T cells in ocular autoimmune uveitis: Pathways and therapeutic approaches

Zhang, Mi; Zhang, Xiaomin

doi:10.1016/j.intimp.2022.109565

Cited by 11 publications

(3 citation statements)

References 256 publications

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“…One of the currently recognized pathogenic mechanisms of uveitis is the crossing of the blood-retinal barrier by autoreactive CD4+ T cells, activation of local myeloid cells, recruitment of leukocytes including macrophages and monocytes, triggering tissue damage and angiogenesis, and disruption of immune regulation of intraocular tissues ( 31 ). The present study validates the idea from a genetic perspective that CD3 on CM CD4+ T cell and CD3 on CD45RA- CD4+T cell is associated with an increased risk of uveitis.…”

Section: Discussionmentioning

confidence: 99%

Causal role of immune cells in uveitis: Mendelian randomization study

Wu,

Fang,

Zhou

et al. 2024

Front. Immunol.

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BackgroundUveitis, characterized by inflammation of the iris, ciliary body, and choroid, presents a significant global clinical challenge, contributing substantially to visual impairment. Risk factors include autoimmune diseases and immune cell dysfunctions, yet many remain unidentified. Immune cells, notably T cells, B cells, and monocytes, play pivotal roles in uveitis pathogenesis. While biologic agents show promise, comprehensive studies on immune cell types in ocular diseases are lacking. Genome-wide association studies (GWAS) and Mendelian randomization (MR) present promising avenues to elucidate genetic susceptibilities and causal relationships between immune cell traits and uveitis risk.MethodsTwo-sample MR analysis was used to evaluate the causal relationship between 731 immune cells and uveitis, and genome-wide significance analysis was performed for genetic variation in 731 immune cells traits (P < 5 × 10-8). Immune characteristics include median fluorescence intensity (MFI), relative cell counts (RC), absolute cell counts (AC), and morphological parameters (MP), which were determined by published GWAS, and public data from the IEU Open GWAS database. The main analysis method of MR is inverse variance weighting (IVW). Heterogeneity and horizontal pleiotropy were also assessed.Results5 immunophenotypes, including CD62L-DC %DC, IgD+ CD38dim %B cell, CD3 on CM CD4+T cell, CD3 on CD45RA-CD4 +T cell, and CD3 on CD39+ CD4+ Treg may increase the risk of uveitis. 5 immunophenotypes, including CD11b on CD33dim HLA DR-Myeloid cell, HLA DR on CD33dim HLA DR+ CD11b-myeloid cell, CD14-CD16 + %monocyte, HLA DR on CD14-CD16 + monocyte and PDL-1 on CD14-CD16 + monocyte was negatively associated with the risk of uveitis. Among them, HLA DR on CD14-CD16 + monocyte (OR=0.921, 95%CI =0.875-0.970, P=0.001) and HLA DR on CD33dim HLA DR+ CD11b- (OR=0.879, 95%CI = 0.833-0.927, P=0.00) were negatively associated with the risk of uveitis in bi-direction.ConclusionThese results indicate that 10 immune cells traits are significantly associated with the risk of developing uveitis and 2 of them were strongly associated with uveitis bi-directionally, after excluding the effects of confounding factors such as some immune diseases, which provided new ideas and therapeutic targets for the study of immune mechanism of uveitis.

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Section: Discussionmentioning

confidence: 99%

Causal role of immune cells in uveitis: Mendelian randomization study

Wu,

Fang,

Zhou

et al. 2024

Front. Immunol.

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“…Autoimmune retinopathy is a disorder resulting from the loss of photoreceptor function following the development of antibodies against retinal proteins [104]. Autoimmune uveitis involves inflammation of the inner eye (between the sclera and the retina) resulting from the development of antibodies against several ocular antigens [105]. Cogan's syndrome is an autoimmune disorder affecting vision and hearing, resulting from the development of antibodies against corneal and inner ear antigens [106].…”

Section: Autoimmune Visual Disordersmentioning

confidence: 99%

Coenzyme Q10 and Autoimmune Disorders: An Overview

Mantle,

Hargreaves

2024

IJMS

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Some 90 autoimmune disorders have been described in medical literature, affecting most of the tissues within the body. Autoimmune disorders may be difficult to treat, and there is a need to develop novel therapeutic strategies for these disorders. Autoimmune disorders are characterised by mitochondrial dysfunction, oxidative stress, and inflammation; there is therefore a rationale for a role for coenzyme Q10 in the management of these disorders, on the basis of its key role in normal mitochondrial function, as an antioxidant, and as an anti-inflammatory agent. In this article, we have therefore reviewed the potential role of CoQ10, in terms of both deficiency and/or supplementation, in a range of autoimmune disorders.

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“…The abnormal structure of uveitis and uveitis antigen components such as S antigen, P antigen, and IRBP can induce the uveitis sensitization reaction ( 159 ). Immune active substances with HLA to T helper cells will stimulate T cell to activate, leading to differentiation into Th2, Th1, Th17, and Treg cells ( 75 , 160 – 162 ). Th2 cells as control factors of Th1 cells, secretion of IL - 4 and anti-inflammatory factors such as IL - 10, and suppress Th1 tissue damage caused by hyperactivity ( 161 , 163 ).…”

Section: The Application Strategies Of Immunopeptides In Ocular Diseasesmentioning

confidence: 99%

Immunopeptides: immunomodulatory strategies and prospects for ocular immunity applications

Tang,

Qu,

Ning

et al. 2024

Front. Immunol.

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Immunopeptides have low toxicity, low immunogenicity and targeting, and broad application prospects in drug delivery and assembly, which are diverse in application strategies and drug combinations. Immunopeptides are particularly important for regulating ocular immune homeostasis, as the eye is an immune-privileged organ. Immunopeptides have advantages in adaptive immunity and innate immunity, treating eye immune-related diseases by regulating T cells, B cells, immune checkpoints, and cytokines. This article summarizes the application strategies of immunopeptides in innate immunity and adaptive immunity, including autoimmunity, infection, vaccine strategies, and tumors. Furthermore, it focuses on the mechanisms of immunopeptides in mediating ocular immunity (autoimmune diseases, inflammatory storms, and tumors). Moreover, it reviews immunopeptides’ application strategies and the therapeutic potential of immunopeptides in the eye. We expect the immune peptide to get attention in treating eye diseases and to provide a direction for eye disease immune peptide research.

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T cells in ocular autoimmune uveitis: Pathways and therapeutic approaches

Cited by 11 publications

References 256 publications

Causal role of immune cells in uveitis: Mendelian randomization study

Causal role of immune cells in uveitis: Mendelian randomization study

Coenzyme Q10 and Autoimmune Disorders: An Overview

Immunopeptides: immunomodulatory strategies and prospects for ocular immunity applications

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