SummaryBackgroundObesity is one of the most common modern health problems worldwide. Proinflammatory cells accumulate in the adipose tissue of the obese, and the presence of a low level chronic inflammation in obesity is associated with the emergence of a range of metabolic disorders in cluding cardiovascular disease, insulin resistance, type-2 diabetes, fatty-liver disease, and others. Neutrophils are early parti - cipants in inflammatory processes. After the appropriate stimu lation, these cells release reactive oxygen and nitrogen species, which leads to degranulation and secretion of myeloperoxidase and other enzymes. Myelo per oxidase and its reactive oxidants contribute to tissue damage during inflammatory processes in the human body.MethodsThe study included 175 subjects who were, in com - pliance with the International Diabetes Federation criteria, divided into 3 groups: normal weight subjects (N=106), subjects with abdominal obesity (N=37) and the third group consisted of subjects with the metabolic syndrome (N=32).ResultsBy analyzing the myeloperoxidase enzyme activity (kU/L), and the levels of high-sensitivity C-reactive protein in the blood of all subjects, we detected their significantly higher activity and levels in subjects with the metabolic syndrome, as compared to normal weight subjects (p<0.001).ConclusionsBased on our results, we can conclude that the MPO activity in the serum progressively increases with obesity and the metabolic syndrome, which indicates that this prooxidant enzyme may play a role in the pathophysiological mechanisms of the obesity and the metabolic syndrome related complications.
Paraovarian cysts originate from the mesothelium and are presumed to be remnants of Müllerian or Wolffian ducts. In majority of cases they are found to be 10-80 mm in diameter and do not cause any symptoms. Paraovarian cysts can be found unexpectedly during an operation or on ultrasound examination performed for other reasons. They are most freequently discovered on ultrasound examination. However, due to the proximity of the ovary for which cystic formations are not rare, the diagnosis of these lesions can be a challenge. They are mostly asymptomatic and only large lesions (≤20 cm in diameter) become symptomatic. Although these are mostly benign tumors, in rare cases they can become borderline or true malignancies. Most paraovarian cysts are found in the third and fourth decade of life. Paraovarian cyst complications include: compression of the surrounding structures of the pelvis minor and abdomen, pelvic pain, cyst torsion and rupture. Except for the already mensioned complications available literature has so far failed to show cases of uterine prolapse caused by an increase of intra-abdominal pressure due to the expansive growth of giant paraovarian cystic formation.
Kratak sadržajUvod. Dosadašnja istraživanja ukazuju da hiperbarična oksigenoterapija (HBOT) može da ispoljava povoljne efekte na parametre glikoregulacije i inflamacije. Cilj ovog istraživanja je da se utvrdi da li primjena hiperbarične oksigenoterapije utiče na koncentraciju glukoze, triglicerida i holesterola u serumu oboljelih od tipa 2 dijabetes melitusa (DM tip 2).Metode. U studiju je uključen 41 bolesnik sa DM tip 2. Svi su podvrgnuti HBOT 100% kiseonikom pod povišenim pritiskom u trajanju od sat vremena, po pet dana nedjeljno, tokom dvije nedjelje. Pacijentima su određivane koncentrcije glukoze, holesterola (ukupnog, HDL i LDL) i triglicerida u serumu, natašte, prije prvog tretmana HBOT i nakon desetog tretmana HBOT.Rezultati. Poslije dvije nedjelje primjene HBOT kod bolesnika sa DM tip 2 zabilježeno je smanjenje glikemije (9,7 vs. 8,0 mmol/l; p = 0,022) i koncentracije LDL holesterola (4,99 vs. 4,4 mmol/l; p = 0,013) kao i ukupnog holesterola (6,62 vs. 6,06 mmol/l; p =0,015) u serumu. HBOT nije dovela do značajnih promjena koncentracije HDL holesterola (1,22 vs. 1,38 mmol/l; p = 0,66) i triglicerida (1,76 vs. 1,58 mmol/l, p = 0,089) u serumu.Zaključak. Primjena HBOT smanjuje glikemiju i koncentraciju proaterogenih lipida u serumu što može da ima višestruko korisne dejstvo kod oboljelih od DM tip 2.Ključne riječi: hiperbarična oksigenoterapija, tip 2 diabetes mellitus-a, glikemija, lipidemija UvodHiperbarična oksigenoterapija (HBOT) podrazumjeva primjenu 100% kiseonika pod pritiskom koji je veći od onog u atmosferi.Koristi se kao terapija kod različitih stanja: hronične rane koje teško zarastaju, infekcije (posebno one uzrokovane anaerobnim
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