Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight

Abstract

The influence of a proprietary blend of modified cellulose and cetylated fatty acids (Trisynextrade mark, Imagenetix, Inc., San Diego, CA 92127, USA) on adipocytokine and regional body composition responses to a weight loss program was examined. Twenty-two women (Supplement group (S) (n = 11): age = 36.8 +/- 7.2 years; weight = 87.1 +/- 6.2 kg; % body fat = 43.4 +/- 4.1; Placebo group (P) (n = 11): age = 38.3 +/- 6.8 years; weight = 86.9 +/- 4.7 kg; % body fat = 44.3 +/- 2.0) completed an 8-week placebo-controlled, double-blind study consisting of a caloric restricted diet and cardiovascular exercise. Body composition and serum insulin, leptin, and adiponectin were assessed at pre-, mid-, and post-intervention. From pre- to post-intervention, significant decreases (P < 0.05) were observed for body weight (S: 87.1 +/- 6.2-77.9 +/- 5.1 kg; P: 86.9 +/- 4.7-82.7 +/- 3.8 kg) (P < 0.05 S vs. P), % body fat (S: 43.4 +/- 4.1-36.1 +/- 3.6; P: 44.3 +/- 2.0-40.6 +/- 1.2) (P < 0.05 S vs. P), leptin (S: 28.3 +/- 3.5-16.2 +/- 2.6 ng ml(-1); P: 29.4 +/- 3.2-19.9 +/- 1.1 ng ml(-1)) (P < 0.05 S vs. P), and insulin (S: 7.3 +/- 0.8-5.1 +/- 0.2 mU l(-1); P: 7.7 +/- 0.9-5.1 +/- 0.3 mU l(-1)). Serum adiponectin increased (P < 0.05) (S: 12.2 +/- 2.4-26.3 +/- 3.0 microg ml(-1): 12.6 +/- 2.0-21.8 +/- 3.1 microg ml(-1)) (P < 0.05 for S vs. P). Supplementation with a proprietary blend of modified cellulose and cetylated fatty acids during an 8-week weight loss program exhibited favorable effects on adipocytokines and regional body composition.

Effect of diet on adiponectin levels in blood

“…In 27 (51.9%) studies, evaluation of the intervention effect on adiponectin blood levels was the primary outcome, while in others, determination of adiponectin levels was a secondary outcome 21–23,26–29,31,36,38–40,43,46,47,53–55,60,62,65,68,69,71 . Most studies (90.4%) analyzed only the total adiponectin form, while the measurement of at least one of the adiponectin multimeric forms was performed in five studies 26–28,42,71 .…”

“…The number of participants ranged from 10 31 to 219 70 . Fifteen (28.8%) studies included only females, 20,23,24,26,29,31,32,45,49,51,55,63,65,66,70 and seven (13.5%) included only males 22,28,39,40,53,54,69 . Two studies did not report the gender of participants, 42,57 and other studies ( n = 28) included both female and male participants.…”

“…Two studies did not report the gender of participants, 42,57 and other studies ( n = 28) included both female and male participants. Most studies (76.9%) included only overweight participants 20–24,26–38,43,45–48,50–52,55–59,62–71 …”

“…Thirty‐three (63.5%) studies analyzed the role of diet composition in the modulation of adiponectin levels 29–61 . The details of these clinical trials are summarized in Table 2, grouped according to the type of dietary intervention.…”

Effects of a Walking Intervention Using Mobile Technology and Interactive Voice Response on Serum Adipokines Among Postmenopausal Women at Increased Breast Cancer Risk

“…While many studies have shown that serum leptin concentrations decrease following weight loss [14, 22-36], the relationship between serum adiponectin concentrations and weight loss is less clear, although some studies indicate that adiponectin concentrations increase following weight loss [24-26, 29, 36-42]. Similarly, the effect of exercise on serum adipokines is also unclear.…”