Medicinal mushroom: boon for therapeutic applications

Chaturvedi, Vivek K.; Agarwal, Sonam; Gupta, Krishna Kumar; Ramteke, Pramod W.; Singh, Mohan

doi:10.1007/s13205-018-1358-0

Cited by 140 publications

(96 citation statements)

References 101 publications

(105 reference statements)

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“…These present in mushrooms belong to the 1,3-β-glucan family and have anti-tumor activity that operates by enhancing and blocking cellular immune pathways. [69,70] The content of water-soluble polysaccharides in T. indicum from different regions ranges from 70.23 to 115.24 mg/g dw ( Table 4). Tibetan truffles possess the highest polysaccharide content, followed by truffles from Hebei, Gongshan, Liaoning and Qujing.…”

Section: Polysaccharidesmentioning

confidence: 99%

Chemical Composition and Antioxidant Activity of Tuber indicum from Different Geographical Regions of China

Liang

Qiao

et al. 2019

Chemistry & Biodiversity

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Tuber indicum, an endemic truffle species in eastern Asian, is an edible mushroom that is both an important export and widely distributed across China. Many existing studies on truffles focus on analyzing their taxonomy, population genetics, volatile organic compounds and artificial cultivation of the truffles, while little information is available about their nutrient composition and pharmacological activity, especially the relationship between chemical composition in ascocarps and their geographic distributions. This study presents a comprehensive investigation of the chemical composition of T. indicum, including free sugars, fatty acids, organic acids, phenolic acids, flavonoids, and polysaccharides, and tracks the antioxidant activity of T. indicum ascocarps collected from five geographical regions of four provinces in P. R. China: Hebei, Tibet, Yunnan, and Liaoning province. Our results showed that T. indicum collected from Qujing, Yunnan province, possessed the highest amount of free sugars (23.67 mg/g dw), total flavonoids (2.31 mg/g dw), total phenolics (4.46 mg/g dw) and the highest DPPH and ABTS radical‐scavenging activities. The amount of water‐soluble polysaccharides was the highest (115.24 mg/g dw) in ascocarps from Tibet, the total organic acids was the highest (22.073 mg/g dw) in ascocarps from Gongshan, and polyunsaturated fatty acids were most abundant in those from Hebei province. This study reveals that the quantity of chemical compounds in T. indicum varies by geographical origin. Detecting differences in chemical composition may provide important data for understanding the relationship between environmental factors and truffle formation, as well as quality evaluation of the commercial species T. indicum throughout China.

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Section: Polysaccharidesmentioning

confidence: 99%

Chemical Composition and Antioxidant Activity of Tuber indicum from Different Geographical Regions of China

Liang

Qiao

et al. 2019

Chemistry & Biodiversity

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“…Medicinal mushrooms are rich sources of pharmacologically active compounds (Chaturvedi et al , ). Ganoderma lucidum , a traditional medicinal mushroom, has been used to improve health and longevity in China for several millennia (Hsu and Cheng, ).…”

Section: Introductionmentioning

confidence: 99%

“…Medicinal mushrooms are rich sources of pharmacologically active compounds (Chaturvedi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Dual sgRNA‐directed gene deletion in basidiomycete Ganoderma lucidum using the CRISPR/Cas9 system

Liu

Sun

You

et al. 2020

Microbial Biotechnology

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Ganoderma lucidum is an important medicinal mushroom in traditional Chinese medicine. However, the lack of adequate genetic tools has hindered molecular genetic research in and the genetic modification of this species. Here, we report that the presence of an intron is necessary for the efficient expression of the heterologous phosphinothricin‐resistance and green fluorescent protein genes in G. lucidum. Moreover, we improved the CRISPR/Cas9‐mediated gene disruption frequency in G. lucidum by adding an intron upstream of the Cas9 gene. Our results showed that the disruption frequency of the orotidine 5’‐monophosphate decarboxylase gene (ura3) in transformants containing the glyceraldehyde‐3‐phosphate dehydrogenase gene intron in the Cas9 plasmid is 14–18 in 107 protoplasts, which is 10.6 times higher than that in transformants without any intron sequence. Furthermore, genomic fragment deletions in the ura3 and GL17624 genes were achieved via a dual sgRNA‐directed CRISPR/Cas9 system in G. lucidum. We achieved a ura3 deletion frequency of 36.7% in G. lucidum. The developed method provides a powerful platform to generate gene deletion mutants and will facilitate functional genomic studies in G. lucidum.

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“…Mushrooms are emerging as promising sources for naturally occurring novel bioactive compounds, as many studies have found their bioactive properties, including anti-cancer, anti-diabetic, anti-obesity, and hypocholesterolemic effects [30]. These beneficial effects of mushrooms on human health are attributed to a large number of secondary metabolites in their extracts.…”

Section: Discussionmentioning

confidence: 99%

Vulpinic Acid Controls Stem Cell Fate toward Osteogenesis and Adipogenesis

Nam

Kim

et al. 2019

Genes

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Vulpinic acid, a naturally occurring methyl ester of pulvinic acid, has been reported to exert anti-fungal, anti-cancer, and anti-oxidative effects. However, its metabolic action has not been implicated yet. Here, we show that vulpinic acid derived from a mushroom, Pulveroboletus ravenelii controls the cell fate of mesenchymal stem cells and preadipocytes by inducing the acetylation of histone H3 and α-tubulin, respectively. The treatment of 10T1/2 mesenchymal stem cells with vulpinic acid increased the expression of Wnt6, Wnt10a, and Wnt10b, which led to osteogenesis inhibiting the adipogenic lineage commitment, through the upregulation of H3 acetylation. By contrast, treatment with vulpinic acid promoted the terminal differentiation of 3T3-L1 preadipocytes into mature adipocytes. In this process, the increase in acetylated tubulin was accompanied, while acetylated H3 was not altered. As excessive generation of adipocytes occurs, the accumulation of lipid drops was not concentrated, but dispersed into a number of adipocytes. Consistently, the expressions of lipolytic genes were upregulated and inflammatory factors were downregulated in adipocytes exposed to vulpinic acid during adipogenesis. These findings reveal the multiple actions of vulpinic acid in two stages of differentiation, promoting the osteogenesis of mesenchymal stem cells and decreasing hypertrophic adipocytes, which can provide experimental evidence for the novel metabolic advantages of vulpinic acid.

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Medicinal mushroom: boon for therapeutic applications

Cited by 140 publications

References 101 publications

Chemical Composition and Antioxidant Activity of Tuber indicum from Different Geographical Regions of China

Chemical Composition and Antioxidant Activity of Tuber indicum from Different Geographical Regions of China

Dual sgRNA‐directed gene deletion in basidiomycete Ganoderma lucidum using the CRISPR/Cas9 system

Vulpinic Acid Controls Stem Cell Fate toward Osteogenesis and Adipogenesis

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