Influence of the addition of different radiopacifiers and bioactive nano-hydroxyapatite on physicochemical and biological properties of calcium silicate based endodontic ceramic

Antonijevic, Djordje; Despotović, Ana; Biočanin, Vladimir; Milošević, Miloš; Trišić, Dijana; Lazović, Vladimir; Zogović, Nevena; Milašin, Jelena; Ilic, Dragan

doi:10.1016/j.ceramint.2021.07.052

Cited by 15 publications

(4 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown by the resulting radiopacity and DTS, the MTA-like cement prepared using 1000 °C-calcined powder exhibited optimal performance and was investigated further concerning its biocompatibility with MG63 and L929 cell lines using the CCK8 kit. MG63 cells are similar to human osteoblasts and are considered reliable for testing biocompatibility [ 43 ], whereas L929 cells are more sensitive, and their use is recommended by the ISO standard [ 44 ]. Both MG63 and L929 cells were treated with three different concentrations of extracts (1/10,000, 1/1000, and 1/100) from MTA-like cement.…”

Section: Resultsmentioning

confidence: 99%

Effects of Calcination Temperature on the Synthesis of One-Pot Sol-Gelled Barium Titanate Powder and Its Performance as an Endodontic Radiopacifier

Chang,

Chen,

Cheng

et al. 2024

Materials

View full text Add to dashboard Cite

Barium titanate (BaTiO3, BTO), conventionally used for dielectric and ferroelectric applications, has been assessed for biomedical applications, such as its utilization as a radiopacifier in mineral trioxide aggregates (MTA) for endodontic treatment. In the present study, BTO powders were prepared using the sol-gel process, followed by calcination at 400–1100 °C. The X-ray diffraction technique was then used to examine the as-prepared powders to elucidate the effect of calcination on the phase composition and crystalline size of BTO. Calcined BTO powders were then used as radiopacifiers for MTA. MTA-like cements were investigated to determine the optimal calcination temperature based on the radiopacity and diametral tensile strength (DTS). The experimental results showed that the formation of BTO phase was observed after calcination at temperatures of 600 °C and above. The calcined powders were a mixture of BaTiO3 phase with residual BaCO3 and/or Ba2TiO4 phases. The performance of MTA-like cements with BTO addition increased with increasing calcination temperature up to 1000 °C. The radiopacity, however, decreased after 7 days of simulated oral environmental storage, whereas an increase in DTS was observed. Optimal MTA-like cement was obtained by adding 40 wt.% 1000 °C-calcined BTO powder, with its resulting radiopacity and DTS at 4.83 ± 0.61 mmAl and 2.86 ± 0.33 MPa, respectively. After 7 days, the radiopacity decreased slightly to 4.69 ± 0.51 mmAl, accompanied by an increase in DTS to 3.13 ± 0.70 MPa. The optimal cement was biocompatible and verified using MG 63 and L929 cell lines, which exhibited cell viability higher than 95%.

show abstract

Section: Resultsmentioning

confidence: 99%

Effects of Calcination Temperature on the Synthesis of One-Pot Sol-Gelled Barium Titanate Powder and Its Performance as an Endodontic Radiopacifier

Chang,

Chen,

Cheng

et al. 2024

Materials

View full text Add to dashboard Cite

show abstract

“…Different analyses have shown that MTA powder is approximately a mixture of Portland cement and bismuth oxide. 14 Different studies introduced Portland cement as an applicable alternative to MTA due to its similar biological, antimicrobial, and physicochemical properties. 14 The pure form of Portland cement alone could induce dentinogenesis, but due to the lack of radiopacity, it is not appropriate for clinical application.…”

Section: Palabras Clavementioning

confidence: 99%

“…14 Different studies introduced Portland cement as an applicable alternative to MTA due to its similar biological, antimicrobial, and physicochemical properties. 14 The pure form of Portland cement alone could induce dentinogenesis, but due to the lack of radiopacity, it is not appropriate for clinical application. 15 To overcome this drawback, many suitable radioopacifying agents have been introduced.…”

Section: Palabras Clavementioning

confidence: 99%

Synthesis, characterization, and evaluation of nano-hydroxyapatite based experimental calcium silicate cement as a root repair material

