Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

Takamatsu, Kiyoshi; Hosaka, Toshio; Yamaguchi, Miwa; Terada, Eri; kisyuku, Yuka; Fukunaga, Keiko; Hirata, Y; Jambaldorj, Bayasgalan; Harada, Nagakatsu; Sakai, Tohru; Nakaya, Yutaka

doi:10.2152/jmi.57.224

Cited by 4 publications

(6 citation statements)

References 42 publications

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“…In our study, we observed a significant decrease in FFA after HBOT in T1DM patients. These results are consistent with data gained by Teshigawara et al [31]. Teshigawara et al showed that FFA concentration was significantly decreased after HBOT, implying that HBOT could have beneficial effects on lipid metabolism.…”

Section: Discussionsupporting

confidence: 92%

Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study

Resanović

Gluvić

Zarić

et al. 2019

International Journal of Endocrinology

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This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients. A group of 19 patients (mean age: 63 ± 2.1) with T1DM and with the peripheral arterial disease were included in this study. Patients were exposed to 10 sessions of HBOT in the duration of 1 h to 100% oxygen inhalation at 2.4 ATA. Blood samples were collected for the plasma C-reactive protein (CRP), plasma free fatty acid (FFA), serum nitrite/nitrate, and serum arginase activity measurements. Expression of iNOS and phosphorylation of p65 subunit of nuclear factor-κB (NFκB-p65), extracellular-regulated kinases 1/2 (ERK1/2), and protein kinase B (Akt) were examined in lymphocyte lysates by Western blot. After exposure to HBOT, plasma CRP and FFA were significantly decreased (p < 0.001). Protein expression of iNOS and serum nitrite/nitrate levels were decreased (p < 0.01), while serum arginase activity was increased (p < 0.05) versus before exposure to HBOT. Increased phosphorylation of NFκB-p65 at Ser536 (p < 0.05) and decreased level of NFκB-p65 protein (p < 0.001) in lymphocytes of T1DM patients were observed after HBOT. Decreased phosphorylation of ERK1/2 (p < 0.05) and Akt (p < 0.05) was detected after HBOT. Our results indicate that exposure to HBO decreased iNOS activity/expression via decreasing phosphorylation of ERK1/2 and Akt followed by decreased activity of NFκB.

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Section: Discussionsupporting

confidence: 92%

Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study

Resanović

Gluvić

Zarić

et al. 2019

International Journal of Endocrinology

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“…It is possible that enhanced sympathetic nerve activity decreases the sensitivity of β 2 -adrenergic receptors, which would promote disorder of lipid metabolism. In contrast, stimulation of parasympathetic activities in inflammatory conditions leads to lipid homeostasis (Straznicky et al, 2008;Teshigawara et al, 2010). We speculate that the OLL2712-mediated inhibition of inflammation and normalization of adrenaline levels result in improved lipid metabolism in KKAy mice.…”

mentioning

confidence: 89%

Identification of a Lactobacillus plantarum strain that ameliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice

Toshimitsu

Mochizuki

Ikegami

et al. 2016

Journal of Dairy Science

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In this study, we identified a strain of lactic acid bacteria (LAB) that induces high levels of IL-10 production by immune cells, and evaluated the ability of the strain to suppress chronic inflammation and ameliorate metabolic disorders in in vitro and in vivo models. Among a collection of LAB strains, Lactobacillus plantarum strain OLL2712 (OLL2712) induced the highest levels of IL-10 production in mouse-derived dendritic cells and peritoneal macrophages. The anti-inflammatory effects of this strain were evaluated using a co-culture system comprising RAW 264.7 and 3T3-L1 cells. We also administered heat-killed OLL2712 to obese and type 2 diabetic KKAy mice for 3 wk to evaluate the in vivo effects of the strain. The OLL2712 significantly decreased the production of proinflammatory cytokines in vitro. Likewise, the administration of OLL2712 significantly suppressed proinflammatory cytokine levels in both the visceral adipose tissue and the serum of KKAy mice, and reduced serum triglyceride concentrations. The strain also alleviated oxidative stress and adrenaline levels in the serum of KKAy mice. On the other hand, Lactobacillus gasseri strain MEP222804 (a moderate IL-10 inducer) did not ameliorate the systemic inflammation and hyperlipidemia in KKAy mice. Our results suggest that treatment with strong IL-10-inducing LAB has the potential to ameliorate metabolic disorders by suppressing chronic inflammation in the host animal.

