Effect of diet on adiponectin levels in blood

Silva, Flávia Moraes; Almeida, J. C.; Feóli, Ana Maria Pandolfo

doi:10.1111/j.1753-4887.2011.00414.x

Cited by 108 publications

(78 citation statements)

References 76 publications

(529 reference statements)

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“…The modest effect of weight change on plasma total adiponectin observed in this study is also consistent with the literature. A recent review found that consistently, significant increases in plasma adiponectin require substantial weight loss of ~7% [24]. While we observed a trend for a time × weight change interaction, confirming that body weight is an important factor in determining plasma adiponectin concentrations, the effect size was very modest, again likely related to the more modest average weight loss in this study compared to previous longer-term studies.…”

Section: Discussionsupporting

confidence: 65%

“…It has therefore remained unclear whether the effects of their dietary intervention may be due to hidden time effects. A recent review therefore concluded that data on the effect of macronutrient composition on plasma adiponectin concentrations are largely inconclusive [24]. The data for measures of low-grade systemic inflammation such as CRP are similarly inconclusive, again largely due to the difficulty in disentangling the relative effects of changes in macronutrient composition and energy balance on the concentrations of the plasma biomarkers.…”

Section: Introductionmentioning

confidence: 99%

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A low-fat high-carbohydrate diet reduces plasma total adiponectin concentrations compared to a moderate-fat diet with no impact on biomarkers of systemic inflammation in a randomized controlled feeding study

et al. 2015

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Purpose We compared the effects of a eucaloric moderate-fat diet (18% protein, 36% fat, 46% carbohydrate), a eucaloric low-fat high-carbohydrate diet (18% protein, 18% fat, and 64% carbohydrate), and a low-calorie (33% reduced) low-fat high-carbohydrate diet on biomarkers of systemic inflammation. Methods We randomly assigned 102 participants (age 21–76 y, BMI 19.2–35.5 kg/m2) to the three different diets for six weeks in a parallel design intervention trial. All foods were provided. Ninety-three participants completed all study procedures; 92 were included in the analyses. Endpoints included plasma C-reactive protein (CRP), interleukin-6 (IL-6), soluble tumor necrosis factor receptors I & II (sTNFRI&II), and adiponectin. Results In the unadjusted primary analyses, none of the endpoints were differentially affected by the dietary interventions despite the significantly greater reductions in body weight and fat mass in participants consuming the low-calorie low-fat diet compared to the eucaloric diets (p<0.001). When including weight change in the model in secondary analysis, adiponectin tended to be increased with weight loss (time × weight change interaction, p=0.051). Adjusted for weight change, adiponectin was reduced in the groups consuming the low-fat diets relative to the moderate-fat diet (p=0.008). No effect of the intervention diets or weight loss on CRP, IL-6 or sTNFR I & II was seen in these secondary analyses. Conclusions In relatively healthy adults, moderate weight loss had minimal effects on systemic inflammation, and raised plasma adiponectin only modestly. A lower dietary fat and higher carbohydrate content had little impact on measures of systemic inflammation, but reduced adiponectin concentrations compared to a moderate-fat diet. The latter may be of concern given the consistent and strong inverse association of plasma adiponectin with many chronic diseases.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

A low-fat high-carbohydrate diet reduces plasma total adiponectin concentrations compared to a moderate-fat diet with no impact on biomarkers of systemic inflammation in a randomized controlled feeding study

et al. 2015

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“…For adiponectin, most weight loss trials including the SHAPE-2 do not observe significant improvements. Reviews suggest that at least 7.5% to 10% weight loss is needed to induce effects (40,47).…”

Section: Discussionmentioning

confidence: 99%

Effect of Weight Loss with or without Exercise on Inflammatory Markers and Adipokines in Postmenopausal Women: The SHAPE-2 Trial, A Randomized Controlled Trial

