Influence of TT virus on the histopathological features of nonalcoholic fatty liver disease

TT virus: virological and genomic characteristics and disease associations

“…87 In liver biopsy specimens, moderate to large numbers of acidophilic bodies, moderate-to -marked focal/spotty necrosis of hepatocytes, and marked stellate, pericellular, or perivenular fibrosis were observed significantly more frequently among those who were positive for TTV DNA by N22 PCR than among those who were negative for TTV DNA by N22 PCR. These results suggest that TTV infection detectable by N22 PCR influences the necrosis and inflammation of hepatocytes and liver fibrosis in patients with nonalcoholic fatty liver disease.…”

Clinical characteristics and prevalence of GB virus C, SEN virus, and HFE gene mutation in Japanese patients with nonalcoholic steatohepatitis

“…16,39 Additionally, a recent study suggested that certain TTV genotypes, including genotype 1, influence necrosis and the inflammation of hepatocytes and liver fibrosis in NAFLD patients. 19 We therefore examined whether infection by GBV-C and the newly discovered human virus, SENV, had any influence on the histological features of NAFLD. We found that the frequencies of GBV-C infection and SENV-D/-H infection did not differ significantly between the two groups.…”

“…17 Although subsequent studies have demonstrated a high prevalence of TTV among healthy individuals, and a lack of association with transfusion-associated hepatitis, 18 there is a possibility that certain TTV genotypes, including genotype 1, influence the development of necrosis, inflammation, and fibrosis of the liver in NAFLD patients. 19 Recently, a novel DNA virus, distantly related to the TTV, was detected in the serum of an intravenous drug abuser also infected with human immunodeficiency virus, and was designated the SEN virus (SENV). 20,21 Eight different strains have been isolated; SENV-A to -H. Genotypes SENV-D and SENV-H were more prevalent in the serum samples of patients with transfusion-associated non-A to -E hepatitis and showed a lower prevalence in serum samples from healthy blood donors.…”

High TT virus load as an independent factor associated with the occurrence of hepatocellular carcinoma among patients with hepatitis C virus‐related chronic liver disease

“…Zein et al [1999] reported that TTV infection was more prevalent among patients with advanced HCV-associated liver disease (decompensated cirrhosis and HCC) than in those with stable disease (chronic hepatitis and compensated cirrhosis). It was suggested recently that infection of certain TTV genotypes may interfere with the improvement of liver function following the start of abstinence, in patients with alcoholic liver disease [ Tokita et al, 2001a], and influence the necrosis and inflammation of hepatocytes and liver fibrosis in patients with nonalcoholic fatty liver disease [Tokita et al, 2001b]. Furthermore, Moriyama et al [2001] reported that the score of irregular regeneration of hepatocytes in TTV-infected cirrhotic patients with chronic hepatitis C was higher than that in the nonviremic patients, suggesting that TTV infection may influence the development of HCV-related HCC.…”