Clinical characteristics and prevalence of GB virus C, SEN virus, and HFE gene mutation in Japanese patients with nonalcoholic steatohepatitis

Yamauchi, Norihito; Itoh, Yoshito; Tanaka, Yasuhito; Mizokami, Masashi; Minami, Masahito; Morita, Atsuhiro; Toyama, Tetsuya; Yamaguchi, Kanji; Fujii, Hideki; Okanoue, Takeshi

doi:10.1007/s00535-003-1361-y

Cited by 29 publications

(19 citation statements)

References 40 publications

(80 reference statements)

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“…Hepatic iron overload thought to be associated with HFE gene mutations [10,11]. A significantly higher prevalence of HFE mutations in NASH patients has been reported as a factor responsible for liver fibrosis by increasing hepatic iron deposition [14,32], but recent studies have failed to confirm this [33][34][35]. In our study the prevalence of hyperferritinemia was significantly higher in the NASH patients than in patients with simple steatosis.…”

Section: Discussioncontrasting

confidence: 66%

Serum Ferritin Is a Clinical Biomarker in Japanese Patients with Nonalcoholic Steatohepatitis (NASH) Independent of HFE Gene Mutation

et al. 2009

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury. The spectrum of NAFLD is broad, extending from simple steatosis through nonalcoholic steatohepatitis (NASH). Iron is regarded as a putative element that interacts with oxygen radicals, and high rates of hyperferritinemia and increased hepatic iron stores have been demonstrated in NASH. We investigated serum ferritin concentrations, HFE gene mutations, and insulin resistance in Japanese NASH patients and the diagnostic utility of serum ferritin concentrations as a means of distinguishing NASH. Serum ferritin concentrations were measured in 86 patients with histopathologically verified NAFLD (24 with steatosis and 62 with NASH) and 20 control subjects, they were tested for HFE gene mutations and their insulin resistance was measured. The serum ferritin concentration was significantly higher in the NASH patients than in the patients with simple steatosis (P = 0.006). There was no significant difference between the groups in HFE gene mutation (C282Y, H63D, and S65C), and the serum ferritin level was related with insulin resistance. The area under the ROC curve was 0.732 for distinguishing NASH from simple steatosis (P = 0.005; 95% CI, 0.596-0.856). In conclusion high serum ferritin concentrations are a distinguishing feature of Japanese NASH patients independent of HFE gene mutations.

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Section: Discussioncontrasting

confidence: 66%

Serum Ferritin Is a Clinical Biomarker in Japanese Patients with Nonalcoholic Steatohepatitis (NASH) Independent of HFE Gene Mutation

et al. 2009

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“…Many previous studies conducted in predominantly Caucasian populations suggested that HFE mutations are more common among patients with NASH or NAFLD, compared to control populations, implicating HFE as a susceptibility locus for this disease [3,8,[71][72][73][74]. Not surprisingly, HFE mutations were infrequent among NASH cohorts in the non-Caucasian populations of Brazil [75], Japan [76,77], Taiwan [78] and India [79,80]. However, a recent study suggests that H63D HFE mutations may be more prevalent among Koreans with NAFLD than control subjects [81].…”

Section: The Role Of Mutations In Hfe and Other Hepcidin Regulatory Gmentioning

confidence: 89%

Iron Metabolism in Nonalcoholic Fatty Liver Disease

Nelson

Klintworth

Kowdley

2011

Curr Gastroenterol Rep

106

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Non-Alcoholic Fatty Liver Disease (NAFLD) is a common worldwide clinical and major public health problem affecting both adults and children in developed nations. Increased hepatic iron stores are observed in about one-third of adult NAFLD patients. Iron deposition may occur in parenchymal and/or non-parenchymal cells of the reticuloendothelial system (RES). Similar patterns of iron deposition have been associated with increased severity of other chronic liver diseases including HCV infection and dysmetabolic iron overload, suggesting there may be a common mechanism for hepatic iron deposition in these diseases. In NAFLD, iron may potentiate the onset and progression of disease by increasing oxidative stress and altering insulin signaling and lipid metabolism. The impact of iron in these processes may depend upon the sub-cellular location of iron deposition in hepatocytes or RES cells. Iron depletion therapy has shown efficacy at reducing serum aminotransferase levels and improving insulin sensitivity in subjects with NAFLD.

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“…Similarly, none of the patients with NAFLD/NASH in Japan was found to have HFE gene mutations. 95 In a multiethnic study from Australia, only Anglo-Celtic patients were found to have increased C282Y heterozygosity in NASH compared with controls, although it did not predict for disease severity or fibrosis. None were homozygous for the mutation.…”

Section: Patatin-like Phospholipase Domain-containing Protein 3 and Nmentioning

confidence: 97%

Non-alcoholic Fatty Liver Disease: East Versus West

Agrawal

Duseja

2012

Journal of Clinical and Experimental Hepatology

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Non-alcoholic fatty liver disease (NAFLD) is an important cause of liver disease worldwide with prevalence ranging from 10% to 30% in various countries. It has become an important cause of unexplained rise in transaminases, cryptogenic cirrhosis, and cryptogenic hepatocellular carcinoma. Pathogenesis is related to obesity, insulin resistance, oxidative stress, lipotoxicity, and resultant inflammation in the liver progressing to fibrosis. Pharmacological treatment in patients with NAFLD is still evolving and the treatment of these patients rests upon lifestyle modification with diet and exercise being the cornerstones of therapy. While there are many similarities between patients with NAFLD from Asia and the West, there are certain features which make the patients with NAFLD from Asia stand apart. This review highlights the data on NAFLD from Asia comparing it with the data from the West. ( J CLIN EXP HEPATOL 2012;2:122-134)

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Clinical characteristics and prevalence of GB virus C, SEN virus, and HFE gene mutation in Japanese patients with nonalcoholic steatohepatitis

Abstract: Higher serum AST and ferritin, and lower serum T-Chol are distinctive features in NASH when compared with simple steatosis. GBV-C infection, SENV infection, and HFE gene mutation were not considered to influence the development of NASH from simple fatty liver.

Cited by 29 publications

References 40 publications

Serum Ferritin Is a Clinical Biomarker in Japanese Patients with Nonalcoholic Steatohepatitis (NASH) Independent of HFE Gene Mutation

Serum Ferritin Is a Clinical Biomarker in Japanese Patients with Nonalcoholic Steatohepatitis (NASH) Independent of HFE Gene Mutation

Iron Metabolism in Nonalcoholic Fatty Liver Disease

Non-alcoholic Fatty Liver Disease: East Versus West

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