Sharifi¹,

Dizaj²,

Shahi³

et al. 2022

J Oral Res

View full text Add to dashboard Cite

Introduction: This study aimed to prepare a new root repair material including Portland cement, bismuth oxide, and nano-hydroxyapatite and analyze its physicochemical properties and its effects on the proliferation and differentiation of human dental pulp stem cells (hDPSCs). Material and Methods: Bismuth oxide as a radiopaque component and nano-hydroxyapatite particles were added to white Portland cement at 20% and 5% weight ratio, respectively. Characterization of the prepared cement was done using con-ventional methods. To examine the bioactivity of this new material, atomic absorption spectroscopy (AAS) was used for the investigation of the rate of calcium ions dissolution in simulated body fluid media. The viability of hDPSCs was assessed by an MTT assay after 1, 3 and 7 days. The odontogenic potential of this substance was evaluated by measuring alkaline phosphatase activity and alizarin red S staining. Results: Based on the bioactivity results, the cement presented high bio-activity, corroborating sufficiently with the calcium release patterns. The cell viability was significantly increased in new root repair ma-terial containing hydroxyapatite nanoparticles after 3 and 7 days (p<0.05). Conclusion: Moreover, alkaline phosphatase activity increased over 7 days in all experimental groups. The new cement containing nano-hydroxyapatite particles could be a good root repair material.

show abstract

“…High temperature metastable phases such as bismuth oxide-based materials can be prepared by high energy ball milling processes. Bismuth oxide can be used either as an ionic conductor in solid oxide fuel cells [ 12 , 13 , 14 ] or as a radiopacifier within endodontic filling mineral trioxide aggregates (i.e., MTA) [ 15 , 16 , 17 ] and has attracted considerable research and development interest [ 18 , 19 ]. Bismuth oxide possesses four different phases (α-, β-, γ-, and δ) [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Tantalum Pentoxide Addition on the Radiopacity Performance of Bi2O3/Ta2O5 Composite Powders Prepared by Mechanical Milling

Lin

Chang

et al. 2021

Materials

View full text Add to dashboard Cite

Among the various phases of bismuth oxide, the high temperature metastable face-centered cubic δ phase attracts great attention due to its unique properties. It can be used as an ionic conductor or an endodontic radiopacifying material. However, no reports concerning tantalum and bismuth binary oxide prepared by high energy ball milling and serving as a dental radiopacifier can be found. In the present study, Ta2O5-added Bi2O3 composite powders were mechanically milled to investigate the formation of these metastable phases. The as-milled powders were examined by X-ray diffraction and scanning electron microscopy to reveal the structural evolution. The as-milled composite powders then served as the radiopacifier within mineral trioxide aggregates (i.e., MTA). Radiopacity performance, diametral tensile strength, setting times, and biocompatibility of MTA-like cements solidified by deionized water, saline, or 10% calcium chloride solution were investigated. The experimental results showed that subsequent formation of high temperature metastable β-Bi7.8Ta0.2O12.2, δ-Bi2O3, and δ-Bi3TaO7 phases can be observed after mechanical milling of (Bi2O3)95(Ta2O5)5 or (Bi2O3)80(Ta2O5)20 powder mixtures. Compared to its pristine Bi2O3 counterpart with a radiopacity of 4.42 mmAl, long setting times (60 and 120 min for initial and final setting times) and 84% MG-63 cell viability, MTA-like cement prepared from (Bi2O3)95(Ta2O5)5 powder exhibited superior performance with a radiopacity of 5.92 mmAl (the highest in the present work), accelerated setting times (the initial and final setting time can be shortened to 25 and 40 min, respectively), and biocompatibility (94% cell viability).

show abstract

Influence of the addition of different radiopacifiers and bioactive nano-hydroxyapatite on physicochemical and biological properties of calcium silicate based endodontic ceramic

Cited by 15 publications

References 71 publications

Effects of Calcination Temperature on the Synthesis of One-Pot Sol-Gelled Barium Titanate Powder and Its Performance as an Endodontic Radiopacifier

Effects of Calcination Temperature on the Synthesis of One-Pot Sol-Gelled Barium Titanate Powder and Its Performance as an Endodontic Radiopacifier

Synthesis, characterization, and evaluation of nano-hydroxyapatite based experimental calcium silicate cement as a root repair material

Effect of Tantalum Pentoxide Addition on the Radiopacity Performance of Bi2O3/Ta2O5 Composite Powders Prepared by Mechanical Milling

Contact Info

Product

Resources

About