Influence of Treatment with Extracts of &lt;i&gt;Hypsyzigus marmoreus&lt;/i&gt; Mushroom on Body Composition during Obesity Development in KK-A&lt;sup&gt;y&lt;/sup&gt; Mice

Iuchi, Takujiro; Hosaka, Toshio; Shiroishi, Masahiro; Ono, Hiraku; Inukai, Kouichi; Sumita, Takashi; Sakai, Gouta; Katayama, Shigehiro; Awata, Takuya

doi:10.3177/jnsv.61.96

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…The following additional selected studies provide a starting point for further reading on the antiobesity properties of mushroom polysaccharides and mushrooms: Mizutani, et al [ 128 ]; Handayani, et al [ 129 ]; Inoue, et al [ 130 ]; Kanagasabapathy, et al [ 131 ]; Vincent, et al [ 132 ]; Handayani, et al [ 133 ]; Park, et al [ 134 ]; Zheng, et al [ 135 ]; Iuchi, et al [ 136 ]; Mori, et al [ 137 ]; and Reza, et al [ 138 ].…”

Section: Antiobesity Effectsmentioning

confidence: 99%

Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans

Friedman

2016

Foods

266

150

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More than 2000 species of edible and/or medicinal mushrooms have been identified to date, many of which are widely consumed, stimulating much research on their health-promoting properties. These properties are associated with bioactive compounds produced by the mushrooms, including polysaccharides. Although β-glucans (homopolysaccharides) are believed to be the major bioactive polysaccharides of mushrooms, other types of mushroom polysaccharides (heteropolysaccharides) also possess biological properties. Here we survey the chemistry of such health-promoting polysaccharides and their reported antiobesity and antidiabetic properties as well as selected anticarcinogenic, antimicrobial, and antiviral effects that demonstrate their multiple health-promoting potential. The associated antioxidative, anti-inflammatory, and immunomodulating activities in fat cells, rodents, and humans are also discussed. The mechanisms of action involve the gut microbiota, meaning the polysaccharides act as prebiotics in the digestive system. Also covered here are the nutritional, functional food, clinical, and epidemiological studies designed to assess the health-promoting properties of polysaccharides, individually and as blended mixtures, against obesity, diabetes, cancer, and infectious diseases, and suggestions for further research. The collated information and suggested research needs might guide further studies needed for a better understanding of the health-promoting properties of mushroom polysaccharides and enhance their use to help prevent and treat human chronic diseases.

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Section: Antiobesity Effectsmentioning

confidence: 99%

Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans

Friedman

2016

Foods

266

150

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“…The production volume of Japanese mushrooms was recently estimated at about 440,000 tons per year, with Flammulina velutipes (Enokitake) produced in the largest quantities, followed by Hypsizygus marmoreus (Bunashimeji), Lentinus edodes (Shiitake), Grifola frondosa (Maitake) and Pleurotus eryngii (Eringi or King oyster mushroom) [ 5 ]. These mushrooms contain many nutritional components such as dietary fiber, vitamin B 1 , vitamin B 2 , niacin, vitamin B 6 , vitamin D and folic acid [ 3 ], and are reported to have anti-obesity effects [ 6 , 7 , 8 , 9 ], immunomodulatory effects [ 10 ], anti-tumor effects [ 11 ], anti-atherosclerotic effects [ 12 ] and anti-diabetes effects [ 13 ]. However, these studies do not take into account the quantity of mushrooms realistically consumed as part of the diet.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Intake of Japanese Mushrooms on Visceral Fat Accumulation and Gut Microbiota in Mice

et al. 2018

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A lot of Japanese people are generally known for having a healthy diet, and consume a variety of mushrooms daily. Many studies have reported anti-obesity effects of mushrooms, but few have investigated the effects of consuming a variety of edible mushroom types together in realistic quantities. In this study, we investigated whether supplementation with a variety of mushroom types affects visceral fat accumulation and gut microbiota in mice. The most popular mushroom varieties in Japan were lyophilized and mixed according to their local production ratios. C57BL/6J mice were fed a normal diet, high-fat (HF) diet, HF with 0.5% mushroom mixture (equivalent to 100 g mushrooms/day in humans) or HF with 3% mushroom mixture (equivalent to 600 g mushrooms/day in humans) for 4 weeks. The mice were then sacrificed, and blood samples, tissue samples and feces were collected. Our results show that mushroom intake suppressed visceral fat accumulation and increased the relative abundance of some short chain fatty acid- and lactic acid-producing gut bacteria. These findings suggest that mushroom intake is an effective strategy for obesity prevention.

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“…Obesity is a major worldwide health problem, and it has been implicated in the development of various diseases, such as diabetes, hyperlipidemia, and atherosclerosis. Extracts of Pleurotus Florida showed promising effects against obesity, their administration to high-cholesterol diet rats inhibits their weight gain, reduces total cholesterol level, LDL as well as triglycerides and also reduces fat deposition within the body of high-fat obese mice (Iuchi et al 2015). β-Glucan found in the extract of Pleurotus sajor-caju inhibits obesity in high-fat diet obese mice (Kanagasabapathy et al 2013).…”

Section: Anti-obesity Activity Of Mushroommentioning

confidence: 99%

Medicinal mushroom: boon for therapeutic applications

et al. 2018

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Medicinal mushrooms are higher fungi with additional nutraceutical attributes having low fat content and a trans-isomer of unsaturated fatty acids along with high fibre content, triterpenes, phenolic compounds, sterols, eritadenine and chitosan. They are considered as the unmatched source of healthy foods and drugs. They have outstanding attractive taste, aroma and nutritional value, so are considered as functional food, which means they are beneficial to the body not only in terms of nutrition but also for improved health. Medicinal mushrooms and their extract have a large number of bioactive components called secondary metabolites. The presence of polysaccharide β-glucans or polysaccharide-protein complexes content in mushroom extract have great therapeutic applications in human health as they possess many properties such as anti-diabetic, anti-cancerous, anti-obesity, immunomodulatory, hypocholesteremia, hepatoprotective nature along with anti-aging. The present review focuses on the comprehensive account of the medicinal properties of various medicinal mushrooms. This will further help the researchers to understand the metabolites and find other metabolites as well from the mushrooms which can be used for the potential development of the drugs to treat various life-threatening diseases.

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Influence of Treatment with Extracts of <i>Hypsyzigus marmoreus</i> Mushroom on Body Composition during Obesity Development in KK-A<sup>y</sup> Mice

Cited by 5 publications

References 19 publications

Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans

Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans

Effects of Dietary Intake of Japanese Mushrooms on Visceral Fat Accumulation and Gut Microbiota in Mice

Medicinal mushroom: boon for therapeutic applications

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