Gemert

May

Schuit

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: We investigated the effect of equivalent weight loss, by a hypocaloric diet or mainly exercise, on inflammatory markers and adipokines in overweight postmenopausal women.Methods: Women were randomized to a diet (n ¼ 97), mainly exercise (n ¼ 98), or control group (n ¼ 48). Goal of both interventions was to lose 5 to 6 kg bodyweight by a hypocaloric diet or an exercise program (4 hours/week) combined with a small caloric intake restriction. Outcomes after 16 weeks included serum high-sensitive C-reactive protein (hsCRP), IL6, adiponectin, and leptin.Results: Both intervention groups achieved the target weight loss. Controls remained weight stable. Compared with control, hsCRP decreased with mainly exercise [treatment effect ratio (TER) ¼ 0.64] and borderline statistically significant with diet (TER ¼ 0.77). There was a suggestively larger effect of exercise,

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“…Moreover, increased adiponectin levels were already apparent after 1 week (two to three bouts) of moderately intense aerobic exercise, in some cases up to 260% [99]. Regarding diet modifications, several studies reported that daily intake of fish or omega-3 supplementation increased adiponectin levels by amounts ranging from 14 to 60% [100]. Furthermore, adherence to a Mediterranean dietary pattern showed excellent results in T2DM women [101].…”

Section: Introductionmentioning

confidence: 99%

Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease?

Fisman

Tenenbaum

2014

Cardiovasc Diabetol

201

157

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Adiponectin is the most abundant peptide secreted by adipocytes, being a key component in the interrelationship between adiposity, insulin resistance and inflammation. Central obesity accompanied by insulin resistance is a key factor in the development of metabolic syndrome (MS) and future macrovascular complications. Moreover, the remarkable correlation between coronary artery disease (CAD) and alterations in glucose metabolism has raised the likelihood that atherosclerosis and type 2 diabetes mellitus (T2DM) may share a common biological background. We summarize here the current knowledge about the influence of adiponectin on insulin sensitivity and endothelial function, discussing its forthcoming prospects and potential role as a therapeutic target for MS, T2DM, and cardiovascular disease. Adiponectin is present in the circulation as a dimer, trimer or protein complex of high molecular weight hexamers, >400 kDa. AdipoR1 and AdipoR2 are its major receptors in vivo mediating the metabolic actions. Adiponectin stimulates phosphorylation and AMP (adenosin mono phosphate) kinase activation, exerting direct effects on vascular endothelium, diminishing the inflammatory response to mechanical injury and enhancing endothelium protection in cases of apolipoprotein E deficiency. Hypoadiponectinemia is consistently associated with obesity, MS, atherosclerosis, CAD, T2DM. Lifestyle correction helps to favorably modify plasma adiponectin levels. Low adiponectinemia in obese patients is raised via continued weight loss programs in both diabetic and nondiabetic individuals and is also accompanied by reductions in pro-inflammatory factors. Diet modifications, like intake of fish, omega-3 supplementation, adherence to a Mediterranean dietary pattern and coffee consumption also increase adiponectin levels. Antidiabetic and cardiovascular pharmacological agents, like glitazones, glimepiride, angiotensin converting enzyme inhibitors and angiotensin receptor blockers are also able to improve adiponectin concentration. Fibric acid derivatives, like bezafibrate and fenofibrate, have been reported to enhance adiponectin levels as well. T-cadherin, a membrane-associated adiponectin-binding protein lacking intracellular domain seems to be a main mediator of the antiatherogenic adiponectin actions. The finding of novel pharmacologic agents proficient to improve adiponectin plasma levels should be target of exhaustive research. Interesting future approaches could be the development of adiponectin-targeted drugs chemically designed to induce the activaton of its receptors and/or postreceptor signaling pathways, or the development of specific adiponectin agonists.

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Effect of diet on adiponectin levels in blood

Cited by 108 publications

References 76 publications

A low-fat high-carbohydrate diet reduces plasma total adiponectin concentrations compared to a moderate-fat diet with no impact on biomarkers of systemic inflammation in a randomized controlled feeding study

A low-fat high-carbohydrate diet reduces plasma total adiponectin concentrations compared to a moderate-fat diet with no impact on biomarkers of systemic inflammation in a randomized controlled feeding study

Effect of Weight Loss with or without Exercise on Inflammatory Markers and Adipokines in Postmenopausal Women: The SHAPE-2 Trial, A Randomized Controlled Trial

Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease?

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