Abstract:ObjectiveTo evaluate the influence of the type of prosthesis in-hospital mortality in the
post-operative period in patients who had valve replacement.MethodsA cross-sectional data, such as gender, origin, age, etiology, echocardiograph
data, the type of surgery performed and the prosthesis used in cases of valve
replacement were analyzed retrospectively.ResultsWe reviewed 353 charts of patients who underwent valve replacement surgery. The
mean age was 41.87±17.9 years. Regarding gender, 52.8% were female. As f… Show more
“…[7][8][9] In addition, it is known that its prevalence is higher in the female population, 7 which has been confirmed by most studies on valve disease. 8,[11][12][13][14][15][16] As observed in the present study, mean age of patients undergoing valve replacement due to rheumatic etiology is relatively low, in accordance with previous studies. 12,15,17 On the other hand, participants of studies carried out in high-income countries are older, due to the predominance of degenerative and ischemic etiology of valve disease.…”
Section: Discussionsupporting
confidence: 93%
“…Among these, while some studies 10,30 have suggested the use of bioprosthesis as a risk factor, several others have not observed worse outcomes with its use, as we have seen in the present study. 13,18,24,32 It is noteworthy that biological valves have been more frequently used than mechanical ones. The latter require anticoagulation for life, with strict control of INR, and consequently require access to health services and good treatment adherence.…”
Cardiovascular disease (CVD) is the leading cause of death in developed countries 1 and, in Brazil, despite regional differences, CVD kills more than any other cause. 2 CVD is also the leading cause of death among women, and usually occurs 7-10 years later than men. 1 However, the prevalence of this disease increases in the postmenopausal period, possibly due to the decrease in estrogen hormone levels.There are few data in the literature about the assessment of risk factors and treatment of CVDs in women, as compared to men, including in Brazil. This leads to a delay in the institution of appropriate therapies, so that women often receive less aggressive treatments and are less likely than their male counterparts to be managed following recommended guidelines. 3 Mitral valve disease is the most common valvular heart disease. In developing countries, the main cause of mitral valve stenosis is rheumatic fever, and mitral valve replacement is currently one of the most common
“…[7][8][9] In addition, it is known that its prevalence is higher in the female population, 7 which has been confirmed by most studies on valve disease. 8,[11][12][13][14][15][16] As observed in the present study, mean age of patients undergoing valve replacement due to rheumatic etiology is relatively low, in accordance with previous studies. 12,15,17 On the other hand, participants of studies carried out in high-income countries are older, due to the predominance of degenerative and ischemic etiology of valve disease.…”
Section: Discussionsupporting
confidence: 93%
“…Among these, while some studies 10,30 have suggested the use of bioprosthesis as a risk factor, several others have not observed worse outcomes with its use, as we have seen in the present study. 13,18,24,32 It is noteworthy that biological valves have been more frequently used than mechanical ones. The latter require anticoagulation for life, with strict control of INR, and consequently require access to health services and good treatment adherence.…”
Cardiovascular disease (CVD) is the leading cause of death in developed countries 1 and, in Brazil, despite regional differences, CVD kills more than any other cause. 2 CVD is also the leading cause of death among women, and usually occurs 7-10 years later than men. 1 However, the prevalence of this disease increases in the postmenopausal period, possibly due to the decrease in estrogen hormone levels.There are few data in the literature about the assessment of risk factors and treatment of CVDs in women, as compared to men, including in Brazil. This leads to a delay in the institution of appropriate therapies, so that women often receive less aggressive treatments and are less likely than their male counterparts to be managed following recommended guidelines. 3 Mitral valve disease is the most common valvular heart disease. In developing countries, the main cause of mitral valve stenosis is rheumatic fever, and mitral valve replacement is currently one of the most common
“…Demographic results demonstrated a high prevalence of several comorbidities, and procedure details showed a high occurrence of other valve interventions and surgeries associated with coronary artery bypass grafting. In addition, there is a known high prevalence of rheumatic valve disease, which is a major cause of heart disease in developing countries [ 13 ] . It was observed low late mortality (> 30 days after implant) similar to those described in the literature for other types of actual market bioprosthesis [ 14 , 15 , 16 ] .…”
Objective
To assess actual data on the safety, effectiveness, and hemodynamic
performance of Bovine Pericardium Organic Valvular Bioprosthesis (BVP).
Methods
The BIOPRO Trial is an observational, retrospective, non-comparative,
non-randomized, and multicenter study. We collected data from 903 patients
with symptomatic, moderate, or severe valve disease who underwent BVP
implants in the timeframe from 2013 to 2020 at three Brazilian institutions.
Death, valve-related adverse events (AEs), functional recovery, and
hemodynamic performance were evaluated at the hospital, at discharge, and
six months and one year later. Primary analysis compared late (> 30 days
after implant) linearized rates of valve-related AEs, such as
thromboembolism, valve thrombosis, major hemorrhage, major paravalvular
leak, and endocarditis, following objective performance criteria (OPC).
Analysis was performed to include at least 400 valve-years for each valve
position (aortic and mitral) for complete comparisons to OPC. Kaplan-Meier
survival and major adverse cardiovascular and cerebrovascular event analyses
were also performed.
Results
This retrospective study analyzed follow-up data collected from 903 patients
(834.2 late patient-years) who have undergone surgery for 455 isolated
aortic valve replacement (50.4%), 382 isolated mitral valve replacement
(42.3%), and 66 combined valve replacement or other intervention (7.3%). The
linearized rates of valve-related AEs were < 2 × OPC. One-year
survival rates were 95.1% and 92.7% for aortic and mitral valve replacement,
respectively. This study demonstrated an improvement in the New York Heart
Association classification from baseline and hemodynamic performance within
an expected range.
Conclusion
According to this analysis, BVP meets world standards for safety and clinical
efficacy.
Objetivo: Verificar a existência de evidências científicas na literatura sobre o conhecimento dos pacientes em relação ao uso do anticoagulante oral após o implante de valva cardíaca metálica. Método: Revisão integrativa realizada nas bases de dados Embase, Scopus, Web of Science e Sistema Online de Busca e Análise de Literatura Médica (MEDLINE)/PubMed, utilizando descritores controlados e não controlados, sem delimitação temporal quanto à publicação, nos idiomas português, inglês e espanhol. A busca ocorreu em junho de 2022, por duas pesquisadoras de forma independente. Resultado: Verificou-se a existência de lacunas no conhecimento dos pacientes sobre os efeitos adversos relacionados ao uso dos anticoagulantes orais, às interações medicamentosas, às interações alimentares, aos fatores que interferem nos níveis do international normalized ratio e ao que deve ser feito em caso de esquecimento das doses diárias. Conclusão: A síntese elaborada enfatiza a necessidade de maior enfoque nas orientações aos pacientes sobre os anticoagulantes e suas implicações relacionadas aos hábitos de vida diária.
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