Influence of ultra-fine grain structure on corrosion behaviour of biodegradable Mg-1Ca alloy

Парфенов, Е.В.; Kulyasova, Olya B.; Mukaeva, V. R.; Mingo, B.; Фаррахов, Р. Г.; Cherneikina, Ya.V.; Yerokhin, Aleksey; Zheng, Yufeng; Valiev, Ruslan Z.

doi:10.1016/j.corsci.2019.108303

Cited by 71 publications

(23 citation statements)

References 56 publications

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“…The intrinsic difference between Mg–Si–Ca alloy and the other two implants is the presence of the second phase. In this study, Mg 2 Ca in Mg–Si–Ca alloy is recognized as an anode in the Mg–Mg2Ca galvanic couple, [ 27 , 28 ] while MgCaSi acts as a cathode in the Mg–MgCaSi couple. [ 29 ] Therefore, the Mg 2 Ca phase is supposed to degrade before the Mg matrix, followed by the degradation of the MgCaSiphase (Equations ( 1 )–( 4 )) [ 30 ]

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Section: Discussionmentioning

confidence: 99%

Biomimicking Bone–Implant Interface Facilitates the Bioadaption of a New Degradable Magnesium Alloy to the Bone Tissue Microenvironment

Qiao

Liu

et al. 2021

Advanced Science

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The most critical factor determining the success of biodegradable bone implants is the host tissue response, which greatly depends on their degradation behaviors. Here, a new magnesium-based implant, namely magnesium-silicon-calcium (Mg-0.2Si-1.0Ca) alloy, that coordinates its biodegradation along with the bone regenerative process via a self-assembled, multilayered bone-implant interface is designed. At first, its rapid biocorrosion contributes to a burst release of Mg 2+ , leading to a pro-osteogenic immune microenvironment in bone. Meanwhile, with the simultaneous intervention of Ca and Si in the secondary phases of the new alloy, a hierarchical layered calcified matrix is rapidly formed at the degrading interface that favored the subsequent bone mineralization. In contrast, pure Mg or Mg-0.2Si alloy without the development of this interface at the beginning will unavoidably induce detrimental bone loss. Hence, it is believed this biomimicking interface justifies its bioadaptability in which it can modulate its degradation in vivo and accelerate bone mineralization.

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…”

Section: Discussionmentioning

confidence: 99%

Biomimicking Bone–Implant Interface Facilitates the Bioadaption of a New Degradable Magnesium Alloy to the Bone Tissue Microenvironment

Qiao

Liu

et al. 2021

Advanced Science

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“…In addition to a positive effect on the strength characteristics of magnesium alloys, as noted above, SPD often does not impair their corrosion resistance [15,16,17]. Thus, it was shown for a Mg-1Ca alloy that the formation of a UFG structure after high pressure torsion (HPT) leads to a significant increase in the corrosion resistance of the alloy in Ringer’s solution [31]. The authors argued that the mechanism of increased corrosion resistance is based on a balance between the processes of anodic dissolution of the Ca-containing secondary phase and deposition of hydroxide compounds on the specimen surface, which inhibits corrosion.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties, Biodegradation, and Biocompatibility of Ultrafine Grained Magnesium Alloy WE43

et al. 2019

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In this work, the effect of an ultrafine-grained (UFG) structure obtained by multiaxial deformation (MAD) on the mechanical properties, fatigue strength, biodegradation, and biocompatibility in vivo of the magnesium alloy WE43 was studied. The grain refinement down to 0.93 ± 0.29 µm and the formation of Mg41Nd5 phase particles with an average size of 0.34 ± 0.21 µm were shown to raise the ultimate tensile strength to 300 MPa. Besides, MAD improved the ductility of the alloy, boosting the total elongation from 9% to 17.2%. An additional positive effect of MAD was an increase in the fatigue strength of the alloy from 90 to 165 MPa. The formation of the UFG structure also reduced the biodegradation rate of the alloy under both in vitro and in vivo conditions. The relative mass loss after six weeks of experiment was 83% and 19% in vitro and 46% and 7% in vivo for the initial and the deformed alloy, respectively. Accumulation of hydrogen and the formation of necrotic masses were observed after implantation of alloy specimens in both conditions. Despite these detrimental phenomena, the desired replacement of the implant and the surrounding cavity with new connective tissue was observed in the areas of implantation.

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“…where ∆m is the mass loss in grams, t is the immersion time in hours, A is the specimen surface area in cm 2 , and ρ is the density of the alloy in g/cm 3 . The surface of the samples after degradation tests was inspected using an instrumental microscope MMI-2 (NPZ, Novosibirsk, USSR).…”

Section: Methodsmentioning

confidence: 99%

“…The combination of good biocompatibility and acceptable mechanical properties made magnesium alloys one of the most popular groups of materials for bioresorbable implants [1][2][3][4][5][6][7]. In recent years, research has been increasingly directed towards the development of magnesium alloys for medical applications.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Equal-Channel Angular Pressing on Microstructure, Mechanical Properties, and Biodegradation Behavior of Magnesium Alloyed with Silver and Gadolinium

et al. 2020

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The effect of equal channel angular pressing (ECAP) on the microstructure, texture, mechanical properties, and corrosion resistance of the alloys Mg-6.0%Ag and Mg-10.0%Gd was studied. It was shown that ECAP leads to grain refinement of the alloys down to the average grain size of 2–3 μm and 1–2 μm, respectively. In addition, in both alloys the precipitation of fine particles of phases Mg54Ag17 and Mg5Gd with sizes of ~500–600 and ~400–500 nm and a volume fraction of ~9% and ~8.6%, respectively, was observed. In the case of the alloy Mg-6.0%Ag, despite a significant grain refinement, a drop in the strength characteristics and a nearly twofold increase in ductility (up to ~30%) was found. This behavior is associated with the formation of a sharp inclined basal texture. For alloy Mg-10.0%Gd, both ductility and strength were enhanced, which can be associated with the combined effect of significant grain refinement and an increased probability of prismatic and basal glide. ECAP was also shown to cause a substantial rise of the biodegradation rate of both alloys and an increase in pitting corrosion. The latter effect is attributed to an increase in the dislocation density induced by ECAP and the occurrence of micro-galvanic corrosion at the matrix/particle interfaces.

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Influence of ultra-fine grain structure on corrosion behaviour of biodegradable Mg-1Ca alloy

Cited by 71 publications

References 56 publications

Biomimicking Bone–Implant Interface Facilitates the Bioadaption of a New Degradable Magnesium Alloy to the Bone Tissue Microenvironment

Biomimicking Bone–Implant Interface Facilitates the Bioadaption of a New Degradable Magnesium Alloy to the Bone Tissue Microenvironment

Mechanical Properties, Biodegradation, and Biocompatibility of Ultrafine Grained Magnesium Alloy WE43

The Effect of Equal-Channel Angular Pressing on Microstructure, Mechanical Properties, and Biodegradation Behavior of Magnesium Alloyed with Silver and Gadolinium

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