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“…Istraživanja rađena na animalnim modelima ateroskleroze ukazuju da HBOT može da smanjuje progresiju ateroskleroze, odnosno da dovodi u određenoj mjeri i do njene regresije [12,13,17]. HBOT smanjuje ekspresiju ICAM-1 indukovanu hipoksijom i hipoglikemijom, pri čemu važnu ulogu može da ima NO sintaza [6,10].…”

Section: Uvodunclassified

“…Loša kontrola glikemije jedan je od najvažnijih prediktora nastanka mikroangiopatskih komplikacija dijabetesa, ali je značajan faktor rizika i za nastanak makroangiopatskih komplikacija [12][13][14]17].…”

Section: Diskusijaunclassified

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Efekti primjene hiperbarične oksigenoterapije na koncentraciju glukoze, triglicerida i holesterola u serumu oboljelih od tipa 2 dijabetes melitusa

Sladoje

Ristić

Maric

et al. 2012

Biomedicinska istraž.

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Kratak sadržajUvod. Dosadašnja istraživanja ukazuju da hiperbarična oksigenoterapija (HBOT) može da ispoljava povoljne efekte na parametre glikoregulacije i inflamacije. Cilj ovog istraživanja je da se utvrdi da li primjena hiperbarične oksigenoterapije utiče na koncentraciju glukoze, triglicerida i holesterola u serumu oboljelih od tipa 2 dijabetes melitusa (DM tip 2).Metode. U studiju je uključen 41 bolesnik sa DM tip 2. Svi su podvrgnuti HBOT 100% kiseonikom pod povišenim pritiskom u trajanju od sat vremena, po pet dana nedjeljno, tokom dvije nedjelje. Pacijentima su određivane koncentrcije glukoze, holesterola (ukupnog, HDL i LDL) i triglicerida u serumu, natašte, prije prvog tretmana HBOT i nakon desetog tretmana HBOT.Rezultati. Poslije dvije nedjelje primjene HBOT kod bolesnika sa DM tip 2 zabilježeno je smanjenje glikemije (9,7 vs. 8,0 mmol/l; p = 0,022) i koncentracije LDL holesterola (4,99 vs. 4,4 mmol/l; p = 0,013) kao i ukupnog holesterola (6,62 vs. 6,06 mmol/l; p =0,015) u serumu. HBOT nije dovela do značajnih promjena koncentracije HDL holesterola (1,22 vs. 1,38 mmol/l; p = 0,66) i triglicerida (1,76 vs. 1,58 mmol/l, p = 0,089) u serumu.Zaključak. Primjena HBOT smanjuje glikemiju i koncentraciju proaterogenih lipida u serumu što može da ima višestruko korisne dejstvo kod oboljelih od DM tip 2.Ključne riječi: hiperbarična oksigenoterapija, tip 2 diabetes mellitus-a, glikemija, lipidemija UvodHiperbarična oksigenoterapija (HBOT) podrazumjeva primjenu 100% kiseonika pod pritiskom koji je veći od onog u atmosferi.Koristi se kao terapija kod različitih stanja: hronične rane koje teško zarastaju, infekcije (posebno one uzrokovane anaerobnim

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Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

Cited by 4 publications

References 42 publications

Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study

Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study

Identification of a Lactobacillus plantarum strain that ameliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice

Efekti primjene hiperbarične oksigenoterapije na koncentraciju glukoze, triglicerida i holesterola u serumu oboljelih od tipa 2 dijabetes melitusa

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