Influence of Yanyankang Powder (眼炎康散) on Th1/Th2 in rats with experimental autoimmune uveitis

Tian, Qingmei; Bi, Hongsheng; Cui, Yan; Wu, Jianfeng; Xie, Xin; Guo, Dadong; Qian, Ji-cun

doi:10.1007/s11655-015-2182-6

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…The differentiation and ratio of subsets in CD4+ T cells have also been investigated when drugs are administered. A Chinese commercial medicine named Yanyankang powder inhibited the differentiation of Th0 to Th1 cells but promoted Th0 to Th2 cells in autoimmune uveitis rats through downregulation of Th1-secreted IFN-γ but upregulation of Th2 secreted IL-10, which finally reduced the ratio of Th1/Th2 [ 95 – 96 ] . Herbal Scolopendra subspinipes mutilans L. Koch has been used for cancer treatment for hundreds of years in China, and its immunostimulatory activity has been shown to accelerate the Th1/Th2 ratio and increase the number of CD4 + T cells [ 97 ] .…”

Section: Herbal Medicines Regulate the Immune System And May Contribu...mentioning

confidence: 99%

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Regulation of Innate and Adaptive Immunity using Herbal Medicine: Benefits for the COVID-19 Vaccination

Wichai

Wang

et al. 2022

Acupuncture and Herbal Medicine

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Vaccination is a major achievement that has become an effective prevention strategy against infectious diseases and active control of emerging pathogens worldwide. In response to the coronavirus disease 2019 (COVID-19) pandemic, several diverse vaccines against severe acute respiratory syndrome coronavirus 2 have been developed and deployed for use in a large number of individuals, and have been reported to protect against symptomatic COVID-19 cases and deaths. However, the application of vaccines has a series of limitations, including protective failure for variants of concern, unavailability of individuals due to immune deficiency, and the disappearance of immune protection for increasing infections in vaccinated individuals. These aspects raise the question of how to modulate the immune system that contributes to the COVID-19 vaccine protective effects. Herbal medicines are widely used for their immune regulatory abilities in clinics. More attractively, herbal medicines have been well accepted for their positive role in the COVID-19 prevention and suppression through regulation of the immune system. This review presents a brief overview of the strategy of COVID-19 vaccination and the response of the immune system to vaccines, the regulatory effects and mechanisms of herbal medicine in immune-related macrophages, natural killer cells, dendritic cells, and lymphocytes T and B cells, and how they help vaccines work. Later in the article, the potential role and application of herbal medicines in the most recent COVID-19 vaccination are discussed. This article provides new insights into herbal medicines as promising alternative supplements that may benefit from COVID-19 vaccination.

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Section: Herbal Medicines Regulate the Immune System And May Contribu...mentioning

confidence: 99%

“…The Chinese herbal medicinal ingredients have been found to enhance immune response through promotion of T lymphocyte proliferation of and up-regulation of IFN-γ and IL-10 mRNA expressions rabbit hemorrhagic disease vaccine [96] epimedium, propolis, ginseng Lentinus edodes A polysacchari-depeptide complex…”

Section: Resveratrolmentioning

confidence: 99%

Regulation of Innate and Adaptive Immunity using Herbal Medicine: Benefits for the COVID-19 Vaccination

Wichai

Wang

et al. 2022

Acupuncture and Herbal Medicine

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“…Uveitis is an ocular disease that is frequently encountered in clinics and leads to blindness as a result of damage to the uveal canal (iris, corpus ciliare, choroid) (Tian et al, 2015). It is characterized by ocular inflammation that can be formed in acute, recurrent, or persistent phases resulting from deterioration of the blood-ocular barrier and leukocyte infiltration (Yagci et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rat

Erkal

Kılıç

Hatıpoğlu

et al. 2018

IJAR

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Clinical effects and pathological changes of synthetic oligodeoxynucleotide (ODN), prednol (PRD) and azathioprine (AZA) was compared on uveitis treatment in rats. A total of 28 Wistar Albino, female, adult rats were divided into Control (C), PRD, AZA and ODN groups. Uveitis was induced by 176 μg/rat subcutan injection E. coli, LPS and observed in all animals after 48 hours. Then, 0.25 mg/rat/day AZA and 1.25 mg/rat/day of methylprenidolone was administered by gavage in AZA and PRD groups for ten days. In the ODN group, 178 μg/rat ODN was administered IP totally four times. A numerical weight loss was seen in all groups in the course of the infection period, but dropped dramatically in the PRD group during the treatment period. Average value of right and left eye results showed that immunesuppressive effect of Prednol was higher in terms of IOP values compared to others whereas Shirmer test values were the lowest in the post-treatment period. Finally, Prednol was more effective with its immunesuppressive effect resulting in recovery of photophobia, vascularization and oedema in iris vessels.

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T cells in ocular autoimmune uveitis: Pathways and therapeutic approaches

Zhang

2023

International Immunopharmacology

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Influence of Yanyankang Powder (眼炎康散) on Th1/Th2 in rats with experimental autoimmune uveitis

Abstract: Yanyankang powder showed favorable effects in the rats with EAU by influencing the function of Th1 and Th2 cells.

Cited by 4 publications

References 10 publications

Regulation of Innate and Adaptive Immunity using Herbal Medicine: Benefits for the COVID-19 Vaccination

Regulation of Innate and Adaptive Immunity using Herbal Medicine: Benefits for the COVID-19 Vaccination

Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rat

T cells in ocular autoimmune uveitis: Pathways and therapeutic approaches

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