, smanjenje edema tkiva, prevenciju lipidne peroksidacije i dr. [5][6][7][8][9].…”

Section: Uvodunclassified

“…HBOT smanjuje ekspresiju ICAM-1 indukovanu hipoksijom i hipoglikemijom, pri čemu važnu ulogu može da ima NO sintaza [6,10].…”

Section: Uvodunclassified

Efekti primjene hiperbarične oksigenoterapije na koncentraciju glukoze, triglicerida i holesterola u serumu oboljelih od tipa 2 dijabetes melitusa

Sladoje

Ristić

Maric

et al. 2012

Biomedicinska istraž.

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Kratak sadržajUvod. Dosadašnja istraživanja ukazuju da hiperbarična oksigenoterapija (HBOT) može da ispoljava povoljne efekte na parametre glikoregulacije i inflamacije. Cilj ovog istraživanja je da se utvrdi da li primjena hiperbarične oksigenoterapije utiče na koncentraciju glukoze, triglicerida i holesterola u serumu oboljelih od tipa 2 dijabetes melitusa (DM tip 2).Metode. U studiju je uključen 41 bolesnik sa DM tip 2. Svi su podvrgnuti HBOT 100% kiseonikom pod povišenim pritiskom u trajanju od sat vremena, po pet dana nedjeljno, tokom dvije nedjelje. Pacijentima su određivane koncentrcije glukoze, holesterola (ukupnog, HDL i LDL) i triglicerida u serumu, natašte, prije prvog tretmana HBOT i nakon desetog tretmana HBOT.Rezultati. Poslije dvije nedjelje primjene HBOT kod bolesnika sa DM tip 2 zabilježeno je smanjenje glikemije (9,7 vs. 8,0 mmol/l; p = 0,022) i koncentracije LDL holesterola (4,99 vs. 4,4 mmol/l; p = 0,013) kao i ukupnog holesterola (6,62 vs. 6,06 mmol/l; p =0,015) u serumu. HBOT nije dovela do značajnih promjena koncentracije HDL holesterola (1,22 vs. 1,38 mmol/l; p = 0,66) i triglicerida (1,76 vs. 1,58 mmol/l, p = 0,089) u serumu.Zaključak. Primjena HBOT smanjuje glikemiju i koncentraciju proaterogenih lipida u serumu što može da ima višestruko korisne dejstvo kod oboljelih od DM tip 2.Ključne riječi: hiperbarična oksigenoterapija, tip 2 diabetes mellitus-a, glikemija, lipidemija UvodHiperbarična oksigenoterapija (HBOT) podrazumjeva primjenu 100% kiseonika pod pritiskom koji je veći od onog u atmosferi.Koristi se kao terapija kod različitih stanja: hronične rane koje teško zarastaju, infekcije (posebno one uzrokovane anaerobnim

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Hyperbaric Oxygen Therapy Improves Glucose Homeostasis in Type 2 Diabetes Patients: A Likely Involvement of the Carotid Bodies

Vera-Cruz

Guerreiro

Ribeiro

et al. 2015

Advances in Experimental Medicine and Biology

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The carotid bodies (CBs) are peripheral chemoreceptors that respond to hypoxia increasing minute ventilation and activating the sympathetic nervous system. Besides its role in ventilation we recently described that CB regulate peripheral insulin sensitivity. Knowing that the CB is functionally blocked by hyperoxia and that hyperbaric oxygen therapy (HBOT) improves fasting blood glucose in diabetes patients, we have investigated the effect of HBOT on glucose tolerance in type 2 diabetes patients. Volunteers with indication for HBOT were recruited at the Subaquatic and Hyperbaric Medicine Center of Portuguese Navy and divided into two groups: type 2 diabetes patients and controls. Groups were submitted to 20 sessions of HBOT. OGTT were done before the first and after the last HBOT session. Sixteen diabetic patients and 16 control individual were included. Fasting glycemia was143.5 ± 12.62 mg/dl in diabetic patients and 92.06 ± 2.99 mg/dl in controls. In diabetic patients glycemia post-OGTT was 280.25 ± 22.29 mg/dl before the first HBOT session. After 20 sessions, fasting and 2 h post-OGTT glycemia decreased significantly. In control group HBOT did not modify fasting glycemia and post-OGTT glycemia. Our results showed that HBOT ameliorates glucose tolerance in diabetic patients and suggest that HBOT could be used as a therapeutic intervention for type 2 diabetes.

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Influences of Hyperbaric Oxygen on Blood Pressure, Heart Rate and Blood Glucose Levels in Patients with Diabetes Mellitus and Hypertension

Cited by 57 publications

References 21 publications

Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

Efekti primjene hiperbarične oksigenoterapije na koncentraciju glukoze, triglicerida i holesterola u serumu oboljelih od tipa 2 dijabetes melitusa

Hyperbaric Oxygen Therapy Improves Glucose Homeostasis in Type 2 Diabetes Patients: A Likely Involvement of the Carotid Bodies

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